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Application of Chickpea Extract in Preparation of Drugs for Treating Androgen-Dependent Diseases

A chickpea, extract technology, applied in the field of medicine, can solve sexual dysfunction, feminization, adverse reactions and other problems

Active Publication Date: 2021-04-27
新疆维吾尔自治区分析测试研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some existing 5α-reductase inhibitors have been widely used clinically, but they all have strong adverse reactions, such as causing erectile dysfunction, abnormal sexual function, feminization of male breasts, etc.

Method used

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  • Application of Chickpea Extract in Preparation of Drugs for Treating Androgen-Dependent Diseases
  • Application of Chickpea Extract in Preparation of Drugs for Treating Androgen-Dependent Diseases
  • Application of Chickpea Extract in Preparation of Drugs for Treating Androgen-Dependent Diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0019] Chickpea Extract Inhibition of 5α-Reductase Activity:

[0020] 1.1 Experimental method:

[0021] 1.1.1 Preparation of Chickpea Extract:

[0022] a. Select chickpeas with well-proportioned size and full grains, wash them with clean water for 3 times, add pure water to soak them for 2 hours, cultivate them at 28°C, and change the water every 12 hours. After 72 hours, the chickpea sprouts will grow to 2cm. It is divided into three parts: germinated chickpea hypocotyl A, germinated chickpea cotyledon B, and germinated chickpea whole bean C. After being freeze-dried by a freeze dryer, the prototype is crushed to obtain the germinated chickpea hypocotyl A powder, germinated chickpea cotyledon B powder and germinated chickpea whole bean C powder;

[0023] b. Select chickpea dried beans in addition, and grind them with a crushing prototype machine to obtain ungerminated whole bean D powder of chickpeas;

[0024] c. Weigh the germinated chickpea hypocotyl A powder, germinated...

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Abstract

The present invention relates to the application of a chickpea extract in the preparation of medicines for treating androgen-dependent diseases. The preparation of the chickpea extract is to freeze-dry, pulverize, extract and concentrate the chickpea after germination to obtain Four components of chickpea germinated hypocotyl A, germinated chickpea cotyledon B, germinated chickpea whole bean C, and chickpea ungerminated whole bean D extract were carried out through the 5α-reductase in vitro screening model Through the screening of biological activity, the better active component is postgerminated hypocotyl A of chickpea, which has broad medical application prospects in the field of drugs for treating androgen-dependent diseases.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to the application of chickpea extracts in the preparation of medicines for treating androgen-dependent diseases. Background technique [0002] China has gradually entered an aging society, androgen-dependent diseases have received more and more attention, such as acne, hirsutism, androgenetic alopecia, benign prostatic hyperplasia (BPH) and prostate cancer. In particular, benign prostatic hyperplasia (BPH) is more common in middle-aged and elderly people. The incidence rate of men over 50 years old is nearly 40%, the incidence rate of men over 65 years old is nearly 70%, and the incidence rate of men over 70 years old is nearly 90%. For patients with BPH, due to the oppression of the urethra by the hypertrophy of the prostate tissue, it will cause poor urination and dysuria, and more serious cases may cause urinary retention, which is very painful for the patient. It can be seen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P5/28A23L33/105A61K131/00
CPCA23V2200/00A61K36/48A61K2236/333A61K2236/39A61K2236/51A23L33/105A61P5/28A23V2200/30A23V2250/21
Inventor 王苗苗李慕春韩飞
Owner 新疆维吾尔自治区分析测试研究院
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