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A kind of preparation method of florfenicol nano crystal

A florfenicol and nanocrystal technology is applied in the field of preparation of florfenicol nanocrystals, which can solve the problems of low solubility and drug loading, and achieve the effects of reducing drug residues, reducing pollution and ensuring food safety.

Active Publication Date: 2020-08-25
广东润华药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a preparation method of florfenicol nanocrystals, which overcomes the shortcomings of the above-mentioned preparations, not only solves the problems of low drug solubility and drug loading, but also has the effect of enhancing drug safety and effectiveness, and is highly efficient. The research and development of nanocrystalline veterinary drugs can reduce the dosage of antibiotics, improve the absorption and distribution of drugs in the body, thereby greatly reducing drug residues, ensuring food safety, and reducing environmental pollution

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  • A kind of preparation method of florfenicol nano crystal
  • A kind of preparation method of florfenicol nano crystal
  • A kind of preparation method of florfenicol nano crystal

Examples

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Embodiment 1

[0024] A preparation method of florfenicol nano crystals, comprising the following steps:

[0025] (1) Preparation of florfenicol nanosuspension: Weigh 50 mg of florfenicol and dissolve it in 20 mL of methanol, and dissolve SDS and PVPK30 in a ratio of 5:1 in 40 mL of deionized water by ultrasonic to prepare a concentration of 5mg / mL stabilizer solution, at room temperature, under stirring conditions, slowly drop the florfenicol methanol solution into the stabilizer solution; after dropping, transfer the suspension to a round-bottomed flask, at 40 ° C, reduce Under pressure conditions, methanol was removed by rotary evaporation; the florfenicol nanosuspension can be prepared.

[0026] (2) Ultrasonic crushing method: crush the florfenicol nano-suspension prepared in step (1) in an ice bath at 0°C and 300w ultrasonic power for 10 minutes to obtain the florfenicol nano-crystal suspension .

[0027] (3) Spray drying: The florfenicol nanocrystal suspension prepared in step (2) is...

Embodiment 2

[0029] A preparation method of florfenicol nano crystals, comprising the following steps:

[0030] (1) Preparation of florfenicol nanosuspension: weigh 50 mg of florfenicol and dissolve in 20 mL of ethanol, dissolve SDS and PEG6000 in a ratio of 5:1 in 40 mL of deionized water to prepare a concentration of 5 mg / mL stabilizer solution, at room temperature, under stirring conditions, slowly drop florfenicol ethanol solution into the stabilizer solution; after dropping, transfer the suspension to a round bottom flask, and remove it by rotary evaporation at 40°C Ethanol; the florfenicol nanosuspension can be obtained.

[0031] (2) Ultrasonic crushing method: crush the florfenicol nano-suspension prepared in step (1) in an ice bath at 10°C in an ultrasonic power of 300 w for 20 minutes to obtain the florfenicol nano-crystal suspension Suspension.

[0032] (3) Spray drying: The florfenicol nanocrystal suspension prepared in step (2) is dried by a centrifugal spray dryer to obtain...

Embodiment 3

[0034] A preparation method of florfenicol nano crystals, comprising the following steps:

[0035] (1) Preparation of florfenicol nanosuspension: weigh 50 mg of florfenicol and dissolve in 20 mL of ethanol, dissolve SDS and hydroxypropyl methylcellulose in a ratio of 5:1 in 40 mL Prepare a stabilizer solution with a concentration of 5 mg / mL in deionized water, and slowly drop the florfenicol ethanol solution into the stabilizer solution under stirring conditions at room temperature; after dropping, transfer the suspension to a round bottom flask , Remove ethanol by rotary evaporation under reduced pressure at 40°C; the florfenicol nanosuspension can be prepared.

[0036] (2) Media grinding method: pour the florfenicol nanosuspension prepared in step (1) into the DYNO-MillResearch Lab media grinding machine [Huaerbao Machinery (Shenzhen) Co., Ltd.], add 0.1mm oxide 850 g of zirconium beads were ground for 15 min at 5° C. at a speed of 2000 r / min; the florfenicol nano-crystal s...

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Abstract

The invention relates to the technical field of veterinary drugs and discloses a preparation method of florfenicol nanocrystals. The preparation method comprises the steps that florfenicol and a stabilizer are prepared into a florfenicol nanosuspension, then the suspension is subjected to treatment by an ultrasonication method or a medium grinding method, and spray drying is performed to obtain the florfenicol nanocrystals. The preparation method solves the problems of low solubility of drugs and low drug loading capacity, and also enhances the safety and effectiveness of the drugs. Development of high-efficiency nanocrystal veterinary drugs can reduce the dosage of antibiotics and improve the absorption and distribution conditions of the drugs in vivo, thereby greatly reducing drug residues, ensuring food safety and reducing environmental pollution. The preparation method is also applicable to preparation of other nanocrystals.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a preparation method of florfenicol nano crystals. Background technique [0002] In recent years, my country's animal husbandry has developed rapidly, which has led to the development of the veterinary drug industry. Veterinary drugs play a very important role in preventing and controlling animal diseases, increasing production efficiency, and improving the quality of animal products. With the wide application of antibacterial and antiparasitic drugs in veterinary clinics and animal husbandry production, the problems of cross-resistance and drug residues have become increasingly prominent. Especially the misuse or unreasonable application has caused the main pathogenic bacteria of livestock and poultry to develop resistance to many antibacterial drugs, even multi-drug resistance. The abuse of veterinary drugs can easily lead to the residue of harmful substances in a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C317/32C07C315/06C07D235/32B82Y40/00
CPCB82Y40/00C07C315/06C07C317/32C07D235/32
Inventor 吴芳高崇凯刘佳华郭波红陈钰杆李晓芳魏海涛易军吴纯富陈晓颖陈悦群罗勋方
Owner 广东润华药业有限公司
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