Irreversible rhodamine-based ClO<-> fluorescent probe and synthetic method thereof

A technique for fluorescent probes and synthesis methods, applied in the field of irreversible rhodamine-based ClO-fluorescent probes and their synthesis, capable of solving problems such as poor sensitivity, complicated synthesis steps of fluorescent probes, and short excitation wavelengths, achieving high sensitivity and high yield High, easy-to-operate effect
CN108640924AInactive Publication Date: 2018-10-12QUANGANG PETROCHEM RES INST OF FUJIAN NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
QUANGANG PETROCHEM RES INST OF FUJIAN NORMAL UNIV
Publication Date
2018-10-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of biological cell diagnosis and specifically relates to an irreversible rhodamine-based ClO<-> fluorescent probe and a synthetic method thereof. A structural formula of the irreversible rhodamine-based ClO<-> fluorescent probe is as shown in a figure in the specification. The irreversible rhodamine-based ClO<-> fluorescent probe contains a rhodamine fluorophorewith high sensitivity, good light stability, high fluorescent quantum yield and long wavelength. A certain amount of rhodamine lactam and dansyl chloride are subjected to a condensation reaction undercertain conditions to obtain the irreversible rhodamine-based ClO<-> fluorescent probe with a special structure. A synthetic process has simple and easily-available raw materials, mild reaction conditions and simple operation, the obtained rhodamine fluorescent probe can quickly detect ClO<-> in biological cells in an aquatic environment, is free from interference of other ions, belongs to response type identification in combination with the ClO<-> and has irreversibility.
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Description

technical field

[0001] The invention belongs to the field of biological cell diagnosis, in particular to an irreversible rhodamine-based ClO - Fluorescent probes and methods for their synthesis. Background technique

[0002] In recent years, the detection of inorganic anions in the environment, in biological systems and even in medicine has attracted much attention. Active oxygen compounds in inorganic anions play an important role in physiological and pathological processes. Hypochlorite (ClO - ) is a common non-nucleophilic oxidant, the main component of detergents and antibacterial agents widely used in industry and daily life, and the most critical reactive oxygen species (ROS) for the immune system of organisms. In living organisms, hypochlorite (ClO - ) is involved in intracellular redox reactions and various signal transduction processes, including vasodilation, myocardial contraction, neurotransmission, and insulin secretion. And when intracellular hypochlorite ...

Claims

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