Application of GFA (Guanfu base A) in preparation of drug for neuropathic pain

A technology of neuropathic pain and Guanfu A, which is applied in the fields of nervous system diseases, drug combinations, and pharmaceutical formulations, can solve the problems of complex pathogenesis of chronic pain, impact on human health, and difficulty in pain treatment

Active Publication Date: 2018-12-28
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chronic pain seriously affects human health, and the treatment effect of most cases is poor
Du...

Method used

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  • Application of GFA (Guanfu base A) in preparation of drug for neuropathic pain
  • Application of GFA (Guanfu base A) in preparation of drug for neuropathic pain
  • Application of GFA (Guanfu base A) in preparation of drug for neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The Guanfu A preparation suitable for local or systemic application in the treatment of neuropathic pain is prepared by methods known in the art.

Embodiment 2

[0021] The Guanfu A preparation suitable for local or systemic application in the treatment of nerve injury-related diseases is prepared by methods known in the technical field.

[0022] In a word, Guanfu A can be used orally, injected, buccal tablets or other local or systemic dosage forms to prevent and treat the above diseases.

[0023] In order to better understand the essence of the present invention, below with regard to P2Y 12 The experiments and results of the research on the therapeutic effect of receptor-mediated related diseases are used to prove the use of Guanfu A.

[0024] 1. Materials and methods.

[0025] 1. Animal model making and grouping.

[0026] Healthy adult SD male rats were routinely fed in separate cages in a quiet, well-ventilated environment with a room temperature of 20-25°C and a relative humidity of 40%-60%, alternating day and night with light and dark for 12h / 12h, free access to drinking water, and changing cages and Litter, after adaptive fe...

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Abstract

The invention provides an application of GFA (Guanfu base A) in preparation of a drug for neuropathic pain. Experiments prove that GFA can reduce expression of a P2Y12 receptor of DRG (dorsal root ganglion) SGCs (satellite glial cells), inhibit transmission of nociceptive information mediated by a P2Y12 receptor and inflammatory factors in DRG and reduce pain behavior of rats suffering from neuropathic pain, and can be applied to preparation of the drug for neuropathic pain and diseases related to nerve injury.

Description

technical field [0001] The present invention relates to the field of invention of medicines for neuropathic pain, in particular to the application of Guanfu A in the preparation of medicines for reducing neuropathic pain caused by chronic compression injury of sciatic nerve, and its mechanism of action involves inhibiting purine in dorsal root ganglion 2Y (P2Y) 12 Receptor-mediated transmission of pain information. Background technique [0002] Pain is an unpleasant personal subjective sensation caused by tissue damage, including the pain sensation caused by noxious stimuli acting on the body, and the pain response caused by noxious stimuli, often accompanied by emotional changes of the patient. Pain is a common symptom of most diseases, but it is an unpleasant feeling with great individual differences. Patients often feel abnormal pain, anxiety, depression, sleep disturbance, lack of energy, mental breakdown and even personality distortion and other consequences. Accordi...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P25/00
CPCA61K31/439A61P25/00
Inventor 梁尚栋邹丽芳刘双梅应末凤李桂林高云
Owner NANCHANG UNIV
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