Vaccine diluent and its preparation method

A diluent and vaccine technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low uniformity of immune titers, affecting the immune effect of swine fever vaccine, etc. , to enhance the immune response of the body, improve the activity of NK cells, and ensure the effect of sterility

Inactive Publication Date: 2018-06-12
杭州洪桥中科基因技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Freeze-dried swine fever vaccine needs to be diluted with vaccine diluent before use, usually water for injection or normal saline is used, but the immune titer produced by the vaccine diluted in this way is not high, which will affect the immunity of swine fever vaccine effect, needs to be improved

Method used

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  • Vaccine diluent and its preparation method
  • Vaccine diluent and its preparation method
  • Vaccine diluent and its preparation method

Examples

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Effect test

Embodiment 1

[0044] Embodiment 1: A kind of vaccine diluent, each component and weight parts in the raw material are as shown in Table 1. A kind of preparation method of vaccine diluent comprises the following steps:

[0045] Step 1, mixing physiological saline, aluminum stearate, and ganoderma lucidum polysaccharide and stirring evenly to obtain a spare mixed solution;

[0046] Step 2, using a high-pressure homogenizer to perform nano-processing on the standby mixed solution to obtain a nano-mixed solution;

[0047] In step 3, filter and sterilize the nano-mixture with a 0.2 μm microporous membrane.

Embodiment 2

[0048] Embodiment 2: A vaccine diluent, the difference from Embodiment 1 is that the components and parts by weight in the raw materials are as shown in Table 1.

Embodiment 3

[0049] Embodiment 3: A kind of vaccine diluent, each component and weight parts in the raw material are as shown in Table 1. A kind of preparation method of vaccine diluent comprises the following steps:

[0050] Step 1, mixing physiological saline, aluminum stearate, ganoderma lucidum polysaccharide, and anthocyanins and stirring evenly to obtain a spare mixed solution;

[0051] Step 2, using a high-pressure homogenizer to perform nano-processing on the standby mixed solution to obtain a nano-mixed solution;

[0052] In step 3, filter and sterilize the nano-mixture with a 0.2 μm microporous membrane.

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Abstract

The invention discloses a vaccine diluent and its preparation method. The vaccine diluent is prepared from, by weight, 100-120 parts of normal saline, 0.5-2 parts of aluminum stearate, and 3-6 parts of ganoderan. Aluminum stearate has emulsification effect, and can improve the mixing uniformity of vaccine diluent while promote the mixing uniformity of vaccine diluent after mixing with vaccine, andfurther improve the uniformity of immunizing potency generated after diluting vaccine. The aluminum stearate has slow release effect, and can postpone retention time of immunogen in an organ, thus the immunogen can be continuously and slowly released, the phagocytosis and sterilizing abilities of macrophage are enhanced, and the immunoreaction caused by immunogen is further improved. Ganoderan isa good traditional Chinese medicine active component, and able to improve the phagocytosis function of the macrophage, enhance the cell function of humoral immunity and further improve the vaccine valence; by matching with the slow release effect of aluminum stearate, the vaccine valence by ganoderan is further promoted.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a vaccine diluent and a preparation method thereof. Background technique [0002] Vaccines refer to biological products made from various pathogenic microorganisms for vaccination. The purpose of immunization is to induce the body to produce a strong immune response to the vaccination antigen, so as to protect the body from the invasion of corresponding pathogens. [0003] Classical swine fever is an infectious disease caused by the swine fever virus of the family Flaviviridae, which is highly contagious and lethal, and only infects pigs under natural conditions. The swine fever vaccine is made of attenuated swine fever rabbit vaccine, which can effectively control swine fever. [0004] Freeze-dried swine fever vaccine needs to be diluted with vaccine diluent before use, usually water for injection or normal saline is used, but the immune titer produced by the vaccine diluted in this...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K47/12A61K47/36A61K31/715A61K31/353A61K31/704A61K9/127A61P37/04
CPCA61K9/127A61K31/353A61K31/704A61K31/715A61K39/39A61K47/12A61K47/36A61K2039/55511A61K2039/55555A61K2039/55577A61K2039/55583A61K2300/00
Inventor 汪艳党占国杨芳陈健
Owner 杭州洪桥中科基因技术有限公司
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