Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of composite medical bio-bone cement and its preparation method and application

A bone cement and composite technology, applied in the field of composite medical bio-bone cement and its preparation, can solve the problems of non-degradable absorption, high elastic modulus of bone cement, nerve tissue damage, etc.

Active Publication Date: 2020-10-23
SUN YAT SEN UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, polymethylmethacrylate (PMMA) bone cement is widely used in clinic because of its good operability, biocompatibility, chemical stability and good mechanical properties, but polymethylmethacrylate (PMMA) ) bone cement has a single function, only relying on its mechanical strength to play a supporting role, and polymethyl methacrylate bone cement has a high elastic modulus, and it is not degradable and absorbable in the body. Damage to nerve tissue surrounding the injury site due to cement leakage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of composite medical bio-bone cement and its preparation method and application
  • A kind of composite medical bio-bone cement and its preparation method and application
  • A kind of composite medical bio-bone cement and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A composite medical bio-bone cement, comprising a powder part and a liquid part with a weight ratio of 1:1, and the powder part, in parts by weight, comprises sodium alendronate-nano hydroxyapatite (ALN-HA ) powder 0.4g, polymethyl methacrylate powder (PMMA) 0.6g with a number average molecular weight of 500,000-700,000, and 0.03 g of dibenzoyl peroxide (BPO); Limestone powder (ALN-HA) was prepared as follows: Alendronate sodium (ALN) dissolved in ultrapure water was added to nano-hydroxyapatite (nHA), and the mixture of alendronate sodium and nano-hydroxyapatite The mass ratio is 0.01-0.2, stirred at 90°C for 5 hours, freeze-dried for 72 hours, and ground to obtain the target product. For its infrared spectrum, see figure 1 ; When the mass ratio of sodium alendronate and nano-hydroxyapatite is 0.2, that is, when the degree of modification of ALN in ALN-HA is 20%, the experimental thermogravimetric analysis results are as shown in Figure 2; the liquid part includes 0.0...

Embodiment 2

[0028] Referring to Example 1, the difference is that the weight ratio of the powder part to the liquid part is 1:1.5, 0.45 g of alendronate sodium-nano hydroxyapatite (ALN-HA) powder, and a number average molecular weight of 500,000-700,000 Polymethyl methacrylate powder (PMMA) 0.45g, dibenzoyl peroxide (BPO) 0.04g.

[0029] Compressive strength: According to the ISO5833 bone cement standard, a 12mm×6mm cylindrical specimen was prepared, and after curing at a constant temperature of 37°C for 24 hours, the compressive strength was measured with an AGS-10KN universal testing machine (AGS-10KN, UniversalTesting Machines, Shimadzu, Japan). The results show that the mechanical properties of the bone cement obtained by the present invention are up to the standard.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses composite type medical biological bone cement. The composite type medical biological bone cement comprises a powder part and a liquid part in the mass ratio of (1: 1) to (1: 1.5); in parts by weight, the powder part comprises 40 to 45 parts of alendronate sodium-nano-hydroxyapatite powder, 45 to 60 parts of polymethyl methacrylate powder with the polymethyl methacrylate of0.5 to 0.7 million and 3 to 4 parts of dibenzoyl peroxide. The alendronate sodium-nano-hydroxyapatite powder is used for greatly improving the biocompatibility of PMMA bone cement, the mineralizationof the bone cement is promoted, the bone cement can be preferably combined with bone, the bone conduction effect and bone induction effect of the bone cement can be used for effectively promoting thegrowth of bone, simultaneously, the contained alendronate sodium is used for effectively resisting osteoporosis, the activity of osteoclasts is inhibited, and the bone absorption is reduced.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a composite medical bio-bone cement and its preparation method and application. Background technique [0002] At present, polymethylmethacrylate (PMMA) bone cement is widely used in clinic because of its good operability, biocompatibility, chemical stability and good mechanical properties, but polymethylmethacrylate (PMMA) ) bone cement has a single function, only relying on its mechanical strength to play a supporting role, and polymethyl methacrylate bone cement has a high elastic modulus, and it is not degradable and absorbable in the body. Cement leakage causes damage to the nerve tissue surrounding the injury site. Contents of the invention [0003] The purpose of the present invention is to provide a composite medical bio-bone cement, which can realize the function of self-expansion under the premise of reducing the total amount of bone cement, has better tissue com...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/663A61L27/46A61L27/58
CPCA61L27/46A61L27/58A61L2300/216A61L2300/412A61L2300/604C08L33/12
Inventor 熊柯张超谢妍蒋庆
Owner SUN YAT SEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com