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Composition for substituting fructus xanthii to prepare glioma treatment medicine and measuring method

A technology for glioma and therapeutic drug, which is applied in the field of composition for preparing glioma therapeutic drug by replacing Xanthium japonica and the field of determination thereof

Inactive Publication Date: 2018-10-30
杨真慧
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, it is not known which combination of these ingredients can basically replace the medicinal effect of Xanthium

Method used

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  • Composition for substituting fructus xanthii to prepare glioma treatment medicine and measuring method
  • Composition for substituting fructus xanthii to prepare glioma treatment medicine and measuring method
  • Composition for substituting fructus xanthii to prepare glioma treatment medicine and measuring method

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Effect test

Embodiment Construction

[0046] The substantive content of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, but the protection scope of the present invention is not limited thereto.

[0047] 1. Experimental materials

[0048] The cocklebur medicinal material was purchased from Bozhou medicinal material market, and its origin was Benxi, Liaoning. After being pulverized, it was dried at 55°C overnight, and dried and stored for later use.

[0049] Agilent 1100 liquid chromatograph; Sartorius BS210S electronic balance, Beijing Sartorius Instrument System Co., Ltd.; Sartorius CP225D electronic balance, Beijing Sartorius Instrument System Co., Ltd.; acetonitrile (chromatographically pure) and methanol (chromatographically pure) were purchased from TEDIA; the water is Wahaha purified water.

[0050] RNAiso plus reagent, SYBRGreen PCRMaster Mix and PrimeScript RT kit were purchased from TaKaRa.

[0051] 2. Experimental method

[0052] 1....

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Abstract

The invention discloses a composition for substituting fructus xanthii to prepare a glioma treatment medicine and a measuring method. The composition composed of neochlorogenic acid, chlorogenic acid,xanthiside, 1,5-dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid basically can substitute an inhibitory effect of the fructus xanthii on mTOR gene expression equivalently, wherein the compositionand the fructus xanthii have equivalent strength; the composition can be used for equivalently substituting the fructus xanthii to prepare an mTOR gene expression inhibitor. Those skilled in the art know that inhibition of the mTOR gene expression can effectively inhibit proliferation of glioma cells (miRNA-99b negatively regulates ability of mTOR for inhibiting invasion of glioma cells. Chinese Pharmacological Bulletin, April 2018, Vol. 34, No. 4); therefore, the composition can be used for equivalent substitution of the fructus xanthii to prepare the glioma treatment medicine.

Description

technical field [0001] The invention relates to a composition used to replace cocklebur seeds to prepare tumor therapeutic drugs and a determination method thereof. Background technique [0002] Fructus Xanthii (Fructus Xanthii) is the dry and mature fruit with seed coat of Xanthium sibiricum Patr. et Widd., which has the effects of dispelling wind and dehumidification, clearing the nose and resuscitation. Modern studies have shown that it has a therapeutic effect on tumors. [0003] The use of fruit as medicine has the disadvantages of complex components, unclear medicinal components, and difficult quality control. If a composition that can replace the Xanthium as medicine can be found, the chemically blended product can be used instead of the Xanthium as medicine, and the composition is clear and the quality is controllable. [0004] Xanthium mainly contains neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, thiazidediketone glycoside, 1,5-dicaffeoylquinic ac...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K31/706A61P35/00G01N30/02
CPCA61K31/216A61K31/706G01N30/02A61K2300/00
Inventor 杨真慧
Owner 杨真慧
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