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Application of FG4592 in the preparation of products for treatment of hypertension

A technology for hypertension and essential hypertension, applied in the application, the function of food ingredients, and medical preparations containing active ingredients, etc., can solve the problems of increasing the risk of diabetes and increasing the risk of adverse renal events.

Inactive Publication Date: 2019-01-25
NANJING CHILDRENS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

β-blockers can be combined with diuretics to reduce blood pressure, but due to the increased risk of diabetes, there should be certain restrictions on their use
Combination of two RAAS blockers (ramipril + telmisartan) was associated with increased risk of hypotension, hyperkalemia, and adverse renal events

Method used

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  • Application of FG4592 in the preparation of products for treatment of hypertension
  • Application of FG4592 in the preparation of products for treatment of hypertension
  • Application of FG4592 in the preparation of products for treatment of hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Forty 8-week-old C57BL / 6J mice were divided into 4 groups with 10 mice in each group. AngII sustained-release preparation was used as the model of essential hypertension and treated with FG4592. The first group was injected intraperitoneally with solvent as the normal control group, the second group was injected with FG4592 as the FG4592-dosed group, the third group was given AngII sustained-release agent as the hypertension group, and the fourth group was administered AngII sustained-release agent and intraperitoneally injected FG4592 as the hypertensive group For FG4592 group. The concentration of AngII used in each mouse was 1.4mg / kg / d, and the concentration of FG4592 injected in each mouse was 10mg / kg / d.

[0031] Tail-cuff monitored the blood pressure of all mice daily for 21 days. It was found that the blood pressure of the hypertensive mice given intraperitoneal injection of FG4592 in the fourth group was basically close to the blood pressure of the normal mice ...

Embodiment 2

[0040] According to the method of Example 1, the AngII slow-release agent was used as the secondary hypertension model, and the other steps were unchanged, and the experiment was carried out. From the results, FG4592 can improve secondary hypertension. At the animal level, the cure rate is 99.9%. It can also improve heart and blood vessel function and reduce urine output, and has no toxic side effects on liver and kidney.

[0041] Using FG4592 in Example 1 for patients with essential hypertension and secondary hypertension will also have a significant antihypertensive effect. According to records, whether it is patients with essential hypertension or secondary hypertension For blood pressure patients, the cure rate is as high as 99.9%, and it improves the function of the heart and blood vessels, and has no toxic side effects on the liver and kidneys.

Embodiment 3

[0043] A blood pressure-lowering functional drink, including a basic component and an active component, the active component is FG4592, wherein the drinking amount of FG4592 shall not exceed 2mg / kg / d.

[0044] The basic components include the following components in parts by weight: 20 parts of mulberries, 5 parts of green tea, 10 parts of Dendrobium candidum, 20 parts of corn silk, 10 parts of poplar leaves, 1 part of banana peel, 2 parts of ginkgo leaves, lotus 4 parts of leaves, 3 parts of licorice, 1 part of fat sea, 3 parts of wolfberry, 0.2 parts of vitamin E, 0.1 part of vitamin B, 1 part of natto, 45 parts of deionized water.

[0045] Specifically, after cleaning mulberry, green tea, Dendrobium candidum, corn silk, poplar leaves, banana peel, ginkgo leaves, lotus leaves, licorice, fat sea, wolfberry, and natto, they are placed in a grinder and pulverized, and then used Put the gauze wrap in deionized water and cook on medium heat for 1-3 hours. After cooling naturally,...

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Abstract

The invention belongs to the field of pharmaceutical application, and particularly discloses the application of FG4592 in preparing products for treating hypertension. FG4592 and control solvent wereinjected intraperitoneally to establish mouse hypertension model and normal mice respectively. Tail-cuff was used to monitor the blood pressure of mice for 21 days, and echocardiography was used to detect the cardiac function. The results showed that the blood pressure and cardiac function of hypertensive mice treated with FG4592 could be maintained in normal range, while the blood pressure of normal mice treated with FG4592 was not affected. 21 day later, heart pathological examination showed that the blood vessel morphology of hypertensive mice treated with FG4592 was similar to that of normal mice, and the left ventricular hypertrophy was significantly alleviated. The product prepared by FG4592 had the effects of lowering blood pressure, improving blood vessel and left ventricle, and reducing the occurrence of adverse cardiovascular events, and had no toxic effect.

Description

technical field [0001] The invention relates to the field of hypertension treatment, in particular to the application of FG4592 in the preparation of products for treating hypertension. Background technique [0002] Hypertension is a major global health problem. At present, about one-third of American adults suffer from high blood pressure. There are as many as 300 million hypertensive patients in my country, and 86 million hypertensive patients have been included in community management. The blood pressure control rate is 27 %. Worldwide, high blood pressure is the leading cause of heart disease and stroke. Rational use of drugs to control blood pressure can significantly reduce the mortality rate caused by hypertension. There are three major categories of antihypertensive drugs currently on the market: drugs related to the renin-angiotensin-aldosterone system, drugs related to the angiotensin-converting enzyme 2 / angiotensin (1-7) / MAS receptor axis, and drugs targeting ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/472A61P9/12A23L33/10A23L2/38
CPCA61P9/12A23L2/38A23L33/10A61K31/472A23V2002/00A23V2200/326
Inventor 于婧贾占军周玮王淑琴
Owner NANJING CHILDRENS HOSPITAL
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