Metal ion reagents and imaging preparations for early and rapid detection of malignant tumors and cardiovascular and cerebrovascular related diseases and multimodal imaging

A multi-modal imaging and metal ion technology, applied in the field of medical imaging, can solve the problems of poor targeting of preparations, weak signal strength, and high toxicity in vivo, and achieve simple and easy detection methods, avoid biological toxicity, and high sensitivity Effects of rapid tracing and monitoring

Active Publication Date: 2018-04-24
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, how to find a multimodal imaging agent that can be used for several imaging methods at the same time has become a new challenge. Many problems such as poor targeting of the agent, high toxicity in vivo, poor stability and weak signal intensity in vivo waiting to be resolved

Method used

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  • Metal ion reagents and imaging preparations for early and rapid detection of malignant tumors and cardiovascular and cerebrovascular related diseases and multimodal imaging
  • Metal ion reagents and imaging preparations for early and rapid detection of malignant tumors and cardiovascular and cerebrovascular related diseases and multimodal imaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Preparation of metal ion reagents

[0030] Preparation of metal ion reagents with excellent biocompatibility, the specific steps include:

[0031] The compound zinc chloride and europium sulfate were dissolved in ultrapure water respectively, and were prepared into a solution with a concentration of 10mmol / L; after mixing the zinc chloride solution and europium sulfate in equal proportions, they were mixed with 10mmol / L ferric chloride aqueous solution (chlorine Dissolve ferric oxide in ultrapure water) and mix according to volume 1:1 to obtain metal ion reagent.

[0032] 2. In vitro test

[0033]Application of the metal ion reagent of this embodiment to body fluid (such as blood or serum, etc.) or urine was tested, and the results showed that the optical and electrochemical properties of the tumor experimental group changed significantly after the metal ion reagent was added, while the normal control group did not change significantly.

[0034] Among them, the bo...

Embodiment 2

[0054] 1. Preparation of metal ion reagents

[0055] Preparation of metal ion reagents with excellent biocompatibility, the specific steps include:

[0056] The compound zinc gluconate was dissolved in ultrapure water to prepare a solution with a concentration of 10mmol / L; the zinc gluconate solution was mixed with 10mmol / L ferrous chloride aqueous solution at a volume ratio of 1:3 to obtain a metal ion reagent.

[0057] 2. In vitro test

[0058] Metal ion reagents were used to test body fluids (such as blood or serum, etc.) or urine, and the results showed that the optical and electrochemical properties of the tumor experimental group changed significantly after the addition of metal ion reagents, while the normal control group had no significant changes .

[0059] Among them, the body fluid comes from normal people and leukemia patients, and the urine comes from normal nude mice and tumor model nude mice. Tumor models in nude mice were liver cancer (HepG2 cell line) and c...

Embodiment 3

[0070] 1. Preparation of metal ion reagents

[0071] Preparation of metal ion reagents with excellent biocompatibility, the specific steps include:

[0072] The compound chloroauric acid and silver nitrate were dissolved in ultrapure water respectively, and both were prepared into a solution with a concentration of 10mmol / L; after mixing the chloroauric acid solution and the silver nitrate solution in equal proportions, they were mixed with 10mmol / L ferric chloride aqueous solution according to The volume is mixed at 1:2 to obtain the metal ion reagent.

[0073] 2. In vitro test

[0074] Metal ion reagents were used to test body fluids (such as blood or serum, etc.) or urine, and the results showed that the optical and electrochemical properties of the tumor experimental group changed significantly after the addition of metal ion reagents, while the normal control group had no significant changes .

[0075] Among them, the body fluid comes from normal people and leukemia pa...

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Abstract

A metallic ion reagent used for early rapid detection and multi-mode imaging of diseases related to malignant tumor and a cardiovascular disease, and an imaging preparation. The metallic ion reagent is a water solution containing metallic ions, and the metallic ions are prepared from at least one of ferric ions or ferrous ions, magnesium ions, transition metallic ions, rare earth metallic ions, and precious metallic ions; the transition metallic ions are one or a mixture of two of cerium ions and zinc ions; and a molar ratio of the ferric ions or the ferrous ions to other metallic ions is (5-1):1.

Description

technical field [0001] The invention relates to the field of medical imaging, in particular to a metal ion reagent and an imaging preparation for early rapid detection and multimodal imaging of malignant tumors and cardiovascular and cerebrovascular related diseases. Background technique [0002] Cancer, also known as malignant tumor, has become the biggest killer affecting human health and life in the 21st century. In clinical medical work, the discovery of malignant tumors mainly relies on inspection techniques such as imaging, pathology, and conventional tumor markers. The existing imaging methods commonly used in the diagnosis of tumors mainly include MRI (magnetic resonance imaging), SPECT (single photon emission tomography), PET (positron emission tomography), but these methods have certain limitations. It has been used clinically for many years, but it lacks sufficient sensitivity and specificity, and more importantly, it is difficult to detect tumors early. Early d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K49/06A61K49/22A61K49/00
CPCA61K49/00A61K49/04A61K49/06A61K49/22
Inventor 王雪梅赵春秋杜天宇任发来兰梅
Owner SOUTHEAST UNIV
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