Novel solid paste formula and preparation method thereof

A solid and ointment technology, which is applied in the field of new solid ointment and its preparation, can solve the problems that people with three high levels and diabetics should not take it, high requirements for heat control, and precipitation of active ingredients, so as to reduce pesticide residues and heavy metals content, a wide range of applicable people, and the effect of shortening the production time

Inactive Publication Date: 2018-06-15
GUANGDONG AUTHENTEA BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional paste preparation method requires repeated decoction of various decoction pieces at high temperature, which consumes a lot of energy and takes a long production cycle. The control requirements are high, and the active ingredients are prone to precipitate and precipitate during the operation process of concentration and ointment collection, and problems such as burnt blocks are caused by excessive heating; and in the traditional ointment preparation method, the extraction

Method used

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  • Novel solid paste formula and preparation method thereof
  • Novel solid paste formula and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The following formulations were used as raw materials for the preparation of the new solid Bazhen ointment in this example: 2 kg of ginseng, 7 kg of Atractylodes macrocephala, 5.5 kg of white poria cocos, 7 kg of angelica, 3.5 kg of Chuanxiong, 5.5 kg of white peony, 10 kg of rehmannia glutinosa, and 3.5 kg of roasted licorice.

[0028] The preparation method of the novel solid ointment side of the present embodiment comprises the following steps:

[0029] S1. Crush the effective parts of all raw materials to 100 meshes, and fully mix them with purified water at a ratio of 1:20 to obtain a mixed solution.

[0030] S2. Fully break the wall of the mixed solution, filter and remove the slag to obtain the extract; the step of breaking the wall is: the obtained mixed solution is subjected to torrent breaking under the conditions of a low pressure of 20 MPa, a high pressure of 180 MPa, and a temperature of 25 ° C. wall extraction.

[0031] S3. Filter the extract with a micro...

Embodiment 2

[0034] The following formulations were used as raw materials for the preparation of the novel solid Qiongyu paste in this example: 0.75 kg of ginseng, 1.5 kg of white poria cocos, and 8 kg of rehmannia glutinosa.

[0035] The preparation method of the novel solid ointment side of the present embodiment comprises the following steps:

[0036] S1. Crush the effective parts of all raw materials to 120 meshes, and fully mix them with purified water at a ratio of 1:20 to obtain a mixed solution;

[0037] S2. Fully break the wall of the mixed solution, filter and remove the slag to obtain the extract; the step of breaking the wall is: the obtained mixed solution is subjected to torrent breaking under the conditions of a low pressure of 15 MPa, a high pressure of 200 MPa, and a temperature of 20 ° C. wall extraction.

[0038] S3. Filter the extract with a microfiltration membrane to remove suspended particles, bacteria and large molecular weight colloids in the extract, then filter ...

Embodiment 3~8 and comparative example 2~5

[0050] The degree of crushing of raw materials and the condition parameters of wall-breaking extraction (see Table 1) were changed to study their effects on the yield of solid paste and the content of effective active ingredients. Other parameters were the same as in Example 1.

[0051] Table 1

[0052]

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PUM

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Abstract

The invention provides a novel solid paste formula and a preparation method thereof. The preparation method includes the following steps: S1, pulverizing raw materials into 60-200 mesh, and mixing with water according to the mass ratio of 1 to (15-30), to obtain a mixed solution; S2, wall-breaking the mixed solution, and filtering to remove residues, to obtain an extraction solution; S3, filteringand purifying the extraction solution by microfiltration, ultrafiltration and nanofiltration in turn, to obtain a filtrate; and S4, under the conditions of negative pressure and the temperature of 25-30 DEG C, dehydrating the filtrate obtained by the S3, controlling the water content to 3% or less, and thus obtaining the solid paste formula. The preparation method solves the problem of active ingredient deactivation caused by high-temperature repeated decoction of a conventional solid paste formula, has low energy consumption, greatly shortens the production time, and can improve the paste production rate of the solid paste formula. The obtained solid paste formula crystal has the advantages of standard quantization, convenient carrying, taking at any time, good experience feeling and high safety while intactly retaining the comprehensive effect of nourishment tonifying and treatment prevention of a classic paste formula.

Description

technical field [0001] The invention relates to the field of plasters of traditional Chinese medicine, in particular to a novel solid plaster and a preparation method thereof. Background technique [0002] "Ointment" is a traditional Chinese medicine ointment taken for the main purpose of health care, also known as "ointment", which is one of the oldest prescription forms. After concentration, the semi-fluid dosage form made by adding sugar or honey is mainly aimed at the long-term conditioning and nourishing health of chronic wasting diseases. It has the functions of nourishing and strengthening the body, anti-aging and prolonging life, and curing diseases. The function of the ointment includes the dual function of "rescuing side effects and eliminating diseases". Ointment can be used for diseases caused by deficiency, and ointment can be used for chronic, intractable, and consumptive diseases. Therefore, ointment is different from other tonics and invigorating prescriptio...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K36/804A61P39/00A61P1/14
CPCA61K9/0053A61K9/06A61K36/076A61K36/232A61K36/236A61K36/258A61K36/284A61K36/484A61K36/65A61K36/71A61K36/804A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 周粤生卢泽菁梁志朋郑镇钦李腾姬
Owner GUANGDONG AUTHENTEA BIOTECH INC
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