Dressing containing composite antibacterial microspheres

A compound antibacterial and microsphere technology, which is applied in medical science, pharmaceutical formulations, bandages, etc., can solve the problems of antibacterial effect to be improved, uneven distribution of nano-silver, and lack of mechanical properties of hydrogel dressings, so as to promote wound healing, Enhance mechanical properties and stability, avoid re-infection effect

Inactive Publication Date: 2018-12-07
安徽玉然经编科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, nano-silver particle hydrogel dressings still have the problems of uneven distribution of nano-silver, lack of mechanical properties of hydrogel dressings, and the antibacterial effect needs to be improved.

Method used

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  • Dressing containing composite antibacterial microspheres
  • Dressing containing composite antibacterial microspheres

Examples

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Embodiment 1

[0023] A dressing containing composite antibacterial microspheres, comprising the following raw materials by weight:

[0024] Antibacterial and anti-inflammatory extract 10, porous silicon dioxide 5, glacial acetic acid solution 30, silver nitrate solution 10, polyethylene glycol 1, chitosan 40, collagen 2, ammonium persulfate 1, N, N'-methylene Bisacrylamide 10;

[0025] Described glacial acetic acid solution mass concentration is 3%; Described silver nitrate solution mass concentration is 2%;

[0026] Further, the preparation method of the antibacterial and anti-inflammatory extract is as follows:

[0027] After cleaning 10 parts of orchid vanilla, 3 parts of mountain bean root and 10 parts of dandelion in parts by weight with warm water at 60°C, freeze-dry, and then carry out low-temperature pulverization treatment at 1°C in a low-temperature ultrafine pulverizer, To obtain a Chinese medicine powder with a fineness of 100 mesh, add the obtained Chinese medicine powder to ...

Embodiment 2

[0038] A dressing containing composite antibacterial microspheres, comprising the following raw materials by weight:

[0039] Antibacterial and anti-inflammatory extract 15, porous silicon dioxide 8, glacial acetic acid solution 40, silver nitrate solution 15, polyethylene glycol 2, chitosan 50, collagen 3, ammonium persulfate 2, N, N'-methylene Bisacrylamide 12;

[0040] Described glacial acetic acid solution mass concentration is 4%; Described silver nitrate solution mass concentration is 3%;

[0041] Further, the preparation method of the antibacterial and anti-inflammatory extract is as follows:

[0042] After cleaning 12 parts of blue vanilla, 1 part of mountain bean root, and 12 parts of dandelion in parts by weight with warm water at 65 ° C, freeze-dry, and then carry out low-temperature pulverization treatment at 2 ° C in a low-temperature ultrafine pulverizer, Obtain Chinese medicine powder with a fineness of 150 mesh, add the obtained Chinese medicine powder to 22 ...

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Abstract

The invention discloses a dressing containing composite antibacterial microspheres. The dressing has the advantages of safe, broad-spectrum antibacterial, long-acting antibacterial, anti-inflammatoryand anti-swelling. Furthermore, the sterilization speed is fast so as to avoid re-infection of wounds. Porous silica is used as a carrier, nano silver particles are synthesized in situ on the surfaceof the porous silica, and the porous silica adsorb an antibacterial and anti-inflammatory extract to form the composite antibacterial microspheres. The composite antibacterial microspheres has uniformdispersion and good stability and has good antibacterial and anti-inflammatory effects due to synergistic effect of all components. Furthermore, the porous structure of the composite microspheres arefully connected to the hydrogel dressing, thereby enhancing the mechanical properties and stability of the dressing. Added collagen can fade scars and promote wound healing. Good antibacterial and anti-inflammatory effects can be achieved through the reasonable combination of common bluebeard herb, radix sophorae tonkinensis, dandelion and plant ash, and the nano silver particles synergizes withthe materials so as to make the antibacterial and anti-inflammatory effect of the dressing remarkable. The dressing containing composite antibacterial microspheres can be used for treatment of skin defect inflection caused by various reasons in clinic.

Description

technical field [0001] The invention belongs to the technical field of dressings, in particular to a dressing containing composite antibacterial microspheres. Background technique [0002] As the largest organ of the human body, the skin plays an important role in maintaining and extending human life. The skin has the function of protecting the human body from physical and chemical damage, while preventing the invasion of microorganisms such as bacteria and maintaining the balance of body fluids and electrolytes. Various injury factors such as burns and trauma in life can lead to the destruction of skin structure and function, forming wounds, and the correct treatment of wounds is the key to the treatment of such diseases. Active wound management can effectively promote wound healing, improve prognosis and reduce disability. Wound dressings made of natural polymers can form a gel protective film on the wound surface, which has the advantages of biocompatibility, good degra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F251/00C08F222/38
CPCA61L26/0004A61L26/0033A61L26/0057A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L2300/104A61L2300/252A61L2300/30A61L2300/404A61L2300/41A61L2300/412A61L2300/45A61L2400/12C08F251/00C08F222/385
Inventor 张明
Owner 安徽玉然经编科技有限公司
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