Simultaneous determination of curcumin and 5-fluorouracil in plasma by hplc analysis method

A technology of fluorouracil and curcumin, which is applied in the field of HPLC analysis for simultaneous determination of the concentrations of curcumin and 5-fluorouracil in animal plasma, can solve problems such as gastrointestinal toxicity, bone marrow suppression, and clinical use restrictions, and achieve a simple and convenient pretreatment method. Effect of improving stability, saving analysis time and cost
CN108956816BActive Publication Date: 2021-12-24SOUTHWEST MEDICAL UNIVERISTY
0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHWEST MEDICAL UNIVERISTY
Publication Date
2021-12-24

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of pharmacokinetic analysis, and relates to an HPLC analysis method for simultaneously measuring the concentrations of curcumin and 5-fluorouracil in animal plasma. The initial steps include the preparation of standard solution, sample pretreatment, sample separation, detection of sample peak area and preparation of standard curve. The method overcomes the difficulty that curcumin and 5-fluorouracil are greatly different in polarity and is not easily eluted and separated in the same chromatographic system, and can simultaneously determine the concentrations of curcumin and 5-fluorouracil in plasma.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of pharmacokinetic analysis, and relates to an analysis and determination method of drugs in vivo, more specifically, relates to an HPLC analysis method for simultaneously determining the concentrations of curcumin and 5-fluorouracil in animal plasma. Background technique

[0002] Curcumin (CU) is a phenolic pigment extracted from the rhizomes of ginger plants such as turmeric. Curcumin is an orange-yellow crystalline powder with a slightly bitter taste and is insoluble in water. Modern studies have found that curcumin has the effects of lowering blood fat, anti-tumor, anti-inflammatory, choleretic, and anti-oxidation, and has good practicability and application prospects in the field of anti-cancer. 5-Fluorouracil (5-FU) is a pyrimidine anticancer drug, and it is also a first-line antineoplastic drug used clinically. It has good curative effect on various cancers (such as liver, stomach, pancreatic cancer a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More