Compound antiseptic containing natamycin and application of compound antiseptic

A compound antiseptic and natamycin-containing technology, which is applied in the field of preservatives, can solve the problems of limited approval and satisfaction, increased preservative dosage, skin irritation and damage, etc., to achieve simple use and inhibit mold Production of toxins, wide range of effects

Inactive Publication Date: 2014-12-17
广州艾卓生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these traditional preservatives have been used for a long time, and microorganisms have more or less developed corresponding drug resistance, so the amount of these preservatives has gradually increased
In addition, most of these traditional preservatives are irritating and harmful to the body and skin, which greatly limits their recognition and satisfaction in the minds of consumers.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, preferred compound preservative formula among the present invention is:

[0025] 1) The weight ratio of natamycin:propylene glycol=0.8:99.2, that is, the components and weight content of the compound preservative are: 0.8% natamycin, 99.2% propylene glycol.

[0026] 2) The weight ratio of natamycin: pentylene glycol = 0.8:99.2, that is, the components and weight content of the compound preservative are: 0.8% natamycin, 99.2% pentylene glycol.

[0027] 3) The weight ratio of natamycin:butanediol=0.8:99.2, that is, the components and weight content of the compound preservative are: 0.8% natamycin and 99.2% butanediol.

[0028] 4) The weight ratio of natamycin:phenoxyethanol=0.4:99.6, that is, the components and weight content of the compound preservative are: 0.4% natamycin and 99.4% phenoxyethanol.

[0029] 5) The weight ratio of natamycin: caprylyl glycol = 0.6:99.4, that is, the components and weight content of the compound preservative are: 0.6% natamyc...

Embodiment 2

[0044] Embodiment 2, laboratory inhibition zone experiment

[0045] The zone of inhibition test can effectively reflect the strength of antibacterial activity of preservatives. The compound preservative aqueous solution prepared by formula 1-19 was used as the experimental object, and Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, and Candida albicans provided by Shandong Drug Inspection Institute were used as experimental objects. Experimental strains. Soak a circular filter paper piece with a diameter of 6mm in the corresponding concentration of preservative aqueous solution for 30 minutes, take it out and drain it, and place it on the culture medium that has been evenly coated with microorganisms. Measure the diameter of the inhibition zone after 36 hours. The larger the diameter, the greater the inhibition. The stronger the bacteria.

[0046] Table 1. Experimental data of the control group

[0047] formula ...

Embodiment 3

[0054] Embodiment 3, microbiological experiment:

[0055] This experiment objectively reflects the strength of the anti-corrosion system formed by preservatives in the product. The stronger the anti-corrosion system, the less likely the product will deteriorate and be less likely to suffer from secondary pollution during use.

[0056] The bacteria and molds used in the test were provided by Shandong Food and Drug Inspection Institute. Bacteria include: Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Bacillus megaterium, Pseudomonas aeruginosa. Molds include: Aspergillus niger, Aspergillus flavus, Aspergillus versicolor, Penicillium citrinum, Paecilomyces, Cladosporium cerevisiae, Chaetomium globosa, Trichoderma viride.

[0057] Before the experiment, each strain was inoculated in a suitable medium and cultured at 37°C (bacteria) or 28°C (mold). After 2 days of bacterial culture and 3-5 days after mold culture, select an appropriate amount of colonies and place th...

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PUM

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Abstract

The invention discloses a compound antiseptic containing natamycin. The compound antiseptic comprises the following components in percentage by weight: 0.1-2% of a component A and 99.9-98% of a component B, wherein the component B is any one or a mixture of a component C and a component D at any proportion; the component A is natamycin; the component C is propylene glycol, pentanediol or butanediol; and the component D is caprylyl glycol, decamethylene glycol, hexanediol or phenoxyethanol. In daily chemical products, the compound antiseptic is used as an antiseptic additive for preventing corrosion and sterilizing and is capable of effectively preventing bacteria growing in storage and usage processes of the daily chemical products within a shelf life so as to protect the products from going bad or rotting; and the compound antiseptic is safe, efficient and low in irritation.

Description

technical field [0001] The invention relates to a preservative, in particular to a compound preservative containing natamycin used for antibacterial and antiseptic of daily chemical products. Background technique [0002] Since daily chemical products contain a large amount of various active ingredients such as surfactants, oils, and plant extracts, they are very easy to breed microorganisms and cause product spoilage. At the same time, once the product is spoiled, some pathogenic bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella will also breed, and some microorganisms will produce bacterial toxins, which will pose a threat to the personal safety of users. Therefore, the antisepsis and sterilization of daily chemical products is an important control factor to consider. [0003] At present, most daily chemical products on the market use three types of preservatives: formaldehyde sustained-release preservatives and their compound products; parabe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60
Inventor 张晓琮张军
Owner 广州艾卓生物科技股份有限公司
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