Emodin molecular imprinted titanium dioxide nanoparticle composite film and preparation method and application thereof

A titanium dioxide, molecular imprinting technology, applied in chemical instruments and methods, alkali metal compounds, alkali metal oxides/hydroxides, etc., can solve the problems of low flow rate and low flow rate of molecular imprinted membranes, and achieve difficult recovery and flow rate. Large, high-throughput effects

Active Publication Date: 2018-11-16
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the technical defects existing in the prior art, solve the problems of small flow and low flow rate of traditional molecularly imprinted membranes, so that the separation efficiency of the target molecule emodin is greatly improved

Method used

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  • Emodin molecular imprinted titanium dioxide nanoparticle composite film and preparation method and application thereof
  • Emodin molecular imprinted titanium dioxide nanoparticle composite film and preparation method and application thereof
  • Emodin molecular imprinted titanium dioxide nanoparticle composite film and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] (1) Preparation of titanium dioxide modified cellulose acetate membrane

[0050] Add 0.03moL of boric acid and 1.8549g of ammonium fluotitanate to 100mL of deionized water, ultrasonically homogenize, adjust the pH value to 3.86 after hydrolysis for 1 hour, add purified cellulose acetate membrane, seal and vibrate in a shaker for 2 hours, soak with deionized After washing with water and drying at 40°C, a titanium dioxide-modified cellulose acetate film was obtained; figure 1 , figure 2 It can be observed that the purified cellulose acetate membrane after titanium dioxide modification is coated with a polymer layer of uniform thickness.

[0051] (2) Preparation of emodin molecularly imprinted titanium dioxide nanoparticle composite film

[0052] After ultrasonically mixing the mixture of 0.1211g tris and 100mL water, adjust the pH value to 8.5, and add 3 pieces of titanium dioxide-modified cellulose acetate membrane obtained in the above step (1) to achieve the purpose...

Embodiment 2

[0056] (1) Preparation of titanium dioxide modified cellulose acetate membrane

[0057] Add 0.03moL boric acid and 1.8549g ammonium fluotitanate to 100mL deionized water, ultrasonically homogenize, hydrolyze for 0.5h, adjust the pH value to 3.86, add purified cellulose acetate membrane, vibrate in a shaker for 1h, seal, and use after soaking After cleaning with deionized water and drying, titanium dioxide modified cellulose acetate film is obtained;

[0058] (2) Preparation of emodin molecularly imprinted titanium dioxide nanoparticle composite film

[0059] After ultrasonically mixing the mixed solution of 0.1211g of trishydroxymethylaminomethane and water, adjust the pH value to 8.5, and add 3 pieces of titanium dioxide-modified cellulose acetate membranes obtained in the above step (1) to achieve the purpose of purification; Add the purified titanium dioxide-modified cellulose acetate membrane to an aqueous solution composed of 0.025g emodin, 100mL water and 0.1211g trishy...

Embodiment 3

[0064] (1) Preparation of titanium dioxide modified cellulose acetate membrane

[0065] Add 0.03moL boric acid and 1.8549g ammonium fluotitanate to 100mL deionized water, ultrasonically homogenize, hydrolyze for 2 hours, adjust the pH value to 3.86, add purified cellulose acetate membrane, vibrate in a shaker for 1 hour, seal it, and use it after soaking After washing with deionized water and drying, titanium dioxide modified cellulose acetate film is obtained;

[0066] (2) Preparation of emodin molecularly imprinted titanium dioxide nanoparticle composite film

[0067] After ultrasonically mixing the mixture of 0.1211g of Tris and water, adjust the pH value to 8.5, add 3 pieces of TiO obtained in the above step (1) 2 Modified cellulose acetate membrane to achieve the purpose of purification; the purified TiO 2 Add the modified cellulose acetate membrane to an aqueous solution composed of 0.1g emodin, 100mL water and 0.1211g trishydroxymethylaminomethane, ultrasonically unif...

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Abstract

The invention belongs to the technical field of functional material preparation, and specifically relates to an emodin molecular imprinted titanium dioxide nanoparticle composite film and a preparation method and application thereof. The emodin molecular imprinted titanium dioxide nanoparticle composite film is prepared by taking a cellulose acetate membrane as a basement membrane, emodin as template molecules, dopamine as a functional monomer and a crosslinking agent and combining a nanoparticle surface modification technology and a molecular imprinting polymerization technology. The emodin molecular imprinted titanium dioxide nanoparticle composite membrane prepared by the method has high specific recognition ability and adsorption and separation ability to emodin, and the preparation method is safe, non-toxic, low in energy consumption and easy in operation. The composite membrane can be applied to the selective adsorption and separation of emodin in emodin analogs.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional materials, and in particular relates to an emodin molecularly imprinted titanium dioxide nanoparticle composite film, a preparation method and application thereof. Background technique [0002] Emodin is an active ingredient in herbal medicine derived from anthraquinone compounds. It exhibits a variety of pharmacological activities and can be used as a laxative, antipyretic, tonic, anticancer and antiviral drug, etc. With the increasing application of emodin in medical treatment, the demand for high-purity emodin is increasing, so there is an urgent need for an effective method to separate emodin from its analogues. In the past few decades, it is generally separated by capillary electrophoresis with amperometric detection and high-performance thin-layer chromatography; however, these methods have the disadvantages of poor affinity and insufficient selectivity, and the separation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/12B01D69/02B01D71/10B01D67/00B01J20/26B01J20/28B01J20/30C08J9/26C08G73/06C08J5/18C08L1/12C08K3/22
CPCB01D67/0093B01D69/02B01D69/125B01D71/10B01D2325/10B01J20/268B01J20/28033C08G73/0672C08J5/18C08J9/26C08J2301/12C08K2003/2241C08K2201/011
Inventor 于超卢健吴易霖闫永胜李春香
Owner JIANGSU UNIV
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