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Method for preparing Longmu Zhuanggu chewable tablet

A technology of Longmu bone strengthening and chewable tablets, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, bone diseases, etc. It can solve the problem that the extracted ingredients are greatly affected and the stability of vitamin D2 is not stable. Good, poor taste compliance and other issues

Active Publication Date: 2019-01-18
JIANMIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the more complex production process of chewable tablets, the stability of the product, especially the stability of vitamin D2, is not good
At the same time, due to the large amount of paste extracted from the medicinal materials of this product, it is difficult to form the preparation and the taste compliance is poor.
For this reason, CN104147344A has reported a kind of method that the extract of Longmu extract is purified by macroporous resin adsorption, which can reduce the dosage, reduce the bitter taste of medicine, and improve the mouthfeel when the granules are mixed with water, but the production cycle of this method is very long and the cost is very high. High, and the macroporous resin adsorption has a great impact on the extracted components, which will lead to the loss of a large amount of active components. Although this method has verified that it has little effect on the functions of strengthening the spleen and stomach, and promoting digestion and absorption, it may affect the kidney. Bone strengthening and other effects
In addition, CN107929512A reported a method for preparing Longmu Zhuanggu granules by ultra-high pressure extraction, which can increase the content of active ingredients in the extract and reduce impurities, thereby improving the efficacy of the drug, but this method still cannot improve the taste and compliance of chewable tablets

Method used

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  • Method for preparing Longmu Zhuanggu chewable tablet
  • Method for preparing Longmu Zhuanggu chewable tablet
  • Method for preparing Longmu Zhuanggu chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Prescription:

[0024]

[0025] 2. Preparation method:

[0026] 1) Prepare vitamin D2 inclusion compound by conventional solvent evaporation method, the specific method is: dissolve β-cyclodextrin in water, dissolve vitamin D2 with a small amount of ethanol, then add it to β-cyclodextrin aqueous solution, and stir until the solution All clarified, then rotary steamed, and vitamin D2 inclusion compound can be obtained after drying. At this time, vitamin D2 is embedded in the molecular cavity of β-cyclodextrin, which improves water solubility and stability.

[0027] 2) Codonopsis pilosula, Astragalus membranaceus, Ophiopogon japonicus, Tortoise shell, Atractylodes macrocephala, Chinese yam, Schisandra chinensis, keel, oyster, Poria cocos, jujube, licorice, chicken neijin. 2 hours for the second time, 1 hour for the third time, combine the extracts and concentrate to a relative density of 1.08 (measured at 75-85°C), let it cool, add ethanol to make the alcohol conte...

Embodiment 2

[0031] 1. Effect of inclusion amount of β-cyclodextrin on the stability of VD2

[0032] Set the amount of β-cyclodextrin to 0.6g, 1.2g, 1.8g, 3g, that is, 10 times, 20 times, 30 times, 50 times of VD2 respectively, prepare chewable tablets according to the method of Example 1, and the preparation is completed Afterwards, it was placed under the condition of relative humidity of 65% and temperature of 30° C. for 6 months of accelerated stability test, and the HPLC method was used to measure the VD2 content in the sample. The results are shown in Table 1 below.

[0033] Table 1 Effect of inclusion amount of β-cyclodextrin on stability of VD2 content (μg / tablet)

[0034] inclusion amount

[0035] It can be seen from the above results that when the inclusion amount is 30-50 times, the content of VD2 in the chewable tablet is relatively stable, and the content of the accelerated test for 6 months only drops by about 7%, while the inclusion amount is lower than 30 times W...

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Abstract

The invention discloses a method for preparing Longmu Zhuanggu chewable tablets. The method improves the preparation technology and optimizes the kinds and dosage of auxiliary materials, improves thecontent stability of vitamin D2, ensures the curative effect of the medicine, reduces the difficulty of the preparation, improves the taste of the medicine and improves the medication compliance.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of Longmu Zhuanggu chewable tablets. Background technique [0002] CN1466976A discloses a medicine for preventing and treating rickets and osteoporosis and a preparation method thereof. The medicine belongs to a compound preparation of Chinese and Western medicines, and is compatible with Chinese medicines for invigorating the spleen and invigorating the kidney, so as to exert the effects of invigorating the spleen and stomach, and strengthening tendons and bones. It is used for the treatment and prevention of rickets and rickets in children. The drug is the exclusive variety of Jianmin Pharmaceutical Group Co., Ltd., and the product name is Longmu Zhuanggu Granules. It is recorded in the 2015 edition of the "Chinese Pharmacopoeia". It is a national protected traditional Chinese medicine. "Longmu" is a well-known trademark in China. . [0003] Longmu Zhu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/20A61K47/69A61P19/08A61P19/10A61K35/618A61K35/586A61K35/57A61K35/02A61K31/592A61K31/191A61K31/19
CPCA61K9/0056A61K9/2018A61K9/2095A61K31/19A61K31/191A61K31/592A61K35/02A61K35/57A61K35/586A61K35/618A61K36/076A61K36/284A61K36/344A61K36/481A61K36/484A61K36/57A61K36/725A61K36/79A61K36/8945A61K36/8968A61K2236/331A61K2236/55A61K47/6951A61P19/08A61P19/10A61K2300/00
Inventor 黄志军向阳吴保明曾庆恢明凯利曾添
Owner JIANMIN PHARMA GRP CO LTD
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