Traditional Chinese medicine composition for treating diabetes and preparation method and application of traditional Chinese medicine composition
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A composition and diabetes technology, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of chemical drugs such as diabetic patients suffering, and achieve scientific and reasonable distribution ratio of traditional Chinese medicine, significant effect, and reliability highly operable effect
Active Publication Date: 2019-02-22
ZHEJIANG UNIV
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Problems solved by technology
At present, there are many types of anti-type 2 diabetes chemical drugs used in clinical treatment on the market, mainly including: sulfonamides, glinides, thiazolidinediones (TZDs) PPARs agonists, α-glucosidase However, existing drugs have been found to have many toxic and side effects clinically, such as osteoporosis (Loke, Y.K.; Singh, S; Furberg, C.D. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta -analysis.Canadian Medical AssociationJournal.2009,18(1),32-39.), hypertension, inflammation, heart failure, edema, obesity (Willson,T.M; Brown,P.J.; Sternbach,D.D.; Henke,B.R.The PPARs: From orphan receptors to drug discovery.Journal of Medicinal Chemistry.2000,43(4),527-550.; Bloomgarden,Z.T.Thiazolidinediones.DiabetesCare.2005,28(2),488-493), and even cancer risk etc. (Handelsman, Y.; LeRoith, D.; Bloomgarden, Z.T.; Dagogo-Jack, S.; Einhorn, D.; , C.H.Diabetes and cancer-an AACE / ACE consensus statement. Endocrine Practice. 2013, 19(4), 675-693.)
The secondary failure of chemical drugs also makes diabetic patients miserable
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Embodiment 1
[0018] Embodiment 1: the preparation of oral liquid
[0019] Take raw material medicine by weight: Atractylodes macrocephala 60kg, Curcuma 60kg, Angelica 40kg, Shichangpu 40kg, Radix Puerariae 40kg, decoct 2 times with water, add 16 times of water for the first time, add 10 times of water for the second time, Combine the decoction liquids, filter them, concentrate to an appropriate volume, add preservatives and seasonings in appropriate amounts, and pack them into oral liquids.
Embodiment 2
[0020] Embodiment 2: the preparation of pill
[0021] Take by weight raw materials: Atractylodes macrocephala 5kg, Curcuma 5kg, Angelica 1kg, Shichangpu 1kg, Pueraria radix 1kg, reflux extraction with 20% ethanol for 2 times, add 12 times the amount of solvent for the first time, add 8 times the amount for the second time Solvent, combined extracts, filtered, concentrated to extract, dried, crushed into fine powder, mixed with appropriate amount of binder, wetting agent, disintegrating agent, etc., watered into pills, coated and dried.
Embodiment 3
[0022] Embodiment 3: the preparation of tablet
[0023] Take raw material medicine by weight: Atractylodes macrocephala 10kg, Curcuma 30kg, Angelica 8kg, Shichangpu 5kg, Radix Puerariae 9kg, reflux extraction 2 times with 95% ethanol, add 10 times of solvent each time, filter after merging the extract, concentrate to For the extract, add appropriate amount of filler, binder and disintegrating agent, mix evenly, granulate, add lubricant, and compress into tablets to obtain.
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Abstract
The invention discloses a traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition is prepared from five raw material medicines: rhizoma atractylodis macrocephalae, radix curcumae, radix angelicae sinensis, rhizoma acori tatarinowii and lobed kudzuvine root.; eExtracting is conducted through water or a water/alcohol solvent system, then all pharmaceutical excipients are added, thus various oral preparations which are acceptable medically are prepared, and the preparation types are oral liquid, tablets, pills, granules or capsules. A traditional Chinese medicine prescription formula theory is fully utilized, the selected medicines has the effects of nourishing yin and tonifying qi, activating blood and removing stasis, and tonifying yin and yang and achieves the mutual supplement effect; the overall concept and the coordination concept of a traditional Chinese medicine formula are fully embodied, the effect is remarkable through clinical verification, and the traditional Chinese medicine composition has an the obvious effect on improvement for various symptoms caused by the diabetes after long-term administration; a preparation technology of a traditional Chinese medicine compound preparation is simple, stable, high in operability and suitable for industrial production; and the traditional Chinese medicine preparation is safe and nontoxic -toxic, and a novel type- 2 diabetes resisting medicine which has the remarkable curative effect and is convenient to use is provided for patients.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound traditional Chinese medicine preparation for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes mellitus is a metabolic disease that causes hyperglycemia due to absolute or relative insufficiency of insulin secretion in the body. It can cause a series of chronic complications in multiple systems based on vascular disease and neuropathy, leading to disability or death of patients. Diabetes is clinically divided into type 1 (insulin-dependent) and type 2 (non-insulin-dependent), of which type 2 diabetes accounts for more than 90%, the main reason is insulin resistance (insulin resistance, IR), that is, due to the Insulin target tissues (such as fat, muscle, liver, etc.) are less sensitive to insulin, and tissue cells lack glucose utilization mediated by insulin, resulting in hyperglycemia and a series of diabetic symptoms...
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