Compound antiseptic containing natamycin and application of compound antiseptic
A compound antiseptic and natamycin-containing technology, which is applied in the field of preservatives, can solve the problems of limited approval and satisfaction, increased preservative dosage, skin irritation and damage, etc., to achieve simple use and inhibit mold Production of toxins, wide range of effects
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Embodiment 1
[0024] Embodiment 1, preferred compound preservative formula among the present invention is:
[0025] 1) The weight ratio of natamycin:propylene glycol=0.8:99.2, that is, the components and weight content of the compound preservative are: 0.8% natamycin, 99.2% propylene glycol.
[0026] 2) The weight ratio of natamycin: pentylene glycol = 0.8:99.2, that is, the components and weight content of the compound preservative are: 0.8% natamycin, 99.2% pentylene glycol.
[0027] 3) The weight ratio of natamycin:butanediol=0.8:99.2, that is, the components and weight content of the compound preservative are: 0.8% natamycin and 99.2% butanediol.
[0028] 4) The weight ratio of natamycin:phenoxyethanol=0.4:99.6, that is, the components and weight content of the compound preservative are: 0.4% natamycin and 99.4% phenoxyethanol.
[0029] 5) The weight ratio of natamycin: caprylyl glycol = 0.6:99.4, that is, the components and weight content of the compound preservative are: 0.6% natamyc...
Embodiment 2
[0044] Embodiment 2, laboratory inhibition zone experiment
[0045] The zone of inhibition test can effectively reflect the strength of antibacterial activity of preservatives. The compound preservative aqueous solution prepared by formula 1-19 was used as the experimental object, and Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, and Candida albicans provided by Shandong Drug Inspection Institute were used as experimental objects. Experimental strains. Soak a circular filter paper piece with a diameter of 6mm in the corresponding concentration of preservative aqueous solution for 30 minutes, take it out and drain it, and place it on the culture medium that has been evenly coated with microorganisms. Measure the diameter of the inhibition zone after 36 hours. The larger the diameter, the greater the inhibition. The stronger the bacteria.
[0046] Table 1. Experimental data of the control group
[0047] formula ...
Embodiment 3
[0054] Embodiment 3, microbiological experiment:
[0055] This experiment objectively reflects the strength of the anti-corrosion system formed by preservatives in the product. The stronger the anti-corrosion system, the less likely the product will deteriorate and be less likely to suffer from secondary pollution during use.
[0056] The bacteria and molds used in the test were provided by Shandong Food and Drug Inspection Institute. Bacteria include: Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Bacillus megaterium, Pseudomonas aeruginosa. Molds include: Aspergillus niger, Aspergillus flavus, Aspergillus versicolor, Penicillium citrinum, Paecilomyces, Cladosporium cerevisiae, Chaetomium globosa, Trichoderma viride.
[0057] Before the experiment, each strain was inoculated in a suitable medium and cultured at 37°C (bacteria) or 28°C (mold). After 2 days of bacterial culture and 3-5 days after mold culture, select an appropriate amount of colonies and place th...
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