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A kind of emodin molecularly imprinted silica nanoparticle composite film and its preparation method and application

A silicon dioxide and nanoparticle technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve the problems of low flow rate and low flow rate of molecularly imprinted membrane, and achieve difficult recovery, high flow rate, and smooth flow rate. high volume effect

Active Publication Date: 2020-11-03
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the technical defects existing in the prior art, solve the problems of small flow and low flow rate of traditional molecularly imprinted membranes, so that the separation efficiency of the target molecule emodin is greatly improved

Method used

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  • A kind of emodin molecularly imprinted silica nanoparticle composite film and its preparation method and application
  • A kind of emodin molecularly imprinted silica nanoparticle composite film and its preparation method and application
  • A kind of emodin molecularly imprinted silica nanoparticle composite film and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Preparation of tetraethyl orthosilicate modified cellulose acetate membrane:

[0044] Submerge 3 pieces of commercially available cellulose acetate membranes (47mm×0.135mm) into a mixed solution consisting of 100mL deionized water, 30mL ethanol and 1mL tetraethyl orthosilicate, shake for 5min, slowly add 0.5mL ammonia water dropwise, and ultrasonically Evenly, vibrate in an oscillator for 6 hours, seal, soak in deionized water, wash and dry to obtain a silica-modified cellulose acetate film; figure 1 As shown, the silica-modified cellulose acetate membrane was coated with a polymer layer of uniform thickness.

[0045] (2) Preparation of emodin molecularly imprinted silica nanoparticle composite film:

[0046] After ultrasonically mixing 0.1211g of Tris and 100mL of water, adjust the pH value to 8.5, and add 3 pieces of silica-modified cellulose acetate membrane obtained in the above step (1) to achieve the purpose of purification; Add the purified membrane to a mi...

Embodiment 2

[0050] (1) Preparation of tetraethyl orthosilicate modified cellulose acetate membrane

[0051] Submerge 3 pieces of commercially available cellulose acetate membranes (47mm×0.135mm) into a mixed solution consisting of 100mL deionized water, 30mL ethanol and 1mL tetraethyl orthosilicate, shake for 5min to complete the reaction, and slowly drop 0.5mL Ammonia, ultrasonically uniform, oscillating in an oscillator for 6 hours, sealing, washing with deionized water after soaking, and drying to obtain a silica-modified cellulose acetate membrane.

[0052] (2) Preparation of emodin molecularly imprinted silica nanoparticles composite film

[0053] After ultrasonically mixing 0.1211g of Tris and 100mL of water, adjust the pH value to 8.5, and add 3 pieces of silica-modified cellulose acetate membrane obtained in the above step (1) to achieve the purpose of purification; Add the purified membrane to a mixture of 0.025g emodin, 100mL water and 0.1211g trishydroxymethylaminomethane, ult...

Embodiment 3

[0057] (1) Preparation of tetraethyl orthosilicate modified cellulose acetate membrane

[0058] Submerge 3 pieces of commercially available cellulose acetate membranes (47mm×0.135mm) into a mixed solution consisting of 100mL deionized water, 30mL ethanol and 1mL tetraethyl orthosilicate, shake for 5min, slowly add 0.5mL ammonia water dropwise, and ultrasonically Evenly, oscillate in an oscillator for 6 hours, seal, wash with deionized water after soaking, and dry to obtain a silica-modified cellulose acetate film;

[0059] (2) Preparation of emodin molecularly imprinted silica nanoparticles composite film

[0060] After ultrasonically mixing 0.1211g of Tris and 100mL of water, adjust the pH value to 8.5, and add 3 pieces of silica-modified cellulose acetate membrane obtained in the above step (1) to achieve the purpose of purification; Add the purified membrane to a mixture composed of 0.1g emodin, 100mL water and 0.1211g trishydroxymethylaminomethane, ultrasonically uniform,...

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Abstract

The invention belongs to the technical field of preparation of functional materials and particularly relates to a rheum emodin molecularly imprinted silica nanoparticle composite membrane as well as apreparation method and application thereof, specifically a molecularly imprinted composite film based on rheum emodin serving as a template molecule prepared by taking a cellulose acetate membrane asa basement membrane, taking the rheum emodin as the template molecule, taking dopamine as a functional monomer and a cross-linking agent and combining a nanoparticle surface modification technology and a molecularly imprinted polymer technology. The rheum emodin molecularly imprinted silica nanoparticle composite membrane prepared according to the preparation method disclosed in the invention hashigh specific recognition capacity and adsorption separation capacity, and the preparation method has the characteristics of being safe, non-toxic, low in energy consumption and easy to operate; thecomposite membrane can be applied to selective adsorption in analogues of rheum emodin and separation of the rheum emodin.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional materials, and in particular relates to an emodin molecularly imprinted silicon dioxide nanoparticle composite film and a preparation method and application thereof. Background technique [0002] Emodin is an active ingredient in herbal medicine derived from anthraquinone compounds. It exhibits a variety of pharmacological activities and can be used as a laxative, antipyretic, tonic, anticancer and antiviral drug, etc. With the increasing application of emodin in medical treatment, the demand for high-purity emodin increases, so there is an urgent need for effective methods to separate emodin from its analogs. In the past few decades, it is generally separated by capillary electrophoresis with amperometric detection and high-performance thin-layer chromatography; however, these methods have the disadvantages of poor affinity and insufficient selectivity, and the separation metho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D69/12B01D71/62B01D67/00C08G73/06
CPCB01D67/0079B01D69/12B01D71/62C08G73/0672
Inventor 于超卢健吴易霖闫永胜李春香
Owner JIANGSU UNIV
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