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Seasonal flu-RSV-epidemic cerebrospinal meningitis combined vaccine based on recombinant vector protein

A combination vaccine and recombinant vector technology, which is applied in the field of seasonal influenza-RSV-meningococcal combined vaccine, can solve the problems that preventive polysaccharide and/or protein vaccines have not been reported, and achieve good immune effect, extensive immune response, immune strong effect

Inactive Publication Date: 2018-10-09
BRAVOVAX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0019] The application of magnetic nanospheres in biomedicine has become more and more extensive with the deepening of research, including immobilized enzymes, targeted drugs, cell separation and immune analysis, magnetic control detection, etc., and the research of nanospheres in DNA vaccines is also prepared. Attention has been paid to researches on carrier proteins and adjuvants, but there are no reports on its application in prophylactic polysaccharide and / or protein vaccines

Method used

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  • Seasonal flu-RSV-epidemic cerebrospinal meningitis combined vaccine based on recombinant vector protein
  • Seasonal flu-RSV-epidemic cerebrospinal meningitis combined vaccine based on recombinant vector protein
  • Seasonal flu-RSV-epidemic cerebrospinal meningitis combined vaccine based on recombinant vector protein

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Embodiment Construction

[0043] The seasonal influenza-RSV-meningococcal combined vaccine based on the recombinant carrier protein provided by the present invention will be further described in detail and completely in combination with the examples below. The embodiments described below are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

[0044] The experimental methods in the following examples are conventional methods unless otherwise specified. The experimental materials used in the following examples were purchased from the market unless otherwise specified.

[0045] 1. Preparation of Modified Meningococcal Protein Carriers

[0046] 1.1. Cloning and prokaryotic expression of ΔfHbp and ΔfHbp-NadA recombinant proteins

[0047] Such as figure 1 As shown, according to the full-length CDS sequences of fHbp V1 and fHbp V3 registered in GeneBank, the following two pairs of primers were designed: the primers introduced BamHI and HindII...

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Abstract

The invention discloses a seasonal flu-RSV-epidemic cerebrospinal meningitis combined vaccine based on recombinant vector protein. The combined vaccine is the combined vaccine formed by connecting epidemic cerebrospinal meningitis polysaccharide, hemophilus influenzae type b polysaccharide, RSV immunogenic protein and epidemic cerebrospinal meningitis modified vector protein by connecting bodies,wherein the connecting bodies are magnetic nanometer microspheres. The magnetic nanometer microspheres are used as the connecting bodies; the three kinds of immune compounds are connected to generatethe immune reaction in a cooperating way; a good immune effect is generated; the preparation process is simple; good popularization values are realized.

Description

technical field [0001] The invention relates to a seasonal influenza-RSV-meningococcal combined vaccine based on a recombinant carrier protein, belonging to the field of biopharmaceuticals. Background technique [0002] 1. Haemophilus influenzae and its epidemiology [0003] Haemophilus influenzae type b is the most invasive serotype of Haemophilus influenzae, and it is an important pathogenic bacterium that causes severe infections in children. It mainly infects children under the age of 5, especially infants and young children under the age of 2. Hib spreads through the respiratory tract of susceptible individuals and colonizes the nasopharynx. It can be asymptomatically carried for several months, and a small number of people develop Hib invasive disease. The most common diseases of Hib infection are meningitis and pneumonia, and also include osteomyelitis, septic arthritis, epiglottitis and sepsis. The most important virulence factor of Hib is its capsular polysacchari...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/116A61K39/095A61K39/102A61K39/155A61P31/04A61P31/14
CPCA61K39/095A61K39/102A61K39/12A61K2039/6031A61K2039/70A61P31/04A61P31/14C12N2760/18534
Inventor 吴克闫利明刘昊智孙晓东
Owner BRAVOVAX
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