A liquid phase mineralization precursor and method for repairing demineralized dentin

A precursor and liquid-phase technology, applied in dentistry, dental prosthesis, pharmaceutical formulations, etc., can solve problems such as high recurrence rate, unsatisfactory long-term stability, darkening of the face and erosive gums, etc. Achieve long-term stability and simple system

Active Publication Date: 2020-02-14
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The current sealing methods can be divided into in-situ deposition method, fluorine-induced mineralization method, nano-particle packing method, adhesive covering method and laser melting method according to the mechanism. At present, various methods have achieved good curative effect in the clinical or experimental research stage. , but due to insufficient acid resistance, insufficient penetration of the material into the dentinal tubules, or high recurrence rate, its long-term stability is not ideal
For example, Imai et al. used calcium ions and phosphate radicals to deposit in situ in an alkaline environment to form insoluble calcium phosphate salts, but calcium phosphate crystals did not penetrate deep into the dentin tubules; treated with silver ammonium fluoride with a mass fraction of 38% After the dentin, it can promote the formation of protein silver and calcium chloride and produce remineralization, but the side effects such as blackening of the face, ammonia odor and corrosion to the gums are obvious; the nano-gold particle filling method has good clinical application promising but expensive

Method used

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  • A liquid phase mineralization precursor and method for repairing demineralized dentin
  • A liquid phase mineralization precursor and method for repairing demineralized dentin
  • A liquid phase mineralization precursor and method for repairing demineralized dentin

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Embodiment 1

[0035] (1) Add 5g CaCO 3 Suspend the powder in 1L of distilled water, pass CO at room temperature 2 Gas 2h. Filter excess CaCO 3 , and then CO was introduced at room temperature 2 Gas 30min.

[0036] (2) Measure and adjust Ca 2+ At a concentration of 4mM, add PAA and MgCl 2 powder, the concentrations are 20 μg / mL and 12 mM respectively, and mixed uniformly to obtain calcium carbonate mineralization precursor solution.

[0037] (3) Collect caries-free isolated teeth, and cut dentin slices with a thickness of 1 mm perpendicular to the long axis of the teeth with an Isomet slow slicer. The exposed dentin slices were polished with 600-grit SiC sandpaper for 60 s to produce a standard smear layer. The obtained dentin slices were soaked in 0.5M EDTA solution (pH 7.4) for 5 min, then rinsed with a large amount of distilled water, and ultrasonically treated for 1 min to obtain a dentin demineralization model.

[0038] (4) Take 250 mL of the calcium carbonate mineralization pre...

Embodiment 2

[0043] (1) Add 5g CaCO 3Suspend the powder in 1L of distilled water, pass CO at room temperature 2 Gas 2h. Filter excess CaCO 3 , and then into CO 2 Gas 30min.

[0044] (2) Measure and adjust Ca 2+ At a concentration of 3 mM, add pAsp and MgCl 2 powder, the concentrations are 30 μg / mL and 10 mM respectively, and mixed uniformly to obtain calcium carbonate mineralization precursor solution.

[0045] (3) Collect caries-free isolated teeth, and cut dentin slices with a thickness of 1 mm perpendicular to the long axis of the teeth with an ISOMET slow slicer. The exposed dentin slices were polished with 600-grit SiC sandpaper for 60 s to produce a standard smear layer. The obtained dentin slices were soaked in 0.5M EDTA solution (pH 7.4) for 5 min, then rinsed with a large amount of distilled water, and ultrasonically treated for 1 min to obtain a dentin demineralization model.

[0046] (4) Take 250 mL of the calcium carbonate mineralization precursor solution synthesized i...

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Abstract

The invention discloses a liquid-phase mineralizing precursor and a method of repairing demineralized dentine and belongs to the technical field of biomaterials. The liquid-phase mineralizing precursor can repair the demineralized dentine and is a calcium carbonate mineralizing precursor solution containing a polymer and magnesium ions, wherein the concentration of the polymer is 5-100 [mu]g / mL, concentration of Ca<2+> is 1-15 mM, and molar ratio of Mg<2+> to Ca<2+> is 1-6:1. A preparation method of the liquid-phase mineralizing precursor includes steps of: suspending CaCO3 powder in distilledwater and feeding CO2 gas for 1-4 h at room temperature; filtering away residual CaCO3 and feeding CO2 gas for 15-60 min at room temperature; measuring the concentration of Ca<2+> and adding distilled water to regulate the concentration of Ca<2+>; adding the polymer and MgCl2 powder and uniformly mixing the mixture. The liquid-phase mineralizing precursor employs easy-to-obtained raw material andhas simple system, and is a creative break for therapy on oversensitive dentine.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a liquid-phase mineralization precursor and a method for repairing demineralized dentin. Background technique [0002] Dentin exposure is common in tooth wear, abrasion, trauma, caries or tooth preparation. The exposed dentin will produce intermittent irritation pain when exposed to external stimuli. This symptom is dentin sensitivity, which is a frequent occurrence in adults. disease. According to hydrodynamics, reducing the diameter of dentinal tubules and closing the opening of dentinal tubules can effectively reduce the permeability of dentin, thereby achieving the effect of treating dentin sensitivity. Therefore, sealing dentinal tubules is an effective treatment method, and it is also one of the mainstream directions of current research. [0003] The current sealing methods can be divided into in-situ deposition method, fluorine-induced mineraliza...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/80A61K6/887
CPCA61K6/80A61K6/887C08L33/02
Inventor 蒋滔王曼王贻宁
Owner WUHAN UNIV
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