Organic vanadium complexes with insulin mimetic activity, and preparation method thereof
A technology of vanadium complexes and insulin, which is applied in the fields of complex synthesis and medicinal chemistry, and can solve problems such as death, changes in renal function, and high toxicity
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Embodiment 1
[0016] Example 1: Preparation of vanadium complex (complex 1) with (E)-N'-(2-hydroxybenzylidene)-3-methoxybenzohydrazide and ethyl maltol as ligands .
[0017] Salicylaldehyde (1.0 mmol) and 3-methylbenzohydrazide (1.0 mmol) were respectively dissolved in 20 mL of methanol and stirred at room temperature for 30 minutes to obtain a colorless solution. Ethyl maltol (1.0 mmol) and vanadyl(IV) acetylacetonate (1.0 mmol) were then added thereto, and stirring was continued for 30 minutes to obtain a brown solution. The solvent was slowly evaporated from the solution at room temperature, and a dark brown bulk single crystal was obtained after one week. Structural testing was carried out by X-ray single crystal diffraction, and the crystal structure diagram is shown in the attached figure figure 1 As shown, the crystal data are shown in Table 1, and the molecular formula is C 22 h 19 N 2 o 6 V, the structural formula is as follows.
[0018] .
[0019] After analysis, the...
Embodiment 2
[0020] Example 2: Preparation of a vanadium complex (complex 2) using (E)-N'-(2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide as a ligand.
[0021] Salicylaldehyde (1.0 mmol) and 3,5-dimethoxybenzohydrazide (1.0 mmol) were respectively dissolved in 20 mL of methanol and stirred at room temperature for 30 minutes to obtain a colorless solution. Vanadyl(IV) acetylacetonate (1.0 mmol) was then added thereto and stirring was continued for 30 minutes to obtain a brown solution. The solvent was slowly evaporated from the solution at room temperature, and a dark brown bulk single crystal was obtained after one week. Structural testing was carried out by X-ray single crystal diffraction, and the crystal structure diagram is shown in the attached figure figure 2 As shown, the crystal data are shown in Table 1, and the molecular formula is C 18 h 21 N 2 o 7 V, the structural formula is as follows.
[0022] .
[0023] After analysis, the molecular structure of the complex...
Embodiment 3
[0024] Embodiment three: take (E)-N'-(2-ethoxybenzylidene)-3,5-dimethoxybenzoic hydrazide and ethyl maltol as the vanadium complex of ligand (complex Preparation of object 3).
[0025] 3-Ethoxysalicylaldehyde (1.0 mmol) and 3,5-dimethoxybenzohydrazide (1.0 mmol) were respectively dissolved in 20 mL of methanol and stirred at room temperature for 30 minutes to obtain a colorless solution. Ethyl maltol (1.0 mmol) and vanadyl(IV) acetylacetonate (1.0 mmol) were then added thereto, and stirring was continued for 30 minutes to obtain a brown solution. The solvent was slowly evaporated from the solution at room temperature, and a dark brown bulk single crystal was obtained after one week. Structural testing was carried out by X-ray single crystal diffraction, and the crystal structure diagram is shown in the attached figure image 3 As shown, the crystal data are shown in Table 1, and the molecular formula is C 25 h 25 N 2 o 9 V, the structural formula is as follows.
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