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Novel cancer stem cell killing agent for gastric cancer and application thereof

A tumor stem cell and tumor technology, applied in the field of new gastric cancer tumor stem cell killers, can solve the problem of not finding Evacetrapib, and achieve good killing effect, good safety, and the effect of promoting apoptosis

Inactive Publication Date: 2019-01-18
SHENZHEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] As of December 2017, after searching Pubmed, Embase, and China Biomedical Literature Database (CMBdisc), we have not found any reports about Evacetrapib in tumor treatment, especially cancer stem cell therapy for gastric cancer

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  • Novel cancer stem cell killing agent for gastric cancer and application thereof
  • Novel cancer stem cell killing agent for gastric cancer and application thereof
  • Novel cancer stem cell killing agent for gastric cancer and application thereof

Examples

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Embodiment Construction

[0023] The following examples facilitate a better understanding of the present invention, but do not limit the present invention. The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the following examples were purchased from General Biochemical Reagent Company unless otherwise specified.

[0024] The following examples facilitate a better understanding of the present invention, but do not limit the present invention. The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the following examples were purchased from General Biochemical Reagent Company unless otherwise specified.

[0025] 1 Materials and methods

[0026] 1.1 The IC50 value of Evacetrapib was determined by CCK8 colorimetry, and the dose-effect curve and time-effect curve were drawn.

[0027] After in vitro expansion of two patient-derived gastric cancer stem ...

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Abstract

The invention discloses a novel application of a lipid-lowering drug Evacetrapib in the treatment of gastric cancer tumor stem cells. Using gastric cancer stem cells as a model, we found that Evacetrapib could not only inhibit the growth of gastric cancer cell line, but also promote its apoptosis. It can also inhibit the growth of gastric cancer stem cells and promote their apoptosis. The resultsshowed that Evacetrapib significantly inhibited the growth of transplanted tumor derived from gastric cancer stem cells. Western blot analysis showed that apoptosis-associated protein C-PARP The expression of increased in a concentration-dependent manner and the activation of STAT3 phosphorylation decreased in a concentration-dependent manner. The mechanism of Evacetrapib in the treatment of gastric cancer stem cells may be related to the inhibition of phosphorylation of STAT3. Therefore, Evacetrapib can be used as a new therapeutic drug for gastric cancer stem cells.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a novel gastric cancer tumor stem cell killing agent and its application. Background technique [0002] Chemotherapy based on cytotoxic drugs is the most important way in the treatment of advanced gastric cancer. However, cytotoxic drugs have poor specificity. While killing tumor cells, they also cause great damage to normal tissue cells in the body, seriously affecting the quality of life of cancer patients. Therefore, the search for drugs that target tumor-specific molecular changes, that is, molecularly targeted drugs, has sparked an upsurge of research. [0003] In 2002, the advent of the molecular targeted drug - imatinib mesylate (Gleevec) (the treatment of chronic myeloid leukemia has almost achieved the effect of clinical cure, and has low toxicity and high efficiency) triggered a change in the concept of anticancer treatment. It points out a new direction for tum...

Claims

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Application Information

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IPC IPC(8): A61K31/55A61P35/00
CPCA61K31/55A61P35/00
Inventor 陈铁李璟端王绍祥李晨阳舒兴盛常港陈家杰
Owner SHENZHEN UNIV
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