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Preparation method of pharmaceutical composition used for treating gout

A technology of composition and medicine, which is applied in the field of preparation of pharmaceutical compositions, can solve the problems of unsuitability for the elderly, obvious side effects, single effect, etc., and achieve the effect of improving bioavailability, less side effects, and simple preparation method

Inactive Publication Date: 2019-03-05
闵键
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the medicines currently on the market have single effects, are expensive, and have obvious side effects, and are not suitable for the elderly suffering from gout. Therefore, it is urgent to research and develop a compound medicine for treating gout with good curative effect, low cost, and few side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Party:

[0017] 40 parts of ephedra, 35 parts of Wujiapi, 25 parts of cocklebur, 10 parts of Huoxiang, 10 parts of gentian, 4 parts of clove, and 4 parts of ground dragon.

[0018] Preparation:

[0019] (1) The above-mentioned raw materials are weighed according to the formula ratio, and the dried ephedra, Wujiapi and Xanthium are crushed through a 120-mesh sieve, immersed in water, decocted with a slow fire, combined with decoction and filtered to obtain filtrate A;

[0020] (2) Grind the dried patchouli, gentian, clove, and earthworm after drying, pass through a 60-mesh sieve, add distilled water twice the total weight of the patchouli, gentian, clove, and earthworm, and heat to boil. Filter, and filtrate B is standby;

[0021] (3) Mix filtrate A and filtrate B, add ethanol with a volume fraction of 70% and soak for 4 hours, after all the ethanol volatilizes, add distilled water to mix, concentrate and dry to obtain concentrate C;

[0022] (4) The auxiliary materia...

Embodiment 2

[0024] Party:

[0025] 58 parts of ephedra, 55 parts of Wujiapi, 45 parts of cocklebur, 18 parts of Huoxiang, 15 parts of gentian, 8 parts of clove, and 6 parts of ground dragon.

[0026] Preparation:

[0027] (1) The above-mentioned raw materials are weighed according to the formula ratio, and the dried ephedra, Wujiapi and Xanthium are crushed through a 150-mesh sieve, immersed in water, decocted with a slow fire, combined with decoction and filtered to obtain filtrate A;

[0028] (2) Grind the dried patchouli, gentian, clove, and earthworm after drying, pass through an 80-mesh sieve, add distilled water 4 times the total weight of the patchouli, gentian, clove, and earthworm, and heat to boil. Filter, and filtrate B is standby;

[0029] (3) Mix filtrate A and filtrate B, add ethanol with a volume fraction of 80% and soak for 4 hours, after all ethanol volatilizes, add distilled water to mix, concentrate and dry to obtain concentrate C;

[0030] (4) The auxiliary material...

Embodiment 3

[0032] Party:

[0033] 50 parts of ephedra, 45 parts of Wujiapi, 32 parts of cocklebur, 15 parts of Huoxiang, 13 parts of gentian, 6 parts of clove, and 5 parts of dried earthworm.

[0034] Preparation:

[0035] (1) The above-mentioned raw materials are weighed according to the formula ratio, and the dried ephedra, Wujiapi and Xanthium are crushed through a 135-mesh sieve, immersed in water, decocted with a slow fire, combined with decoction and filtered to obtain filtrate A;

[0036] (2) Grind the dried patchouli, gentian, clove, and earthworm after drying, pass through a 70-mesh sieve, add distilled water 3 times the total weight of the patchouli, gentian, clove, and earthworm, and heat to boil. Filter, and filtrate B is standby;

[0037] (3) Mix filtrate A and filtrate B, add ethanol with a volume fraction of 75% and soak for 3 hours, after all the ethanol volatilizes, add distilled water to mix, concentrate and dry to obtain concentrate C;

[0038] (4) The auxiliary mat...

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Abstract

The invention discloses a preparation method of a pharmaceutical composition used for treating gout. The preparation method comprises following steps: 1, dried ephedra stem, cortex acanthopanacis, andfructus xanthii are crushed and sieved, are immersed in water, and are subjected to decoction with slow fire, obtained decoction solutions are mixed and filtered so as to obtain a filtrate A; 2, wrinkled gianthyssop herb, radix geutianae, clove, and dried lumbricus are dried, grinded, and sieved so as to obtain a mixture, the mixture is added into distilled water for heating to boiling, cooling is carried out, and filtering is carried out so as to obtain a filtrate B for further processing, wherein the amount of the distilled water accounts for 2 to 4 times of that of the mixture; 3, the filtrate A and the filtrate B are mixed, ethanol is added for immersion, distilled water is added for uniform mixing, and concentration drying is carried out so as to obtain a concrete C; and 4, accessoryingredients are added into the concentrate C so as to obtain a finished product dosage needed in clinical treatment. Compared with the prior art, the advantages are that: the preparation method is simple; both human labor and cost are saved; optimal utilization of raw materials is realized; the bioavailability is high; the pharmaceutical composition prepared using the preparation method is excellent in curative effect, low in cost and side effect, and is suitable for old people with gout.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a preparation method of the pharmaceutical composition for treating gout. Background technique [0002] Gout is a crystal-associated arthropathy caused by the deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by purine metabolic disorders and / or decreased uric acid excretion, especially acute characteristic arthritis and Chronic tophi diseases mainly include acute onset arthritis, tophi formation, tophi chronic arthritis, urate nephropathy and uric acid urolithiasis. In severe cases, joint disability and renal insufficiency may occur. Gout is often accompanied by abdominal obesity, hyperlipidemia, hypertension, type 2 diabetes, and cardiovascular disease. The most important biochemical basis of gout is hyperuricemia. A normal adult produces about 750 mg of uric acid per day, of which 80% is endogenous and 20% is exogenous uric acid. These uric...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61P19/06A61K35/62
CPCA61K36/17A61K35/62A61K36/254A61K36/28A61K36/515A61K36/532A61K36/61A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 闵键
Owner 闵键
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