Markers for nasopharyngeal carcinoma diagnosis

Abstract

The invention discloses markers for nasopharyngeal carcinoma diagnosis. The group of markers comprise TCRBV5.4, TCRBV6.3, TCRBV6.4, TCRBV6.6, TCRBV6.7, TCRBV7.9, TCRBV8.1, TCRBV10.2, TCRBV10.3, TCRBV12.3, TCRBV12.4, TCRBV15, TCRBV20.1, TCRBV22 and TCRBV25.1, and a nasopharyngeal carcinoma diagnosis formula is constructed through an LASSO model, so that a method for predicting nasopharyngeal carcinoma is obtained according to the TCR genes; through ROC detection, when an AUC value of the diagnosis formula in a test group reaches 0.96, and the sensitivity is 0.95, the specificity is 0.86; when the AUC value is 0.74 in a verification group, and the sensitivity is 0.79, the specificity is 0.75, and the diagnosis performance is good.

Description

technical field [0001] The invention relates to a marker for nasopharyngeal carcinoma diagnosis. Background technique [0002] Nasopharyngeal carcinoma, also known as "Guangdong tumor", has been proposed for more than 140 years. 80% of nasopharyngeal cancer cases in the world occur in China, especially in provinces such as Guangdong in southern China. Nasopharyngeal carcinoma is currently a disease with a high cure rate, and the key lies in early diagnosis and timely treatment. Therefore, the screening and diagnosis of nasopharyngeal carcinoma is particularly important. However, due to the hidden anatomical location of the nasopharynx, the early symptoms of nasopharyngeal carcinoma are not obvious, which brings certain difficulties to the early diagnosis of nasopharyngeal carcinoma. [0003] At present, the main auxiliary examination methods for nasopharyngeal carcinoma include electronic nasopharyngoscopy, nasopharyngeal CT and serological examination of EB virus. The e...

AI Technical Summary

Problems solved by technology

The electronic nasopharyngoscope has strong illumination and clear images, and can dynamically observe the whole picture of the nasopharynx, and can find tiny hidden lesions in the nasopharynx. However, because the electronic nasopharyngoscope cannot find submucosal lesions, there are also some false negatives

CT image resolution is very high, it is more economical and practical, and the skill can distinguish bone and soft tissue. The equipment is relatively popular, and it is a commonly used method in the diagnosis of nasopharyngeal carcinoma. Early lesions with small volume in hidden parts are often difficult to find, especially in isodense lesions. At the same time, local verification, secretions and lymphoid tissue make it difficult to judge the symmetry of nasopharyngeal carcinoma on CT.

Studies have shown that Epstein-Barr virus is closely related to the occurrence and development of nasopharyngeal carcinoma. Epstein-Barr virus serological examination, as an auxiliary indicator for the diagnosis of nasopharyngeal carcinoma, has certain guiding significance in nasopharyngeal carcinoma, but there are certain false positives in this method, not only Increased clinical workload and brought unnecessary pressure to the subjects

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