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Method for measuring TMS movement threshold in mouse waking state

A wake-up state, motion threshold technology, applied in diagnostic recording/measurement, medical science, sensors, etc., can solve the problems of large differences in the maximum output of magnetic stimulators, lack of individuality, and difficult comparison of research results, etc., to achieve accurate Setting the Effect of TMS Stimulation Intensity

Active Publication Date: 2018-11-30
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0003] In the current TMS rat research, some use the percentage of the maximum output of the magnetic stimulator as the TMS stimulation intensity, which lacks individuality, and the maximum output of different magnetic stimulators varies greatly, which makes it difficult to compare the results of different studies

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  • Method for measuring TMS movement threshold in mouse waking state
  • Method for measuring TMS movement threshold in mouse waking state

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Embodiment Construction

[0028] A method for measuring the TMS motor threshold in rats in an awake state of the present invention will be described in detail below with reference to the embodiments and accompanying drawings.

[0029] A method for measuring the TMS motor threshold in rats in an awake state of the present invention, first adopts the mode of inhalation gas anesthesia to temporarily anesthetize the rats; secondly, the rats are restrained and fixed on the bracket by self-adhesive bandages, and the height of the bracket is greater than The length of the rat limbs (including forelimbs and hindlimbs), the rat limbs are suspended in the air and kept in a relaxed state; then the hair is shaved around the target muscle, and the surface electromyography measurement electrode and the ground electrode are respectively pasted on the target muscle and tail of the rat limb ; Finally, the TMS pulse is applied to the motor cortex of the rat, and the measurement of the TMS movement threshold of the rat in...

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Abstract

The invention discloses a method for measuring a TMS movement threshold in a mouse waking state. The method comprises the following steps: performing 2-3 minutes of anesthesia on a mouse by using a suction-type gaseous anesthesia mode; placing the anesthetic mouse on a bracket, and constraining and fixing the mouse on the bracket through a self-adhering bandage, wherein a height of the bracket isgreater than a length of front and rear limbs of the mouse, enabling the limbs of the mouse to be suspended and keeping a relaxing state; barbering around a target muscle of the limbs of the mouse, exposing a muscle belly and a muscle tendon of the target muscle, and pasting a surface myoelectricity measuring electrode and a grounding electrode; in the waking state of the mouse, enabling a TMS pulse to act on a mouse movement cortex, through observing mouse limb movement or through analyzing a movement evoked potential in a surface electromyogram signal at the target muscle, completing measurement of the TMS movement threshold in the mouse waking state. The method is capable of measuring the TMS movement threshold in the mouse waking state. The TMS movement threshold in the waking state ismore helpful to accurately set TMS stimulus intensity in a mouse TMS experiment compared with the TMS movement threshold in an anesthetic state.

Description

technical field [0001] The invention relates to a method for measuring the TMS motor threshold of rats. In particular, it relates to a method for measuring TMS motor threshold in awake rats. Background technique [0002] Transcranial magnetic stimulation (TMS) technology is a technology that uses time-varying pulsed magnetic fields to act on the central nervous system (mainly the brain), changing the membrane potential of cortical nerve cells, causing them to generate induced currents, and affecting brain metabolism. And nerve electrical activity, thereby triggering a series of physiological and biochemical responses of magnetic stimulation technology. TMS mainly has four stimulation parameters: intensity, frequency, string stimulation time, and interval between strings. Among them, the TMS stimulation intensity refers to the magnetic induction intensity generated on the surface of the stimulation coil during operation, which represents the stimulation energy given by the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0488A61B5/00
CPCA61B5/4827A61B5/389
Inventor 殷涛王欣刘志朋王腾飞
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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