Nano-hydroxyapatite particle with anti-tumor effect, as well as preparation method and application

Abstract

The invention belongs to the field of biomedical materials, and particularly relates to a nano-hydroxyapatite particle with an anti-tumor effect, as well as a preparation method and application. The nano-hydroxyapatite particle is in a long rod shape, has the average diameter being 10 to 50nm, the average length being 20 to 100nm, the average length-diameter ratio being 2 to 10, and the average crystallinity being 30 to 80 percent, and is uniform in particle size distribution. The invention provides the nano-hydroxyapatite particle with controllable crystallinity, which has a higher anti-proliferative effect on tumor cells; 200 to 300mug/ml of nano-hydroxyapatite with the crystallinity being 55 to 70 percent and melanoma cells are co-cultured, so that the cellular proliferation inhibitionrate can reach to 55 percent or above, and a remarkable progress is achieved compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method and application of nano-hydroxyapatite particles with antitumor effects. Background technique [0002] Hydroxyapatite is the main inorganic component in human bones and tissues. It has the advantages of adsorption, high binding, good biocompatibility, good loading capacity, and controllable release to various protein and nucleic acid molecules. It has been widely used It is used in biomedical fields, such as hard tissue repair materials, drug carriers, gene carriers, etc. [0003] In addition, more and more studies have pointed out that nano-hydroxyapatite particles can induce apoptosis of tumor cells and have certain anti-tumor ability. For example, Qing Fangzhu and others prepared nano-hydroxyapatite particles (HA-NPs) with a particle size of 30-60nm and an average particle size of 40nm by a hydrothermal reaction method, and found that they ...

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Problems solved by technology

[0005] The above studies have revealed that the toxic effect of nano-hydroxyapatite particles on tumor cells is related to its particle shape, size, concentration, and ac

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