Hollow nanosphere with stable gastrointestinal tract and targeting intestinal microbial aggregation and preparation method thereof

A technology of intestinal microorganisms and nano-microspheres is applied in the field of preparation of hollow nano-microspheres, which can solve the problems of unfavorable drug delivery system in gastric stability, high solubility, instability, etc., so as to improve drug loading and facilitate absorption. And the effect of improving distribution and stability

Inactive Publication Date: 2019-01-18
FIRST AFFILIATED HOSPITAL GUIYANG UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan is highly soluble, unstable and easily degraded by lysozyme under acidi

Method used

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  • Hollow nanosphere with stable gastrointestinal tract and targeting intestinal microbial aggregation and preparation method thereof
  • Hollow nanosphere with stable gastrointestinal tract and targeting intestinal microbial aggregation and preparation method thereof
  • Hollow nanosphere with stable gastrointestinal tract and targeting intestinal microbial aggregation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A hollow nano-microsphere that is stable in the gastrointestinal tract and targets the aggregation of intestinal microorganisms. The raw material composition for preparing the hollow nano-microsphere is calculated in parts by weight:

[0025] (1) microsphere shell polymer: 10 parts of resistant starch, 5 parts of chitosan, 4 parts of lecithin, 100 parts of absolute ethanol;

[0026] (2) Nano-nuclear absolute ethanol solution: dissolve 1 part of sodium bicarbonate, 3 parts of water, and 20 parts of absolute ethanol.

[0027] Wherein the resistant starch is the resistant starch extracted from Radix Polygoni Multiflori.

[0028] A method for preparing hollow nano-microspheres that are stable in the gastrointestinal tract and target the aggregation of intestinal microorganisms comprises the following steps:

[0029] Step A: Preparation of microsphere shell polymer: 10 parts of resistant starch and 5 parts of chitosan were co-dissolved in water at a temperature of 90°C, ref...

Embodiment 2

[0034] A hollow nano-microsphere that is stable in the gastrointestinal tract and targets the aggregation of intestinal microorganisms. The raw material composition for preparing the hollow nano-microsphere is calculated in parts by weight:

[0035] (1) microsphere shell polymer: 15 parts of resistant starch, 5 parts of chitosan, 10 parts of lecithin, 150 parts of absolute ethanol;

[0036] (2) Nano-nuclear absolute ethanol solution: 2 parts of sodium bicarbonate solution, 10 parts of water, and 25 parts of absolute ethanol.

[0037] Wherein the resistant starch is the resistant starch extracted from Radix Polygoni Multiflori.

[0038] A method for preparing hollow nano-microspheres that are stable in the gastrointestinal tract and target the aggregation of intestinal microorganisms comprises the following steps:

[0039]Step A: Preparation of microsphere shell polymer: 15 parts of resistant starch and 5 parts of chitosan were co-dissolved in water at a temperature of 80°C, r...

Embodiment 3

[0044] A hollow nano-microsphere that is stable in the gastrointestinal tract and targets the aggregation of intestinal microorganisms. The raw material composition for preparing the hollow nano-microsphere is calculated in parts by weight:

[0045] (1) microsphere shell polymer: 12 parts of resistant starch, 4 parts of chitosan, 6 parts of lecithin, 200 parts of absolute ethanol;

[0046] (2) Nano-nuclear absolute ethanol solution: 3 parts of sodium bicarbonate solution, 15 parts of water, and 30 parts of absolute ethanol.

[0047] Wherein the resistant starch is the resistant starch extracted from Radix Polygoni Multiflori.

[0048] A method for preparing hollow nano-microspheres that are stable in the gastrointestinal tract and target the aggregation of intestinal microorganisms comprises the following steps:

[0049] Step A: preparation of microsphere shell polymer: 12 parts of resistant starch and 4 parts of chitosan were co-dissolved in water at a temperature of 85°C, r...

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Abstract

The invention discloses a hollow nanosphere with stable gastrointestinal tract and targeting intestinal microbial aggregation, wherein the hollow nanometer microsphere adopts resistant starch 10-15 part, chitosan 3-5 part co-dissolved at a temperature of 80 DEG C; 90 DEG C water, reflux 4-5 hour, vacuum concentrating and spin dry, then adding 4-10 part of lecithin, 10 times of total weight of absolute ethanol is added, and 2-3 hour, vacuum concentrating and rotate drying to obtain that microsphere shell polymer; Take 1-3 part of sodium bicarbonate is dissolved in 3-5 times the amount of water,and then slowly disperse it in 20-30 parts of anhydrous ethanol to obtain nano-nucleolus anhydrous ethanol solution, slowly adding the microsphere shell polymer into the anhydrous ethanol solution containing nano-nucleolus, stirring 5-10 min, adding 200 parts of water containing 0.2% octadecyl acrylate, stirring until ethanol is dried, adding 2-5% of glucose, lyophilize to obtain hollow nano-microsphere, wherein that hollow nano-microsphere disclosed by the invention can load a large numb of medicaments through the hollow inside, thereby increasing the drug loading amount of the medicaments;The outer layer has electronegative distribution of chitosan, which has the characteristics of improved stability and small particle size, and is helpful to the absorption and distribution of drugs.

Description

technical field [0001] The invention belongs to the field of preparation of hollow nano-microspheres, and in particular relates to a hollow nano-microsphere which is stable in the gastrointestinal tract and targets the aggregation of intestinal microbes and a preparation method thereof. Background technique [0002] Polygonum multiflorum is the dry root tuber of Polygonum multiflorum Thunb. The resistant starch prepared by extracting Polygonum multiflorum is of high quality and can resist enzymatic digestion in the stomach and duodenum, and the degradation rate is slow in the upper part of the gastrointestinal tract; in the lower part of the gastrointestinal tract, it is easily decomposed, absorbed and released by intestinal microorganisms Active substances such as short-chain fatty acids can be widely used as ideal carriers for oral drug delivery systems. [0003] Intestinal microbes are an important part of human health. They can ferment and decompose foreign substances, ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/36A61K47/24
CPCA61K9/5123A61K9/5161A61K9/5192
Inventor 阮婧华范东生杨莹陈艳周婵媛苏松柏于佳华玉玲万明香王道平
Owner FIRST AFFILIATED HOSPITAL GUIYANG UNIV OF CHINESE MEDICINE
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