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A kind of stannous sulfide nano photothermal agent and preparation method thereof

A technology of stannous sulfide and stannous sulfide block, which is applied in chemical instruments and methods, nanotechnology, nanotechnology, etc., can solve the problem that the photothermal treatment effect of precious metal photothermal agents is not obvious, and the market application of precious metal photothermal agents is limited. Complex preparation process and other problems, to achieve the effects of abundant raw materials, obvious photothermal effect, and simple preparation process

Active Publication Date: 2020-08-18
SHENZHEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these photothermal agents have their own shortcomings. The photothermal properties of gold and other precious metals mainly come from the surface plasmon resonance effect, and this effect is affected by the surface morphology, size, and dielectric constant of the surrounding medium. The impact is so great that the actual photothermal treatment effect of noble metal photothermal agents is not obvious; in addition, the high price also limits the market application of noble metal photothermal agents
However, carbon materials have disadvantages such as complicated preparation process and low absorption coefficient at 808nm.

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  • A kind of stannous sulfide nano photothermal agent and preparation method thereof
  • A kind of stannous sulfide nano photothermal agent and preparation method thereof
  • A kind of stannous sulfide nano photothermal agent and preparation method thereof

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preparation example Construction

[0034] The second aspect of the embodiment of the present invention provides a method for preparing a stannous sulfide nano-photothermal agent, comprising the following steps:

[0035] After grinding the stannous sulfide block for 20-60 minutes, dispersing it in an organic solvent to obtain a dispersion;

[0036] Sonicate the dispersion in a water bath at 5°C-10°C for 8-12 hours to obtain an ultrasonicated dispersion;

[0037] After the ultrasonic dispersion liquid is centrifuged, the precipitate is collected and dried to obtain stannous sulfide quantum dots.

[0038] In the embodiment of the present invention, the dispersion liquid is ultrasonicated in a water bath at 10° C. for 8-12 hours.

[0039] In the embodiment of the present invention, the organic solvent includes one or both of isopropanol and nitrogen methyl pyrrolidone, and the mass concentration of stannous sulfide in the dispersion is 0.5-5 mg / mL, that is, stannous sulfide block After grinding, the mass concentr...

Embodiment 1

[0049] A preparation method of stannous sulfide nano photothermal agent, comprising the following steps:

[0050] (1) After grinding the stannous sulfide block for 30 minutes, disperse it in isopropanol to obtain a dispersion with a concentration of 1 mg / mL;

[0051] (2) Ultrasonic the above-mentioned dispersion liquid with a probe for 5 hours, the probe power of the probe ultrasonic is 360w, and the temperature of the probe is kept at 5-10°C during the ultrasonic process, and when the temperature rises during the period, use an ice pack to cool down;

[0052] (3) Ultrasonic the dispersion in a water bath for 8 hours to obtain the ultrasonic dispersion, and keep the temperature of the ultrasonic in the water bath at 5-10°C;

[0053] (4) Centrifuge the ultrasonically dispersed liquid at a speed of 15,000 rpm for 0.5 h, take the supernatant, then centrifuge the supernatant at a speed of 20,000 rpm for 0.5 h, collect the precipitate, and dry , to obtain tin sulfide quantum dots;...

Embodiment 2

[0057] A preparation method of stannous sulfide nano photothermal agent, comprising the following steps:

[0058] (1) After grinding the stannous sulfide block for 40 minutes, disperse it in nitrogen methyl pyrrolidone to obtain a dispersion with a concentration of 1 mg / mL;

[0059] (2) Ultrasonic the above-mentioned dispersion liquid with a probe for 8 hours, the probe power of the probe ultrasonic is 150w, and the temperature is kept at 10-10°C during the ultrasonic probe process, and when the temperature rises during the period, use an ice pack to cool down;

[0060] (3) Ultrasonic the dispersion in a water bath for 12 hours to obtain the ultrasonic dispersion, and keep the temperature of the ultrasonic in the water bath at 5-10°C;

[0061] (4) After centrifuging the ultrasonically dispersed liquid, centrifuge at a speed of 13,000 rpm for 1 hour, take the supernatant, then centrifuge the supernatant at a speed of 18,000 rpm for 1 hour, collect the precipitate, and dry it to...

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Abstract

Disclosed is a stannous sulfide nanometer photo-thermal agent, comprising stannous sulfide quantum dots. The preparation method therefor comprises: grinding a stannous sulfide block for 20-60 minutes, and then dispersing same in an organic solvent to obtain a dispersion; sonicating the dispersion in a water bath at 5ºC-10ºC for 8-12 hours so as to obtain a sonicated dispersion; and centrifuging the sonicated dispersion, and then collecting a precipitate and drying same to obtain stannous sulfide quantum dots. The stannous sulfide nanometer photo-thermal agent has a distinct photo-thermal effect, a high chemical stability and a low toxicity; the raw materials thereof are abundant, the price thereof is cheap, and the preparation method therefor is simple; and same has a broad application prospect in the field of photo-thermal therapy. The preparation method uses raw materials which are easy to obtain, has a sample preparation process, and easily achieves large-scale production.

Description

technical field [0001] The invention relates to the technical field of nano photothermal agents, in particular to a stannous sulfide nano photothermal agent and a preparation method thereof. Background technique [0002] In recent years, photothermal therapy, as a new type of cancer therapy, has attracted widespread attention. It mainly uses photothermal agents to generate local high temperature under the irradiation of 808nm laser to kill cancer cells, with few side effects and high efficiency. [0003] At present, more photothermal agents have been studied, including precious metals such as gold, silver, and platinum, and carbon materials such as graphene, graphene oxide, and carbon nanorods. However, these photothermal agents have their own shortcomings. The photothermal properties of gold and other precious metals mainly come from the surface plasmon resonance effect, and this effect is affected by the surface morphology, size of the nanostructure, and the dielectric con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/10C01G19/00A61P35/00B82Y40/00
CPCA61K41/0052A61K47/10A61P35/00B82Y40/00C01G19/00C01P2004/64B82Y15/00C01P2004/04
Inventor 张晗谢中建范涛健
Owner SHENZHEN UNIV
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