Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation of polymer drug-loaded particle device by an improved supercritical antisolvent method

A supercritical anti-solvent and polymer technology, which is applied in the direction of coating particles, granulating raw materials, chemical instruments and methods, etc., can solve the problems of inability to achieve high-efficiency packaging of materials

Active Publication Date: 2021-03-09
SOUTHEAST UNIV
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the problem that the existing supercritical anti-solvent method for preparing polymer drug-loaded particles cannot achieve efficient encapsulation of substances easily soluble in supercritical fluids, the present invention provides an improved supercritical anti-solvent method for preparing polymer drug-loaded particles. , the device is coupled with supercritical fluid anti-solvent technology and supercritical fluid impregnation technology, and can efficiently load substances with different solubility properties in supercritical fluid into polymer particles. To achieve this purpose, the present invention provides an improved A polymer drug-loaded particle device prepared by a supercritical antisolvent method, including a supercritical fluid supply branch, a solution supply branch, a supercritical fluid impregnation branch, a pressure control system and a granulation system, the supercritical fluid supply branch is The supercritical fluid storage tank, the third valve, the cooling tank, the fourth valve, the second high-pressure delivery pump and the second flow control meter are connected in sequence through pipelines, and the granulation system is a granulation tank connected in sequence through pipelines, the first Eight valves, a solvent recovery tank, an eleventh valve and a third flow control meter, the second flow control meter of the supercritical fluid supply branch is connected with the granulation tank of the granulation system through the sixth valve, and the solution supply The branch is connected in turn by the solution storage tank, the first valve, the first high-pressure delivery pump, the first flow control meter and the second valve, and then connected to the granulation tank through pipelines; Connect the seventh valve, the medicine tank, and the fifth valve to the inlet of the second high-pressure delivery pump; the pressure control system is sequentially connected to the nitrogen storage tank and the twelfth valve and then connected to the second high-pressure delivery pump through pipelines. The drug tank and the granulation tank are connected with a pressure relief valve

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation of polymer drug-loaded particle device by an improved supercritical antisolvent method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Such as figure 1 As shown, first close all valves of the device, add the ethanol solution dissolved with polylactic acid and paclitaxel into the solution storage tank 2, start the temperature control devices of the solution storage tank 2, cooling tank 4, and granulation tank 6 to reach the set temperature Finally, open the third valve V3, the fourth valve V4, and the sixth valve V6, open the second high-pressure delivery pump B2, inject carbon dioxide into the granulation tank 6, and open the first valve V1 and the second valve after reaching the predetermined temperature and pressure. Two valve V2, open the first high-pressure delivery pump B1, make the solution in the solution storage tank 2 enter the granulation tank 6 at a certain flow rate through the first flow control meter, open the ninth valve V9 and the eleventh valve V11 at the same time, use Supercritical carbon dioxide acts as an anti-solvent to produce granules; after granulation is completed, close the f...

Embodiment 2

[0023] Such as figure 1 As shown, first close all the valves of the device, add Adefovir (Adefovir) into the drug tank 5, and dissolve the polylactic acid-polyglycolic acid copolymer and the iron oxide nanoparticles treated with oleic acid in dichloromethane Put the solution into the solution storage tank 2, start the temperature control devices of the solution storage tank 2, the cooling tank 4, and the granulation tank 6, and open the third valve V3, the fourth valve V4, and the sixth valve V6 after reaching the set temperature, and open the first The second high-pressure delivery pump B2 injects carbon dioxide into the granulation tank 6. After reaching the predetermined temperature and pressure, open the first valve V1 and the second valve V2, turn on the first high-pressure delivery pump B1, and use the first flow control meter to make the The solution in the solution storage tank 2 enters the granulation tank 6 at a certain flow rate, and the ninth valve V9 and the eleve...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an improved supercritical anti-solvent method for preparing polymer drug-loaded particles, which includes a supercritical fluid supply branch, a solution supply branch, a supercritical fluid impregnation branch, a pressure control system and a granulation system. The invented device can prepare polymer drug-loaded particles by supercritical anti-solvent method by combining the solution containing polymer and drug with supercritical fluid in a granulation tank for drugs that are difficult to dissolve in supercritical fluid; for drugs that are easily soluble in supercritical fluid For fluid drugs, polymer particles can be prepared by anti-solvent method, and polymer drug-loaded particles can be prepared by supercritical impregnation technology. The device of the invention realizes the coupling of the supercritical solution impregnation system and the supercritical anti-solvent system, and can realize high-efficiency loading of drugs with various solubility properties in the supercritical fluid in the polymer particles.

Description

technical field [0001] The present invention relates to the technical field of preparation of polymer drug-loaded particles by supercritical fluid anti-solvent method, in particular to an improved supercritical anti-solvent method for preparing polymer drug-loaded particles. Background technique [0002] In the field of food and drug preparations, supercritical fluids, especially supercritical carbon dioxide, have great practical advantages due to their low critical temperature and critical pressure. Corrosiveness, no residue and other characteristics make it a green substitute for traditional organic solvents, and it has received widespread attention. Researchers have developed a variety of preparation technologies based on supercritical fluids. [0003] Supercritical Fluid Anti-solvent technology (Supercritical Fluid Anti-solvent, SAS) is a commonly used preparation technology, this technology first dissolves the compound or polymer of the desired preparation in a solvent ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01J2/00
CPCB01J2/006
Inventor 焦真王卫芳程江瑞宋俊颖韩赛
Owner SOUTHEAST UNIV