Solvent of artesunate for intramuscular injection

A technique of artesunate and intramuscular injection, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, organic active ingredients, etc., and can solve problems such as lack of availability

Inactive Publication Date: 2018-07-24
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because Piroplasma lives in the blood of animals, only by maintaining a higher blood concentration and a longer period of plateau concentration can it produce a good killing effect on Piroplasma, but the existing artesunate The administration method does not have this effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The following are examples of the present invention.

[0009] The composition of the special artesunate dissolving agent for animals of the present invention is: 20% propylene glycol, 15% ethanolamine, 15% polyvinylpyrrolidone-K15, 50% sterilized water for injection, and the ratios are volume ratios.

[0010] Mix the above ingredients evenly, filter through a G4 vertical fused glass funnel to obtain a light yellow transparent liquid, divide it, add stoppers, press caps, and sterilize at 121 lbs for 15 minutes.

[0011] 1. Dissolution test

[0012] Take 2 mL of the diluted solution after sterilization and put it into an ampoule, add 0.2 g of artesunate powder, and shake to obtain a light yellow transparent solution, which is completely dissolved.

[0013] 2. Safety test

[0014] 2.1 Dilution muscle irritation test (rabbit quadriceps method)

[0015] Take 4 healthy and uninjured rabbits (body weight more than 2kg), respectively inject 2.0ml of diluent into the quadrice...

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PUM

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Abstract

The invention discloses a solvent of artesunate for intramuscular injection, and particularly relates to a solvent of artesunate for intramuscular injection, which has a slow release function and is used by animals. The solvent is prepared from the following components in percentage by volume: 20% of 1,2-propanediol, 15% of ethanolamine, 15% of polyvinylpyrrolidone-K15, and the balance of sterilewater for injection. The solvent can realize high solubility and safety of artesunate well, has the advantage of slow release at the same time, can maintain effective plasma drug concentration of a drug for a long time in an organism, and reduces the times of drug administration; and compared with oral administration and intravenous injection, the intramuscular injection is easier to operate in veterinary clinical practice.

Description

technical field [0001] The invention relates to a solvent for artesunate for intramuscular injection. Background technique [0002] Artesunate is the first new anti-malarial drug created by Chinese scientists to inherit and carry forward the medical heritage of the motherland. It is one of the most important scientific research achievements in the field of medical science in China since the founding of the People's Republic of my country, and it is also a key new drug vigorously promoted by the World Health Organization. my country's veterinary community uses it to treat blood parasitic diseases such as piriplasmosis (pyroplasmosis) in cattle, sheep, and horses, and has achieved good results. The route of administration is oral or intravenous injection. Artesunate is easily soluble in chloroform, soluble in acetone, slightly soluble in methanol or ethanol, and almost insoluble in water; it can be dissolved with 5% sodium bicarbonate injection for intravenous injection. The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/357A61K47/18A61K47/10A61K47/32A61P33/02
Inventor 罗永江郑继芳辛蕊华王贵波李建喜程富胜
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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