A method for establishing a diagnostic model of acute myeloid leukemia and its application

A technology for acute myeloid cells and diagnostic models, applied in the field of establishing diagnostic models of acute myeloid leukemia, can solve the problems of lack of circulating cells, patient invasiveness, missed diagnosis, misdiagnosis, etc., to improve accuracy and atopy, avoid aggressive effect
CN109633142BActive Publication Date: 2021-08-27FOURTH MILITARY MEDICAL UNIVERSITY
19 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FOURTH MILITARY MEDICAL UNIVERSITY
Publication Date
2021-08-27

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a method for establishing a diagnostic model of acute myeloid leukemia. The method comprises: 1. collecting serum; 2. analyzing and detecting the serum by ultra-high performance liquid chromatography and mass spectrometry; Serum spectra of patients and healthy controls to determine biomarkers; 4. Confirm the chemical information of biomarkers; 5. Confirm that glutamic acid, kynurenine, and oleic acid are the optimal biomarkers and establish a diagnostic model; The invention also discloses an application method of a diagnostic model of acute myeloid leukemia, in which the serum of a subject is brought into the diagnostic model of acute myeloid leukemia, and whether the subject is ill is judged through calculation. The diagnostic model obtained by the present invention is accurate and efficient, and avoids invasiveness to patients; the application method of the present invention is simple and easy to obtain, has high sensitivity, can non-invasively, efficiently and accurately distinguish acute myeloid leukemia patients from healthy persons, and is suitable for popularization use.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a method for establishing a diagnosis model of acute myeloid leukemia and its application. Background technique

[0002] Acute myeloid leukemia (also known as acute myeloid leukemia or acute myeloid leukemia) is a hematological malignancy characterized by abnormal proliferation and differentiation of bone marrow cells, and it is also the main pathological type of adult acute leukemia (accounting for about 80% -90%), the clinical manifestations are complicated, most of the cases are acute and severe, and the prognosis is dangerous, if not treated in time, it can often be life-threatening. At present, the diagnosis of acute myeloid leukemia mainly relies on peripheral blood cell examination and bone marrow biopsy, both of which have certain limitations. A major limitation of peripheral blood cell testing is that many patients do not have detectable circulating cell...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More