A kind of artificial articular cartilage and preparation method thereof

A technology for artificial joints and cartilage, applied in joint implants, joint implants, and other household appliances, can solve the problem of weakening the intermolecular force of polyvinyl alcohol hydrogel and affecting the fatigue resistance and wear resistance of materials , Biological safety needs to be verified and other issues, to achieve the effect of maintaining victory sports function, improving anti-infection performance, and improving fatigue resistance

Active Publication Date: 2021-06-29
孙乐青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the artificial hose material described in patent CN 106552286 A, the content of polyvinyl alcohol is controlled between 15% and 20%, and the polyvinyl alcohol hydrogel in this content range is loose and porous after being cross-linked, with a large pore size , Bacteria are very easy to invade. Once infected, bacteria tend to multiply rapidly inside the material, but it is difficult for antibiotics to enter the material to kill bacteria, so the risk of clinical use is relatively high. In addition, whether the mechanical properties of this range can meet the long-term requirements of the human body Key technical issues such as whether it can carry complex physiological activities of the human body have yet to be verified.
[0007] In the patent CN 107419654 A, the antibacterial material is added to the material to enhance the infection ability of the material. Although the antibacterial performance of the material has been improved, the biological safety of the added material has yet to be verified. If too much is added, the force between the molecules of polyvinyl alcohol hydrogel will be weakened, resulting in limited crosslinking ability of the material, which will inevitably affect the fatigue resistance and wear resistance of the material

Method used

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  • A kind of artificial articular cartilage and preparation method thereof
  • A kind of artificial articular cartilage and preparation method thereof
  • A kind of artificial articular cartilage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 A kind of preparation method of artificial articular cartilage, the steps are as follows:

[0038] (1) Take 20g of polyvinyl alcohol raw material (the average degree of polymerization is between 1000 and 1900), add it to 100mL of water, heat it to 95°C, stir it mechanically, control the stirring speed at 300r / min, and stir it at a constant temperature under reflux for 6 hours. After the vinyl alcohol is completely dissolved, the solution is a transparent viscous liquid;

[0039] (2) Then turn off the heating, cool naturally to 60°C, stop stirring, let it stand for 2 hours, then pour the slime into the mold, quickly place it in a -20°C environment and freeze it for 16 hours, and then heat up at a rate of 5°C / h to -5°C, then raise the temperature to 5°C at a rate of 1°C / h, hold for 2 hours, then raise the temperature to 25°C at 5°C / h, and hold for 2 hours, thus completing a freeze-thaw self-assembly process, repeat this process process 5 times, and then cros...

Embodiment 2

[0040] Embodiment 2 Change the addition of polyvinyl alcohol and water to be 20g and 80ml respectively, all the other conditions remain unchanged, repeat the test according to the experimental conditions mentioned in Example 1, repeat the test, the sample number is marked as 2-02;

Embodiment 3

[0041] Embodiment 3 Change the addition of polyvinyl alcohol and water to be 40g and 100ml respectively, all the other conditions remain unchanged, repeat the test according to the experimental conditions mentioned in Example 1, repeat the test, and the sample number is marked as 2-03;

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Abstract

The invention is an artificial articular cartilage, which is characterized in that it is prepared from the following raw materials: polyvinyl alcohol and water, the molecular weight of the polyvinyl alcohol raw material ranges between 1000-1900, and the polyvinyl alcohol and water The feed ratio is 15%~70% (w / v). The resulting product improves the anti-infection ability of the material, reduces the risk of implantation in clinical operations, and significantly improves the comprehensive mechanical properties of the material, including compressive strength, Fatigue resistance and wear resistance, etc.

Description

technical field [0001] The invention relates to artificial articular cartilage and a preparation method thereof, belongs to the technical fields of medical equipment, biological materials, and medical materials, and is a key material used as articular cartilage replacement for treating arthritis. Background technique [0002] Arthritis generally refers to inflammatory diseases that occur in human joints and their surrounding tissues and are caused by inflammation, infection, degeneration, trauma or other factors, mainly including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, reactive joints arthritis, gouty arthritis etc. According to statistics, there are more than 100 million arthritis patients in my country, and the number is constantly increasing. Among them, half of the people over the age of 50 suffer from osteoarthritis, and 90% of women and 80% of men over the age of 65 suffer from osteoarthritis. About 10 to 15 years shorter. Arthritis is a disease ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/50A61F2/30B29C39/02B29K29/00
CPCA61F2/30756A61F2/30771A61F2002/30224A61F2002/30822A61L27/16A61L27/50A61L2430/06B29C39/003B29C39/02B29K2029/04B29L2031/7532C08L29/04
Inventor 柳仁民孙乐青
Owner 孙乐青
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