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Militarine and application thereof in preparation of hemostasis medicines

A kind of medicine and technology, which is applied in the application field of Baiji glucoside in the preparation of hemostatic drugs, can solve problems such as excessive blood coagulation, long hemostasis time, and inconspicuous hemostatic effect, etc., and achieve good application prospects and high clinical application value Effect

Inactive Publication Date: 2018-10-02
GUIZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most commonly used hemostatic drugs face many defects such as complex components, long hemostatic time, ineffective hemostatic effect, easy to cause excessive coagulation and other physiological effects, poor biological safety, etc., and cannot fully meet the clinical needs

Method used

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  • Militarine and application thereof in preparation of hemostasis medicines
  • Militarine and application thereof in preparation of hemostasis medicines
  • Militarine and application thereof in preparation of hemostasis medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The formulation and preparation method of tablet in the pharmaceutical dosage form of embodiment 1 bletachin hemostatic drug

[0023] In the hemostatic drug of bletilla glucoside, the tablet is made of the following raw materials: 10 g bletilla glucoside, 20 g starch, 20 g maltose, an appropriate amount of talcum powder, an appropriate amount of 10% starch paste, and an appropriate amount of water for injection, and a total of 100 tablets are made.

[0024] The preparation method of the tablet: take bletilla glucoside, pulverize and sieve it, add starch, maltose and other pharmaceutical excipients, use wet granulation, add talcum powder and other lubricants after drying and granulating, and press conventional methods to obtain the tablet of the present invention. Hemostatic tablets.

[0025] The above-mentioned preparation method is specifically to take bletilla glucoside, starch, and maltose to pass through a 100-mesh sieve, mix the three evenly, and then use a wet gra...

Embodiment 2

[0026] Formula and preparation method of freeze-dried powder injection in the pharmaceutical dosage form of embodiment 2 bletachin hemostatic drug

[0027] Among the hemostatic drugs of bletachin, the freeze-dried powder injection is made of the following raw materials: 100g of bletachin, 50g of mannitol, and 1000ml of water for injection.

[0028] The preparation method of the freeze-dried powder injection is as follows: dissolving the above-mentioned mannitol in water for injection, stirring in a constant temperature water bath magnetic stirrer at a stirring temperature of 40-50° C. until all the mannitol is dissolved to obtain a mannitol solution. Lower the temperature of the mannitol solution to 20°C, then add the brigandigin, keep the temperature at 20°C and continue to stir until it is completely dissolved, dilute to volume with an appropriate amount of water for injection, and adjust the pH value of the solution to about 7.0. The above solutions were circulated and filt...

Embodiment 3

[0030] The influence of embodiment 3 bletilla glycosides on the coagulation time of rabbits

[0031] (1) Purpose of the experiment: In vitro coagulation test of rabbits was used to determine the coagulation time to determine the hemostatic effect of glucoside.

[0032] (2) Experimental object: rabbit

[0033] (3) Animal grouping and administration: Take 10 mg of Yunnan Baiyao and 1 mg of Baiji glucoside, add two drops of DMSO to dissolve, place in a 1 mL EPP tube, add PBS (pH=7.4) solution to 1 mL, and the blank group is PBS (pH=7.4). 7.4). Each group took 0.2mL of the solution and placed it in a glass tube with a diameter of 1.5cm and a length of 10cm, and placed it in a water bath box at 37°C for 2 minutes. Take 10mL of arterial blood from the right common carotid artery of rabbits, add 2mL of rabbit blood to the above test tubes, mix well, then take a water bath, tilt the glass tube every 10s until the blood coagulates and stops flowing, record the coagulation time, and m...

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Abstract

The invention discloses militarine and an application thereof in preparation of hemostasis medicines, wherein the militarine has significant hemostatic effect under bleeding status, and can achieve the equivalent hemostatic effect as Yunnan Baiyao just at the usage amount of 10% of the Yunnan Baiyao. What is more, under normal status, the militarine does not show the hemostatic effect but shows certain blood activation effect, which has important significance on possibility of improper usage of hemostasis medicines. The militarine belongs to natural active compounds and will not cause adversereaction, such as allergy, to human body, so that the militarine is safe and toxic-free, can be produced industrially and has great application prospect.

Description

technical field [0001] The invention relates to the application of active ingredients of Chinese medicinal materials, in particular to the application of baiji glucoside in the preparation of hemostatic medicine. Background technique [0002] Bleeding is an important clinical symptom of many internal and surgical diseases, and most of them are critical, urgent and severe. Bleeding is often accompanied by pain and inflammation, and excessive bleeding can lead to shock and even life-threatening. Therefore, hemostasis is a necessary step and an important means to deal with severe clinical hemorrhagic disease. Hemostasis is a complex physiological process, which is mainly affected by important factors such as blood coagulation, platelet aggregation and vasoconstriction. When bleeding occurs due to vascular injury, the tissue's own coagulation mechanism is fully displayed, the activity of prothrombin activator is enhanced, and the formation increases, and then prothrombin is co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K9/20A61P7/04
CPCA61K9/2059A61K31/7034A61P7/04
Inventor 王磊王永林廖尚高赵菲菲何迅鄢艳李勇军周孟徐国波李靖关焕玉黄勇王爱民兰燕宇孙佳
Owner GUIZHOU MEDICAL UNIV
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