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A kind of preparation method of absorbable antibacterial suture

A uniform mixing technology for sutures, which is applied in the fields of surgery, medical science, surgical instruments, etc., can solve the problems of poor compatibility and weak antibacterial ability of sutures, achieve good film-forming properties, improve compatibility, and inhibit ulcers Effect

Active Publication Date: 2021-05-25
HAINAN JIANKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Technical problem to be solved by the present invention: Aiming at the problem of poor compatibility of sutures and weak antibacterial ability, a preparation method of absorbable antibacterial sutures is proposed

Method used

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  • A kind of preparation method of absorbable antibacterial suture

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Embodiment Construction

[0028] Take 250~500g of hexafluoroisopropanol and 25~50g of trifluoroacetic acid and mix evenly to obtain solution A; take 30~60g of fresh cactus, peel off the thorns on the surface to obtain thornless cactus, and chop the thornless cactus Put in 50~100g of deionized water, cook for 1h, filter to remove the filter residue, and get solution B; take 50~100g of fresh pigskin, scrape off the pig hair and subcutaneous fat, put it into 100~200g of 40% 1mol / L sodium carbonate solution After 20 minutes, take out the pigskin and rinse it with 100g of 40°C deionized water for 3 to 5 times to obtain pretreated pigskin; take 80 to 160g of glacial acetic acid, 40 to 80g of sodium hydroxide and 1000 to 2000g of deionized water and mix them evenly. To obtain solution C, take 10~20g of sodium chloride and 100~200g of 0.1mol / L hydrochloric acid solution and mix to obtain solution D; take 2~4g of protease and 30~60g of pretreated pigskin and soak them in solution C at 60°C, stir and mix After 3...

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Abstract

The invention relates to a preparation method of absorbable antibacterial suture, which belongs to the field of medical biomaterials. The degradable antibacterial suture prepared by the present invention uses degradable chitosan and collagen as the main material of the suture, and chitosan has excellent biocompatibility, antibacterial anticorrosion, hemostasis, promotion of cell growth and wound healing, inhibition of Ulcers and other functions, good film-forming properties, high mechanical strength, biodegradability, pigskin is rich in collagen, collagen is negatively charged above the isoelectric point, and can be combined with positively charged chitosan to form polyamphoteric Electrolyte, to achieve performance complementarity and synergistic effect, showing good performance that the two materials do not have, while adjusting the ratio of the two components can regulate the performance of the material and improve the mechanical properties of the suture; together with cactus extract to achieve antibacterial Anti-inflammatory effect, the collagen of pigskin can improve the compatibility of sutures with the human body, and has good degradability and antibacterial properties.

Description

technical field [0001] The invention relates to a preparation method of absorbable antibacterial suture, which belongs to the field of medical biomaterials. Background technique [0002] With the continuous advancement of medical technology and textile engineering, textile materials are increasingly used in the medical industry. Medical surgical sutures are the most common biomedical textiles for surgical implants. They are widely used in various surgical operations to suture wounds, connect tissues and ligate blood vessels. Other wound closure techniques such as clips, staples, or tissue adhesives have evolved in recent years, but sutures remain the primary option for wound closure in most procedures. [0003] Sutures can be divided into absorbable sutures and non-absorbable sutures according to their biodegradability. Absorbable sutures are generally used in the suture of surgical incisions in the abdomen and ophthalmology, because they have excellent support strength in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10A61L17/08A61L17/00A61L17/06A61L17/14
CPCA61L17/005A61L17/06A61L17/08A61L17/10A61L17/14A61L2300/236A61L2300/30A61L2300/404A61L2300/41C08L5/08
Inventor 胡次兵周立杨顶建赵军钟冬雪
Owner HAINAN JIANKE PHARMA
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