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Nerve repair catheter

A nerve repair and catheter technology, applied in the field of biomedical materials, can solve problems such as poor nerve repair effect, and achieve the effect of promoting regeneration and reconstruction, and improving the effect of defect nerve repair.

Active Publication Date: 2019-12-20
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing synthetic nerve repair catheters still have poor repair effects on nerves

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Take fresh pig dermis, manually remove excess fat tissue, and place the pig dermis in 2.5% mass fraction sodium hydroxide solution (weight of pig peritoneum: weight of sodium hydroxide solution=1:10) and 15% mass fraction peroxidation Hydrogen solution (weight of pig peritoneum: weight of hydrogen peroxide solution = 1:10) was alternately cleaned for 3 times, then soaked in acetone for degreasing treatment 3 times, then cleaned with ethanol, replaced with water for ethanol, and then frozen Dry to form dry decellularized dermis. The decellularized dermis is put into a mold for tableting. The mold has ridges that can be pressed to form ridges. Three continuous ridges form a group. The height of the ridges is 1mm. The length ratio of the raised part to the smooth part The ratio is 1:3. In the width direction, two adjacent groups of ridges are arranged parallel and juxtaposed at an interval of 5 mm. The tableting time is 10 hours, and the tableting strength is 10 MPa. ...

Embodiment 2

[0045] (1) Use 0.05N acetic acid to dissolve collagen (purchased from Shenzhen Lando Biomaterials Co., Ltd.) to form a 0.7% by weight collagen solution, which is then mixed with a chondroitin sulfate solution with a collagen content of 10% by weight, and placed in liquid nitrogen Use a homogenizer to homogenate fully under the conditions, inject the resulting solution into the mold, the mold has bulges, 4 continuous bulges form a group, the height of the bulge is 3mm, and the length ratio of the raised part to the smooth part in the length direction is 1 : 1, in the width direction, adjacent two groups of protuberances are arranged parallel and side by side at a distance of 2mm, then carry out freeze-drying at -60°C for h, add 0.2% by weight glutaraldehyde solution to carry out cross-linking for 24h after taking it out, and then use pure Wash with water 3 times, 8 hours each time, then freeze-dry at -60°C for 48 hours, cut to form a semi-finished adventitia, the length is 50mm,...

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Abstract

The present invention relates to a nerve repair catheter. The nerve repair catheter comprises a cylindrical inner core and an outer membrane that can surround the inner core. The inner core is provided with a first through hole extending in an axial direction and a second through hole extending in a direction perpendicular to the axial direction of the inner core. The nerve repair catheter can promote regeneration and reconstruction of neural tissues, and achieves better nerve defect repairing effects.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nerve repair catheter. Background technique [0002] In the case of a long peripheral nerve loss, the nerve repair cannot be completed by directly suturing the nerve stumps on both sides. The current mainstream repair method is to use autologous nerve graft, allogeneic nerve graft, xenogeneic nerve graft or synthetic nerve repair catheter. Autologous nerve transplantation will cause damage to the donor site. The method of allogeneic and xenogeneic nerve transplantation has the risk of transmitting diseases and viruses. Synthetic nerve repair catheter is an ideal repair method. However, the existing synthetic nerve repair catheters still have poor repair effects on nerves. Contents of the invention [0003] Based on this, it is necessary to provide a nerve repair catheter with better repair effect on the defective nerve. [0004] A nerve repair catheter, compri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61L27/36A61L27/24A61L27/50A61L27/56
CPCA61F2/02A61L27/362A61L27/24A61L27/50A61L27/56A61L2430/32
Inventor 潘洋魏欣苗陈雪霓佘振定谭荣伟
Owner SHENZHEN LANDO BIOMATERIALS
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