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Tripteryne or tripteryne derivative vesicle and preparation method thereof

A technology of tripterycin and vesicles, which is applied in the field of medicine, can solve the problems of limiting the clinical application of tripteryne, low bioavailability, poor solubility, etc., to reduce toxicity and adverse reactions, simple use, The effect of enhancing medication adherence

Active Publication Date: 2020-12-15
UNIVERSITY OF MACAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tripterygol is insoluble in water, with a LogP of 7.08. The poor solubility results in a low bioavailability in application, which limits the clinical application of tripteryne

Method used

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  • Tripteryne or tripteryne derivative vesicle and preparation method thereof
  • Tripteryne or tripteryne derivative vesicle and preparation method thereof
  • Tripteryne or tripteryne derivative vesicle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 4

[0082] Select embodiment 4 as test medicine

[0083]

Embodiment 1

[0091] Dissolve tripterine 4mg, Span 20 40mg, Span 60 20mg, and cholesterol 20mg in 5ml of chloroform, remove the organic solvent by rotary evaporation at 60°C, add 5ml of ultrapure water, hydrate at 60°C for 30 min, and use Probe No. 3 was subjected to probe ultrasound for 4 minutes to obtain a 5 ml solution of retorubin vesicles. Weigh 160mg of Carbomer 974 in 15ml of ultrapure water, stir and hydrate for 2 hours to fully hydrate, add 5ml of tripterine vesicle solution and stir evenly, then add a little diethanolamine aqueous solution to adjust the pH to 7, that is Tripterine vesicle preparations were obtained.

Embodiment 2

[0093] Dissolve tripterine 4mg, Span 40 40mg, Span 80 20mg, and cholesterol 20mg in 5ml of chloroform, remove the organic solvent by rotary evaporation at 60°C, add 5ml of ultrapure water, hydrate at 60°C for 30 min, and use Probe No. 3 was used for probe ultrasound for 2 minutes to obtain a 5 ml solution of rekorubin vesicles. Weigh 160mg of Carbomer 934 into 15ml of ultrapure water, stir and hydrate for 2 hours to fully hydrate, add 5ml of tripterine vesicle solution and stir evenly, then add a little diethanolamine aqueous solution to adjust the pH to neutral Obtain tripterine vesicle preparation.

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Abstract

The invention belongs to the technical field of medicine and relates to a vesicle containing a tripterine or a tripterine derivative. The vesicle is composed of the tripterine or the tripterine derivative, a nonionic surfactant, a stabilizer and ultrapure water. The vesicle has a good effect in treatment of psoriasis.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and in particular relates to a vesicle containing tripterine or tripterine derivatives, a preparation method of the vesicle, a vesicle preparation and a preparation method of the vesicle preparation. Background technique: [0002] Psoriasis is an immune-mediated chronic skin inflammation with an incidence of 1% to 3% of the world's population. Its course of disease is long, show effect repeatedly, bring serious physical and psychological injury to the patient. Among the six types of psoriasis, psoriasis vulgaris is the most common, accounting for about 90% of all psoriasis cases. Psoriasis vulgaris is characterized by excessive proliferation and differentiation of epidermal keratinocytes and inflammatory cell infiltration in the dermis. The main clinical manifestations are pruritus, erythema, desquamation and epidermal thickening. At present, the pathogenesis of psoriasis has not been fully e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K9/06A61K47/28A61K31/56A61P17/06
CPCA61K9/0014A61K9/06A61K9/127A61K31/56A61K47/28A61P17/06
Inventor 郑颖孟世康
Owner UNIVERSITY OF MACAU