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Combined medicine for treating leukemia, and application of combined medicine

A leukemia and drug technology, applied in the field of combined drugs for the treatment of leukemia, to improve compliance, prolong survival, and reduce serious adverse reactions

Inactive Publication Date: 2018-11-23
SICHUAN CREDIT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on its use in the treatment of leukemia

Method used

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  • Combined medicine for treating leukemia, and application of combined medicine
  • Combined medicine for treating leukemia, and application of combined medicine
  • Combined medicine for treating leukemia, and application of combined medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 tablet

[0031]

[0032] Sieve the raw and auxiliary materials separately; put the prescribed amount of busulfan, tandospirone citrate and low-substituted hydroxypropyl methylcellulose in a mixer, mix evenly, then add mannitol, lactose starch in turn, and finally add Sweet orange essence and magnesium stearate are mixed evenly; the powder is directly compressed into tablets.

Embodiment 2

[0033] The preparation of embodiment 2 capsules

[0034]

[0035] Busulfan, tandospirone oxalate and starch are uniformly mixed by an equal-volume increasing method, then mixed with microcrystalline cellulose, granulated, and packed into capsules to obtain capsules.

Embodiment 3

[0036] The preparation of embodiment 3 injection

[0037]

[0038] The inert gas is charged into polyethylene glycol 400 as a pharmaceutical solvent to make it saturated; L-tandospirone tartrate and busulfan are dissolved in N,N-dimethylacetamide, and the obtained solution and the obtained drug Mix evenly with the solvent polyethylene glycol 400 to obtain the final mixed medicinal solution; filter and sterilize, fill, melt seal, and the product is ready.

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PUM

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Abstract

The invention relates to a combined medicine for treating leukemia, and application of the combined medicine. The combined medicine is prepared from 5-HT1A receptor agonist and busulfan. The combinedmedicine has a remarkable treatment effect in treatment of the leukemia, especially treatment of chronic myelogenous leukemia; compared with the singly used busulfan, the combined medicine is better in treatment effect; the combined medicine has a synergistic effect.

Description

technical field [0001] The invention relates to a combination drug for treating leukemia and its application. Background technique [0002] Leukemia is a hematopoietic tumor disease, chronic myeloid leukemia is a kind of leukemia, and its incidence rate is 18.6% (about 1 / 5) of leukemia. Chronic myeloid leukemia is a malignant tumor that seriously affects the blood and bone marrow. It is characterized by the accumulation of a large number of immature white blood cells in the bone marrow, inhibiting the normal hematopoiesis of the bone marrow, and spreading to the whole body through the blood, resulting in anemia, bleeding, and infection in patients. and organ infiltration. [0003] Busulfan, the chemical name is 1,4-butanediol dimesylate, and its structure is: [0004] [0005] A bifunctional alkylating agent belonging to the bis-methylsulfonate class, which is a non-specific drug for the cell cycle, enters the human body to open the ring structure of the sulfonate group...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/506A61K31/427A61K31/255A61P35/02
CPCA61K31/255A61K31/427A61K31/506A61K45/06A61K2300/00
Inventor 于艺梅李晓莉陈刚陶建林鲍文娟
Owner SICHUAN CREDIT PHARMA
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