The invention provides a preparation method of compound glycyrrhizin tablets. The preparationraw materials includes, by weight,10-15parts of monoammonium glycyrrhizanate (calculated byglycyrrhizin), 10-15parts ofglycine, 10-15parts ofDL-methionine, 5-20parts ofdisintegrating agent, 0.2-5 parts ofadhesive, 0.2-5 parts of lubricant, 0.2-5 parts of flow aid, 5-40 parts ofthinner,and 0.5-5parts ofcoating powder.The preparation method includes the steps of powder sieving, premixing, dry-process granulation, whole mixing, intermediate content detection, tableting and coating.The inventionfurther provides a quality control detection method.Ahigh performance liquid chromatography method based on a non-derivative method is adopted to directly determine the glycine and DL-Methionine content, related substances and dissolution. The process steps are simple, the production cost is low, the detection method is rapid, accurate and reliable, facilitates improvement of the stability of the tablets and improves product quality.