Surface-enhanced Raman scattering substrate and preparation method thereof
A surface-enhanced Raman and substrate technology, used in Raman scattering, material excitation analysis, instruments, etc., can solve problems such as affecting the detection effect, complex preparation methods, affecting the distribution of the molecules to be measured, etc., achieving strong controllability and preparation. Simple method, strong Raman enhancement effect
Active Publication Date: 2020-06-26
HUNAN UNIV
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Problems solved by technology
[0003] The technical problem solved by the present invention is that in the current method for preparing the SERS substrate at the interface, the disadvantage is that it is necessary to add an inducer or to modify the surface of the nanoparticle, so the preparation method is relatively complicated, and the surface modification of the particle will affect the concentration of the molecule to be tested. distribution thus affecting its detection effect
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Embodiment 1
[0035] The preparation method of gold-graphene nanocapsule substrate comprises the steps:
[0036] (1) 10.8 mL of HAuCl with a concentration of 10 mg / mL 4 The solution was mixed with 80mL methanol and ultrasonically dispersed for 0.5h to obtain solution A; 1g SiO 2 Add 80mL of methanol and sonicate for 1-2h to obtain solution B; mix A solution and B solution and then perform sonication for 1-2h to remove methanol, and dry the obtained mixture at 45-55°C; step (1) Ultrasonic treatment described in refers to ultrasonic treatment under the condition of 180w;
[0037] (2) Grinding the solid obtained in step (1) into powder in CH 4 The flow rate is 150cm 2 Ignite for 8-12min under the airflow condition of / mL, and the burning temperature is 800-1000°C. After cooling, use a mixed solution composed of HF, ethanol and water to etch silicon dioxide, 1000rpm, and wash with water for 3min under the condition of centrifugal washing until the solution is in the middle. properties, after ...
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Abstract
The invention discloses a surface enhanced Raman scattering substrate and a preparation method thereof. The method comprises the following steps: (1), uniformly mixing liquid phase A, liquid phase B and gold-graphene composite nanoparticles, wherein the liquid phase A and the liquid phase B cannot dissolve each other; (2), allowing the liquid phase A and the liquid phase B to stand still, to ensure that the liquid phase A and the liquid phase B are layered, and ensure that the gold-graphene composite nanoparticles are positioned in the interface between the liquid phase A and the liquid phaseB, so that the surface enhanced Raman scattering base is obtained. The surface enhanced Raman scattering base realizes simultaneous detection on multiphase analyte by gold-graphene composite nanoparticle base in the interface and quantitative detection on single analyte in multiple phases, and is simple in method, and high in accuracy.
Description
technical field [0001] The invention relates to a surface-enhanced Raman scattering substrate and a preparation method thereof, belonging to the application field of nanometer materials. Background technique [0002] There is an increasing need for fast and accurate analysis of food, pharmaceuticals and the environment. However, real samples are often mixtures, which contain multiple components and are distributed in different phases (eg, aqueous phase, organic phase), which brings challenges to the analysis of a specific component of the sample. Accurate and sensitive detection of analytes in some complex systems is difficult because the signals of these analytes are easily masked by impurities or other coexisting molecules. Surface-enhanced Raman scattering (surface-enhanced Raman scattering, SERS) is considered to be an ultrasensitive label-free molecular detection method. Due to the rich fingerprint information, high sensitivity and narrow half-peak width of SERS, SERS...
Claims
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IPC IPC(8): G01N21/65G01N21/01
CPCG01N21/01G01N21/658
Inventor 陈卓刘芳谭蔚泓张良
Owner HUNAN UNIV