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Preparation method of crocetin microemulsion and freeze-dried powder of crocetin microemulsion

A technology of crocetin and microemulsion, which is applied in the field of preparation of crocetin microemulsion and its freeze-dried powder, can solve the problems of high cost, low production efficiency, high energy consumption, etc., and achieve the effect of increasing water solubility

Active Publication Date: 2018-12-28
嘉文丽(福建)化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The equipment is expensive, high energy consumption, and low production efficiency (common model processing capacity 10L / hr)

Method used

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  • Preparation method of crocetin microemulsion and freeze-dried powder of crocetin microemulsion
  • Preparation method of crocetin microemulsion and freeze-dried powder of crocetin microemulsion
  • Preparation method of crocetin microemulsion and freeze-dried powder of crocetin microemulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment one: the preparation of crocetin microemulsion

[0053] (1) Put 1.4g of potassium hydroxide and 0.05g of potassium citrate into a beaker, add 500ml of pure water and stir to dissolve; then add 10g of crocetin to the solution, heat and stir, filter, and cool to 5°C to obtain a solution A;

[0054] (2) Weigh 5.0g Tween-80 and 1.0g PEG1000, disperse and dissolve with 50ml pure water to obtain solution B;

[0055] (3) Weigh 5.3g of citric acid and dissolve it in 50ml of pure water to obtain solution C;

[0056] (4) Pour B into A and mix quickly; then pour C together into A and mix quickly to obtain a dark red transparent solution D, namely saffron acid microemulsion.

Embodiment 2

[0057] Embodiment two: the preparation of crocetin microemulsion

[0058] (1) Put 1.0g of sodium hydroxide and 0.05g of disodium EDTA into a beaker, add 500ml of pure water and stir to dissolve; then add 10.0g of crocetin to the solution, heat and stir, filter, cool to 10°C to obtain a solution A;

[0059] (2) Weigh 6.0g hydrogenated castor oil polyoxyethylene ether EL-40 and 1.5g CMC, disperse and dissolve with 50ml pure water to obtain solution B;

[0060] (3) Weigh 5.3g of citric acid and dissolve it in 50ml of pure water to obtain solution C;

[0061] (4) Pour B into A and mix quickly; then pour C together into A and mix quickly to obtain a dark red transparent solution D, namely saffron acid microemulsion.

Embodiment 3

[0062] Embodiment three: the preparation of crocetin freeze-dried powder

[0063] Get 100mL of the crocetin microemulsion solution in Example 1, add 15.0gD-mannitol, stir to make it dissolve completely, the solution is divided into 10mL vials, 2ml per bottle, and freeze-dry with reference to the following parameters , to obtain spongy saffron freeze-dried powder.

[0064] Table 1 Freeze-drying method

[0065]

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PUM

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a preparation method of crocetin microemulsion and freeze-dried powder of the crocetin microemulsion. Crocetin has strong antioxidant activity, has effects on cardiovascular protection, skin cancer inhibition and the like, and has potential application value in medicine, health food and cosmetics. However, crocetin is insoluble in water and common organic solvents, so that use of crocetin is severely limited. Based on the microemulsification principle, the method for effectively increasing water solubility of crocetin is provided, solubility of crocetin in water is increased by 800 times, the problem that crocetin is insoluble in water is solved, and a foundation is laid for the application of crocetin.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of crocetin microemulsion and freeze-dried powder thereof. Background technique [0002] Saffron is a kind of precious herbal medicine, which is native to the Mediterranean region. It has the functions of promoting blood circulation and removing blood stasis, cooling blood and detoxification, relieving stagnation and calming the nerves. Now studies have shown that the main active substance of saffron is crocin, which is hydrolyzed to remove gentiobiose to form crocetin. Crocetin has strong antioxidant activity, protects cardiovascular system, and inhibits skin cancer [1] It has potential application value in medicine and skin care products. However, the molecule of crocetin (relative molecular weight is 328g / mol) is smaller than that of crocin (relative molecular weight is 976g / mol), and it has a stronger adhesion to the skin. If it is...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/19A61K31/202A61K47/44A61K47/26A61P39/06A61P9/00A61P17/00A61P35/00
CPCA61K9/1075A61K9/19A61K31/202A61K47/26A61K47/44A61P9/00A61P17/00A61P35/00A61P39/06
Inventor 饶焕文林建平潘发伍林晓锋
Owner 嘉文丽(福建)化妆品有限公司
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