Method for establishing insulin resistance animal model
A technology of insulin resistance and animal models, applied in animal feed, additional food elements, applications, etc., can solve the problems of low stability of animal models, excessive difference in results, and differences in the degree of pathogenicity of modeling, so as to eliminate adverse reactions , low cost, and avoid the effect of model instability
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[0021] The establishment method of insulin resistance animal model, including selection of mouse species, grouping and modeling, blood collection and detection, by simultaneously feeding high-sugar, high-fat and high-selenium feed and drinking fructose solution to cause glucose and lipid metabolism disorder, and then induce male mice to produce insulin Resistance, to obtain insulin resistance animal models. The high-sugar, high-fat and high-selenium feed of the present invention is prepared by adding lard, sucrose, cholesterol, sodium selenate, potassium sorbate and pig bile salt to conventional experimental animal feed; the fructose solution is prepared by adding distilled water of analytical grade. The specific construction process and test results are as follows:
[0022] 1. Experimental reagents and instruments
[0023] Mouse insulin enzyme-linked immunoassay kit, Beijing Keyingmei Technology Co., Ltd., batch number: 17072401. Cholesterol (TC), triglyceride (TG), low-den...
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