A kind of water-soluble fluorescent silicon dot and its preparation method and application

Abstract

The invention relates to a water-soluble fluorescent silicon point as well as a preparation method and an application thereof. The water-soluble fluorescent silicon point is synthesized from (3-aminopropyl) trimethoxy silane as a precursor and ferulic acid as a reducer by a hydrothermal reaction. The fluorescent silicon point can be applied to detection of rutin content and identification of rutinand quercetin. The fluorescent silicon point has the advantages of being stable in performance, green and environmentally friendly, and the preparation method is simple. The fluorescent silicon pointas a spectral signal probe can realize rutin detection in a serum system or a phosphate buffer system containing a small amount of BSA, and other common traditional Chinese medicine active substancesincluding quercetin have no obvious interference effect on a detection result. The detection method has the advantages of being fast, simple, good in detection sensitivity, high in selectivity and the like, defects of poor sensitivity, high interference, complicated pretreatment or expensive instruments of a conventional detection method are overcome, and the detection method is a simple and practical pharmaceutical analysis and quantification technology.

Description

technical field [0001] The invention relates to the field of analysis and detection, in particular to a water-soluble fluorescent silicon dot and its preparation method and application. Background technique [0002] As a representative zero-dimensional silicon nanomaterial, fluorescent silicon dots have great prospects in life analysis and food and drug detection applications due to their good fluorescence stability, excellent biocompatibility and low toxicity. However, fluorescent silicon dots usually have poor water dispersibility due to the surface-covered hydrophobic functional groups. Some methods for synthesizing water-soluble fluorescent silicon dots (SiNCs) have been reported in recent years, but these methods usually require at least two independent steps: first, large-scale Si-based materials are used as Si sources (e.g., crystalline Si particles, SiOx powder or SiNCs). nanowires, etc.) to prepare hydrophobic silicon dots; after that, the hydrophobic silicon dots ...

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Problems solved by technology

However, flavonoids are very similar in spectral behavior. Generally, it is difficult to distinguish and quantify rutin from other flavonoids by spectral methods. In particular, there is only one glycoside difference between quercetin and rutin in structure. The properties are very close, and it is very difficult to distinguish and quantify the two with conventional spectral methods

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