Traditional Chinese medicine composition for treating diabetes and preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition is prepared from five raw material medicines: rhizoma atractylodis macrocephalae, radix curcumae, radix angelicae sinensis, rhizoma acori tatarinowii and lobed kudzuvine root.; eExtracting is conducted through water or a water / alcohol solvent system, then all pharmaceutical excipients are added, thus various oral preparations which are acceptable medically are prepared, and the preparation types are oral liquid, tablets, pills, granules or capsules. A traditional Chinese medicine prescription formula theory is fully utilized, the selected medicines has the effects of nourishing yin and tonifying qi, activating blood and removing stasis, and tonifying yin and yang and achieves the mutual supplement effect; the overall concept and the coordination concept of a traditional Chinese medicine formula are fully embodied, the effect is remarkable through clinical verification, and the traditional Chinese medicine composition has an the obvious effect on improvement for various symptoms caused by the diabetes after long-term administration; a preparation technology of a traditional Chinese medicine compound preparation is simple, stable, high in operability and suitable for industrial production; and the traditional Chinese medicine preparation is safe and nontoxic -toxic, and a novel type- 2 diabetes resisting medicine which has the remarkable curative effect and is convenient to use is provided for patients.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound traditional Chinese medicine preparation for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes mellitus is a metabolic disease that causes hyperglycemia due to absolute or relative insufficiency of insulin secretion in the body. It can cause a series of chronic complications in multiple systems based on vascular disease and neuropathy, leading to disability or death of patients. Diabetes is clinically divided into type 1 (insulin-dependent) and type 2 (non-insulin-dependent), of which type 2 diabetes accounts for more than 90%, the main reason is insulin resistance (insulin resistance, IR), that is, due to the Insulin target tissues (such as fat, muscle, liver, etc.) are less sensitive to insulin, and tissue cells lack glucose utilization mediated by insulin, resulting in hyperglycemia and a series of diabetic symptoms...

AI Technical Summary

Problems solved by technology

At present, there are many types of anti-type 2 diabetes chemical drugs used in clinical treatment on the market, mainly including: sulfonamides, glinides, thiazolidinediones (TZDs) PPARs agonists, α-glucosidase However, existing drugs have been found to have many toxic and side effects clinically, such as osteoporosis (Loke, Y.K.; Singh, S; Furberg, C.D. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta -analysis.Canadian Medical AssociationJournal.2009,18(1),32-39.), hypertension, inflammation, heart failure, edema, obesity (Willson,T.M; Brown,P.J.; Sternbach,D.D.; Henke,B.R.The PPARs: From orphan receptors to drug discovery.Journal of Medicinal Chemistry.2000,43(4),527-550.; Bloomgarden,Z.T.Thiazolidinediones.DiabetesCare.2005,28(2),488-493), and even cancer risk etc. (Handelsman, Y.; LeRoith, D.; Bloomgarden, Z.T.; Dagogo-Jack, S.; Einhorn, D.; , C.H.Diabetes and cancer-an AACE / ACE consensus statement. Endocrine Practice. 2013, 19(4), 675-693.)

The secondary failure of chemical drugs also makes diabetic patients miserable

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