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External composition, and preparation and application thereof

An external composition and preparation technology, applied in the field of medicine, can solve the problems of high recurrence rate, poor treatment effect, and damage to the balance of vaginal microenvironment, and achieve the effects of strong antibacterial properties, promoting the growth of granulation tissue, and improving the vaginal microenvironment

Active Publication Date: 2014-02-12
JIANGSU DIWO BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to overcome the defects of destroying the balance of vaginal microenvironment, poor treatment effect and high recurrence rate in the existing treatment of vaginal inflammation, and drug toxicity in the process of skin wound repair Effect disadvantages, the present invention provides a new pharmaceutical composition for vaginal inflammation and skin wound repair,

Method used

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  • External composition, and preparation and application thereof
  • External composition, and preparation and application thereof
  • External composition, and preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Embodiment 1: gel of the present invention

[0042] A gel used for repairing vaginal mucosa, cervical mucosa or skin wounds. The ingredients include chitosan, sodium hyaluronate, chlorhexidine and recombinant human epidermal growth factor. The mass percentage includes: 30000 parts of chitosan, 3000 parts of sodium hyaluronate, 3000 parts of chlorhexidine and 0.1 part of recombinant human epidermal growth factor.

[0043] Take the preparation of one kilogram of gel as an example,

[0044] 30g chitosan

[0045] 3g sodium hyaluronate

[0046] 3g chlorhexidine

[0047] 0.1mg recombinant human epidermal growth factor

[0048] Preparation:

[0049] (1) Add chitosan and sodium hyaluronate to 960 ml of purified water, and dissolve them with a disperser;

[0050] (2) Disperse chlorhexidine in 5 ml of propylene glycol;

[0051] (3) Add the chlorhexidine propylene glycol suspension into the above solution of chitosan and sodium hyaluronate, stir to mix the components ev...

Embodiment 2

[0055] Embodiment 2: gel agent of the present invention

[0056] A gel for repairing vaginal mucosa, cervical mucosa or skin wounds, comprising: 50,000 parts of chitosan, 1,000 parts of sodium hyaluronate, 1,000 parts of chlorhexidine acetate, 5 parts of recombinant human epidermal growth factor.

[0057] Take the preparation of one kilogram of gel as an example,

[0058] 50g chitosan

[0059] 1g sodium hyaluronate

[0060] 1g chlorhexidine acetate

[0061] 5mg recombinant human epidermal growth factor

[0062] Preparation:

[0063] (1) Add chitosan and sodium hyaluronate to 960 ml of purified water, and dissolve them with a disperser;

[0064] (2) Disperse chlorhexidine acetate in 5 ml of propylene glycol;

[0065] (3) Add the chlorhexidine acetate propylene glycol suspension into the above-mentioned solution of chitosan and sodium hyaluronate, and stir to mix the components evenly;

[0066] (4) Adjust the pH value of the solution between 5.0 and 6.0, and continue t...

Embodiment 3

[0069] Embodiment 3: gel agent of the present invention

[0070] A gel for repairing vaginal mucosa, cervical mucosa or skin wounds, comprising: 40,000 parts of chitosan, 1,000 parts of sodium hyaluronate, 2,000 parts of chlorhexidine gluconate, 0.4 parts of recombinant human epidermal growth factor.

[0071] Take the preparation of one kilogram of gel as an example,

[0072] 40g chitosan

[0073] 1g sodium hyaluronate

[0074] 2g Chlorhexidine Gluconate

[0075] 0.4mg recombinant human epidermal growth factor

[0076] Preparation:

[0077] (1) Add chitosan and sodium hyaluronate to 960 ml of purified water, and dissolve them with a disperser;

[0078] (2) Disperse chlorhexidine gluconate in 5 ml of propylene glycol;

[0079] (3) Add the chlorhexidine gluconate propylene glycol suspension into the above solution of chitosan and sodium hyaluronate, stir to mix the components evenly,

[0080] (4) Adjust the pH value of the solution between 5.0 and 6.0, and continue to ...

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Abstract

The invention relates to an external composition, and a preparation and an application thereof and belongs to the field of medicines. The external composition provided by the invention is a medicine composition which contains chlorhexidine or officinal salt thereof, or benzalkonium bromide or officinal salt thereof and a recombinant human epidermal growth factor or a recombinant cattle alkali fibroblast growth factor. According to the invention, the medicine composition is also further prepared into gel, liniment, ointment or paste, and the gel further comprises chitosan or officinal salt thereof and hyaluronic acid or officinal salt thereof. When being used for treating vagina inflammation, the external composition disclosed by the invention can improve a vagina microenvironment, promote growth of granulation tissue and repair vagina micro damage; and when being used for skin wound atraumatic restorative treatment, the external composition also can speed up restoration and regeneration of a wound tissue, promote healing and reduce scar formation, so that the external composition has a wide medical application prospect.

Description

technical field [0001] The invention relates to an external composition, preparation and application thereof, in particular to a pharmaceutical composition containing recombinant human epidermal growth factor and its medical application for preparing and treating vaginal inflammation or skin wound repair, belonging to the field of medicine. Background technique [0002] Vaginitis is a general term for a variety of vaginal mucosal inflammatory diseases caused by different etiologies. It is a common and frequently-occurring disease in gynecological outpatient clinics. Vaginal inflammation is mainly caused by bacteria, fungi, chlamydia, viruses, protozoa, etc. If the source of vaginal infection is not treated in time, it can go up to the uterine cavity, fallopian tubes, ovaries and pelvic cavity, resulting in acute and chronic endometritis, salpingitis, and ovarian inflammation Or pelvic inflammatory disease, in addition to inflammation symptoms, chronic infection may even caus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61K9/06A61P15/02A61P15/00A61P17/02A61K31/155A61K31/14
Inventor 贾峻峰
Owner JIANGSU DIWO BIOLOGICAL PROD
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