Treatment method for acid dissolution refining mother solution of riboflavin

A treatment method, riboflavin acid technology, applied in the direction of organic chemistry, to achieve the effects of reducing production costs, increasing the speed of filtration, and reducing high-salt wastewater

Active Publication Date: 2018-06-22
HUBEI GUANGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is, the method solves the problem of high-salt wastewater produced by traditional follow-up treatment methods in the process of preparing high-content riboflavin, and improves the extraction yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 500L acid-soluble and refined mother liquor, with an acid content of 6.9%, and 2276ppm of riboflavin. Batch rectify the acid-soluble mother liquor, control the feed rate at 1L / min, first run for 1 hour under the condition of reflux ratio of 0.5, so that the operation of the whole rectification column is stable, and then carry out rectification at this reflux ratio . Tower top obtains the dilute hydrochloric acid that concentration is 19.3%, volume is about 200L, and tower bottom obtains the mixed solution of volume about 300L, contains riboflavin 4006ppm in this solution, and acid content is 0.45%. The solution was left to stand to allow the riboflavin to precipitate. Firstly, the feed liquid is filtered through a tube membrane, the total membrane area is about 3 square meters, the pore size of the membrane is 100-200nm, the operating pressure is 0.15MPa, and the temperature of the feed liquid is controlled below 35°C. Recover the undissolved riboflavin, the permeate ...

Embodiment 2

[0041] 800L acid-soluble and refined mother liquor, with an acid content of 7.4%, and 2900ppm of riboflavin. Batch rectification of the acid-soluble mother liquor, control the feed rate at 1.5L / min, first run for 1 hour at a reflux ratio of 0.7, so that the entire rectification column runs stably, and then carry out rectification at this reflux ratio. distillation. Tower top obtains concentration and is 19.0% dilute hydrochloric acid, volume is about 300L. Tower bottom obtains the mixed solution of volume about 500L, contains riboflavin 4600ppm in this solution, and acid content is 0.4%. The solution was left to stand to allow the riboflavin to precipitate. Firstly, the feed liquid is filtered through a tube membrane, the total membrane area is about 3 square meters, the pore size of the membrane is 100-200nm, the operating pressure is 0.15MPa, and the temperature of the feed liquid is controlled below 35°C. Recover undissolved riboflavin, and the permeate after passing thro...

Embodiment 3

[0043] This embodiment adopts the traditional neutralization method to process the riboflavin in the acid-soluble refining mother liquor and reclaims it, which is a comparative example of embodiment 2.

[0044] 800L acid-soluble and refined mother liquor, with an acid content of 7.4%, and 2900ppm of riboflavin. In order to recover the riboflavin in it and discharge the sewage up to the standard, first neutralize the acid in it with lye, adjust the pH to 6.5, and use about 65kg of alkali to obtain a mixed solution with a salt content of 10% and 2900ppm of riboflavin, and let it stand This mixed solution allows riboflavin to separate out, because riboflavin increases greatly in the solubility of riboflavin in saline solution, filters this solution and obtains about 1kg of riboflavin, obtains high salt content of about 10% in the clear liquid after filtering Salt wastewater, due to the high salt content, the biochemical treatment of the wastewater is difficult, the cycle is long ...

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Abstract

The invention discloses a treatment method for acid dissolution refining mother solution of riboflavin, which belongs to the technical field of riboflavin extraction. The method comprises the following steps: acid dissolution refining mother solution undergoes a process of extracting concentrated hydrochloric acid by batch fractionating, so that azeotropic hydrochloric acid, the aid content of which is about 20 percent, is obtained; because the content of hydrochloric acid in the acid dissolution mother solution is reduced in the process of extracting concentrated hydrochloric acid, from 6 to8 percent to about 0.5 percent, and part of moisture is evaporated out, riboflavin is separated out from the mother solution, and riboflavin therein is then recovered by membrane separation of concentrated crystals and other steps. The step of membrane separation of concentrated crystals includes two stages of membrane treatment, i.e., tubular membrane pretreatment (microfiltration) and diffusiondialysis membrane treatment, the concentrate of a diffusion dialysis membrane returns into a pretreating tubular membrane again, and soluble riboflavin in penetrating liquid pretreated by the tubularmembrane is further recovered. After treatment by the method, the yield of extracted riboflavin in the process of preparing high-content riboflavin is increased by about 3 percent, and the discharge of high-salinity wastewater is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of riboflavin extraction, in particular to a method for treating riboflavin acid-dissolved and refined mother liquor. Background technique [0002] Riboflavin, also known as vitamin B2 (referred to as VB2), is a water-soluble vitamin necessary for the human body. As a basic nutrient, riboflavin has a wide range of physiological functions. Therefore, it is listed by the World Health Organization (WHO) as one of the six major indicators for evaluating human growth and nutritional status, and it has important value in the fields of clinical medicine, feed processing, food industry and cosmetics manufacturing. [0003] The preparation of riboflavin by microbial fermentation is a very economical and effective method. Compared with other methods for preparing riboflavin, the preparation of riboflavin by microbial fermentation has low cost and less pollution. At present, the largest producers of riboflavin in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D475/14
CPCC07D475/14
Inventor 郭韶智陈志远黎艳华柯伯雄伍文俊
Owner HUBEI GUANGJI PHARMA
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