Marker for pancreatic cancer and intraductal papillary mucinous tumors

A papillary, mucinous technique for evaluating the metastasis of pancreatic cancer cells, which can solve the problems of low sensitivity and poor usefulness of CA19-9

Active Publication Date: 2018-08-21
NAT UNIV CORP KOCHI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, especially in the diagnosis of early pancreatic cancer, there is a problem that CA19-9 has low sensitivity and poor usefulness

Method used

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  • Marker for pancreatic cancer and intraductal papillary mucinous tumors
  • Marker for pancreatic cancer and intraductal papillary mucinous tumors
  • Marker for pancreatic cancer and intraductal papillary mucinous tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Example 1: Identification of pancreatic cancer cell proteins that can be used as pancreatic cancer markers

[0106] The inventors of the present invention conducted studies for the purpose of elucidating the mechanism of invasion and metastasis of pancreatic cancer cells, and found that insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) binds to a specific mRNA, protruding from the cell membrane in the lamellipodia ( lamellipodia) are involved in the local translation of these mRNAs (reported in Oncotarget, 5, pp. 6832-45 (2014)). Among these mRNAs, mRNAs of SCGB1D2 and PODXL were also included (unpublished). Here, functional analysis of SCGB1D2 and PODXL was performed.

[0107] First, in order to investigate whether SCGB1D2 and PODXL, which are locally translated into proteins, exist locally in the lamellipodia of pancreatic cancer cells, immunocytostaining was performed using the human pancreatic cancer cell line S2-013. The result is expressed in figure...

Embodiment 2

[0110] Example 2: Diagnostic Test

[0111] (1) Selection of subjects

[0112] Based on 23 cases of pancreatic cancer (1 case of Stage I pancreatic cancer, 5 cases of Stage III pancreatic cancer, 17 cases of Stage IV advanced pancreatic cancer) and benign tumors of IPMN (intraductal papillary papillary tumor) diagnosed in the Department of Gastroenterology, Kochi University Medical Center Affiliated Hospital Mucinous tumor) cases were carried out on 11 cases. IPMN cases are for patients with no history of cancer and no surgery. As a control, a total of 51 cases of chronic hepatitis, colorectal polyps, and gastric polyps without pancreatic diseases were selected at the Department of Gastroenterology, Affiliated Hospital of Kochi University School of Medicine. The inventors of the present invention and two Japanese Gastroenterological Society supervisors who diagnose and treat pancreatitis use an explanatory document approved by the Clinical Trial Review Committee of Kochi Univ...

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Abstract

The purpose of the present invention is to provide a marker that indicates pancreatic cancer and intraductal papillary mucinous tumors, with high sensitivity and specificity. Furthermore, the purposeof the present invention is also to provide a diagnostic kit for pancreatic cancer and intraductal papillary mucinous tumors, which detects this marker, and a method for evaluating metastatic pancreatic cancer and intraductal papillary mucinous tumors, using the marker. This marker of pancreatic cancer and intraductal papillary mucinous tumors is characterized by including one or more proteins, selected from the group consisting of secretoglobin family-1D member 2, and podocalyxin-like protein. Furthermore, this diagnostic kit for pancreatic cancer and intraductal papillary mucinous tumors ischaracterized by including an antibody for one or more proteins selected from the group consisting of secretoglobin family-1D member 2, and podocalyxin-like protein.

Description

technical field [0001] The present invention relates to a marker showing high sensitivity and specificity for pancreatic cancer and intraductal papillary mucinous tumor, a diagnostic kit for detecting the marker for pancreatic cancer and intraductal papillary mucinous tumor, and the use of the marker A method for assessing the metastasis of pancreatic cancer cells. Background technique [0002] "Tumor" refers to abnormally proliferating cells that continue to proliferate even when the cause of the abnormal growth disappears or is resected. Among tumors, benign tumors proliferate slowly and do not metastasize. Therefore, generally speaking, resection is enough, and even if it is not resected, there is no need to worry about life. On the other hand, malignant tumors, or cancers, are different from benign tumors in that they not only proliferate rapidly, but also proliferate and metastasize to lymph nodes and other organs. Therefore, it is hypothesized that even after surgic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47C12N15/09G01N33/53G01N33/68
CPCC07K14/47G01N33/57438C07K14/70596G01N33/57484G01N33/6893G01N2800/7028G01N2800/52C12N15/09C07K16/303C12Q1/6886C12Q2600/106C12Q2600/112C12Q2600/118C12Q2600/156C12Q2600/158
Inventor 谷内惠介
Owner NAT UNIV CORP KOCHI UNIV
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