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Application of sodium salicylate in the preparation of preparations for promoting liver regeneration

A technology of sodium salicylate and preparations, which is applied in the field of medical use of sodium salicylate, can solve the problems of low induction differentiation efficiency, and achieve the effect of promoting liver regeneration and induction differentiation

Active Publication Date: 2019-10-22
SUZHOU QINGYA QIRUI BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the low efficiency of induction of differentiation has become a bottleneck in the clinical application of hepatocyte transplantation

Method used

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  • Application of sodium salicylate in the preparation of preparations for promoting liver regeneration
  • Application of sodium salicylate in the preparation of preparations for promoting liver regeneration
  • Application of sodium salicylate in the preparation of preparations for promoting liver regeneration

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Experimental program
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Effect test

Embodiment Construction

[0017] An application of sodium salicylate in the preparation of a preparation for promoting liver regeneration.

[0018] The preparation for promoting liver regeneration is a preparation for inducing embryonic stem cells to differentiate into hepatic parenchymal cells.

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Abstract

The invention discloses an application of sodium salicylate in preparing a liver regeneration promoting preparation. According to the invention, induced differentiation of human embryonic stem cells towards parenchymal liver cells can be promoted, so that liver regeneration is promoted.

Description

technical field [0001] The invention relates to a medical application of sodium salicylate. Background technique [0002] Liver transplantation is usually the treatment of acute liver injury and advanced liver disease, but the lack of suitable donors makes this treatment very limited. In recent years, hepatocyte transplantation is a new and important method that can replace liver transplantation, that is, hepatocytes cultured in vitro (mainly hepatic parenchymal cells) are reinfused into patients to restore liver function in patients. At present, hepatic parenchymal cells for reinfusion are mainly induced and differentiated from the following types of cells: pluripotent stem cells (including embryonic stem cells and inducible pluripotent stem cells); mesenchymal stem cells; liver precursor cells or liver stem cells . However, the low efficiency of induction of differentiation has become a bottleneck in the clinical application of hepatocyte transplantation. [0003] Salic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/071C12N5/0735
Inventor 孙诚
Owner SUZHOU QINGYA QIRUI BIOTECHNOLOGY CO LTD
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