Aconite two-element medicine release recipe for relieving pain of advanced stomach and liver cancers

Abstract

The invention relates to a recipe for relieving pain of stomach and liver cancers. The recipe consists of radix aconiti kusenzoffii and radix aconiti agrestis according to a ratio of 1 to 1. The recipe has the advantages that the ethyl alcohol extraction and water decoction are used as extraction technologies, the extract is obtained, the common granule and sustained-release granule of aconite areprepared, and a two-element medicine release capsule combination capable of quickly releasing the medicine in the stomach and slowly releasing the medicine in intestines in a locating way is obtained; by establishing the recipe of a two-element medicine release system with quick medicine release effect and slow medicine release effect, the effective blood concentration of the medicine in the stomach and liver is improved and maintained, and the safe, quick-effect and long-effect pain relieving purpose is realized.

Description

technical field [0001] The patent of the present invention belongs to the field of medicine, and relates to a composition of aconitum binary drug-release formulation for late-stage analgesia of gastric liver cancer and the content of the combination of binary drug-release preparations. [0002] On the basis of Aconitum injection, combined with the pharmacodynamic tests of analgesia, tumor cell inhibition and immunity, the patent of the present invention adopts a reasonable and feasible method of ethanol extraction and water decoction, thus obtaining a drug for oral administration rather than injection Based on the pharmacodynamic material basis of the Pain Relief Prescription for Advanced Stomach and Liver Cancer, the contents of the dual-release capsules are obtained with more precise curative effect, reduced dosage, controllable and stable quality, and combination of immediate release and sustained release. The dual-release drug capsules, through the organic combination of o...

AI Technical Summary

Problems solved by technology

In clinical practice, doctors mostly choose anti-cancer pain drugs according to the "three-step pain relief" scheme, that is, for mild pain, non-steroidal analgesics such as aspirin and ibuprofen are mostly used clinically. The mechanism of their analgesic effect By blocking the synthesis of prostaglandins, but it has a dose limit, its analgesic efficacy will not increase with the increase of the dosage, and side effects may occur; for moderate pain, codeine and cloth hydrochloride are often used clinically Weak opioid analgesics such as cinnamon injection have significantly better curative effect than the former, have a slight inhibitory effect on the human respiratory center, and tend to make people feel euphoric and less addictive after taking it; , strong opioid analgesics such as morphine, doperidine and methadone are commonly used clinically. These drugs only act on the central nervous system, and their strong analgesic effect comes from blocking and limiting the transmission of pain signals to a large extent and to a large extent. But addictive and side effects

In the advanced stage of cancer, strong opioids are often used clinically to suppress pain, including oxycodone hydrochloride sustained-release tablets, morphine hydrochloride (sustained-release) tablets, morphine sulfate sustained-release tablets, morphine hydrochloride injection, and fentanyl transdermal patches Drugs, etc. For patients with severe cancer pain, it is often necessary to increase the dose and frequency of analgesic drugs, and repeated use is prone to tolerance and addiction.