Disease-associated protein database

A related protein and database technology, which is applied to the disease-related protein database. The application field of the database can solve the problems that the source of the database is not wide enough, the protein information cannot be updated in time, and the automatic update cannot be performed. It achieves friendly interface, convenient access, The effect of easy crawling

Active Publication Date: 2022-01-07
国家卫生健康委科学技术研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems or defects in the use of the current database: (1) The protein information in the current database cannot be updated in time. For example, Xi Hong’s database contains 34,891 pieces of data from OMIM, PMD, and SwissProt. These data are included in the database (2) The current database does not include a wide range of sources; (3) The current database is locally stored information, which is inconvenient to use; (4) The current database is mostly English information, which is difficult for Chinese users who have difficulty in English language barrier
(5) There are many existing databases without structural information

Method used

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  • Disease-associated protein database

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Construction of disease-associated protein database

[0037] Step 1: Collect disease-related protein data according to the following sources: (1) Collect disease-related gene mutation data recorded in OMIM and HGMD databases, and screen and compare the information of these disease genes with the structural database, and output the disease after matching the structure Data information of related proteins; (2) Collect disease-related protein information from PMD and Swissprot databases; (3) Collect disease-related protein data information uploaded by users. The above three types of information are completed according to disease-mutant gene-disease protein sequence-disease protein structure to form the complete data of disease-related proteins.

[0038] Select Allelic Variants, Clinical synopsis and Gene Map Locus of OMIM, polymorphisms and disease mutation of SwissProt as the source of disease-related gene or protein mutation database, and use web crawler techno...

Embodiment 2

[0045] Example 2 Application of disease-associated protein database

[0046] Taking the disease type as the search entry, search for Bart-Pumphrey (knuckle pads with white nails and deafness) in the database, the results are as follows: Figure 4 and Figure 5 shown.

[0047] Taking the human INPP5E protein as an example, search for the protein in the protein name search entry in the database. The search results are shown in 5.

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Abstract

The invention relates to a disease-related protein database and its construction method and application. The database has the characteristics of extensive collection of existing disease-related protein data information, timely updates, structural information, no local installation and fast access. At the same time, the construction method of the disease-related protein database and its application in scientific research are provided.

Description

technical field [0001] The present invention relates to the field of bioinformatics. Specifically, the present invention relates to a disease-related protein database, its construction method, and the application of the database. Background technique [0002] Protein is an important component of organisms and has important biological functions, such as acting as a biocatalyst, regulating metabolism, immune protection, transport and storage of substances, and intercellular signal transmission. The occurrence of many diseases is related to the variation of proteins in the body, such as sickle cell anemia, that is, due to gene mutations, the sixth amino acid residue at the N-terminus of the subunit is changed from a normal negatively charged polar hydrophilic glutamic acid residue (Glu) has become an uncharged non-polar hydrophobic valine (Val), that is, the normal protein is mutated into a disease-related protein, which makes the red blood cell distorted into a sickle shape, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B50/30G16B45/00
Inventor 马旭路建波
Owner 国家卫生健康委科学技术研究所
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