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Application of reduced glutathione in preparation of medicine for treating type 1 diabetes

A type 1 diabetes, glutathione technology, applied in drug combinations, tripeptide components, metabolic diseases, etc., can solve the problems of difficult to confirm the curative effect and difficult to promote, achieve stable disease, retain insulin secretion function, and control blood sugar. Effect

Inactive Publication Date: 2018-10-19
宋明强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In short, the curative effect is difficult to be sure, and naturally it is difficult to promote

Method used

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  • Application of reduced glutathione in preparation of medicine for treating type 1 diabetes
  • Application of reduced glutathione in preparation of medicine for treating type 1 diabetes
  • Application of reduced glutathione in preparation of medicine for treating type 1 diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1. The application of reduced glutathione in the preparation of drugs for the treatment of adult type 1 diabetes.

[0031] Case selection conditions:

[0032] Aged over 20 years old, meeting any one of the following items ① and ②, plus item 3.

[0033] ①Acute onset, hyperglycemia syndrome (thirst, polydipsia and polyuria, rapid weight loss, etc.) is prominent, and some patients show symptoms of ketoacidosis such as dehydration, circulatory failure, or coma. Islet-associated antibody positive or negative;

[0034] ② Absolutely need insulin therapy;

[0035] ③The course of disease of the enrolled cases was ≤6 months;

[0036] Pre-treatment preparation, start time, and inter-treatment evaluation methods

[0037] After diabetic ketosis or acidosis is corrected, blood sugar and condition control are stable, give OGTT glucose load test (adult 75g, child 50g), check 5 time points (before taking glucose and 30, 60, 120, 180 minutes after taking glucose) Or blood gl...

Embodiment 2

[0051] Example 2 The application of reduced glutathione in the preparation of drugs for treating children with type 1 diabetes.

[0052] The discovery of glutathione in the treatment of type 1 diabetes is of more supreme significance than its manifestation in children with type 1 diabetes. Children with type 1 diabetes need long-term insulin injections 3-4 times a day or continuous pump therapy. , School study and life have brought great inconvenience and trauma. The contradiction between the need to ensure nutrition for growing children and the need for strict diet control for diabetes often leads to frequent hypoglycemia and hyperglycemia in sick children, and such frequent blood sugar fluctuations can lead to complications of blood vessels, nerves and organs in diabetes of premature formation.

[0053] For this reason, in early 2018, we received 3 consecutive children with type 1 diabetes who were admitted to hospital due to sudden diabetic ketoacidosis. After their ketos...

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Abstract

The invention relates to application of reduced glutathione in preparation of a medicine for treating type 1 diabetes, and belongs to the technical field of medicine application. The technical schemeof the invention is application of the reduced glutathione in preparation of the medicine for treating the type 1 diabetes. The reduced glutathione provided by the invention can be clinically used ina form of injection, and is prepared by adopting a preparation method of an existing conventional injection. According to the application of reduced glutathione in the preparation of the medicine fortreating the type 1 diabetes, new use of the glutathione is found, and breakthrough for treating type 1 diabetes patients is realized for nearly one century.

Description

technical field [0001] The invention relates to the application of reduced glutathione in the preparation of medicines for treating type 1 diabetes, and belongs to the technical field of medicine application. Background technique [0002] Glutathione (Glutathione) widely exists in animals, plants and microorganisms. It is one of the most important non-protein sulfhydryl compounds in organisms. It has reduced glutathione (GSH) and oxidized glutathione (GSSG). GSH exists in large quantities in organisms and plays a major role. GSH is widely used in the treatment of liver diseases, tumors, oxygen poisoning, aging and endocrine diseases, and is used in the field of food as a biologically active additive and antioxidant. [0003] The clinical application of reduced glutathione injection mainly includes: liver and kidney damage; radiation and chemotherapy protection for tumor patients; diabetic complications, such as neuropathy; ischemic hypoxic encephalopathy and various hypoxem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61K38/28A61P3/10
CPCA61K38/063A61K38/28A61P3/10A61K2300/00
Inventor 宋明强贾伟平田海晔
Owner 宋明强
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