Sodium selenite vitamin C injection and preparation method thereof
A technology for sodium selenite and vitamins, which is applied in pharmaceutical formulations, sulfur/selenium/tellurium active ingredients, and non-active ingredients medical preparations, etc. big problem
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[0014] The invention provides a kind of preparation method of sodium selenite vitamin C injection, comprises the following steps:
[0015] (1) First add edetate disodium, sodium metabisulfite and selenous acid to the water for injection saturated with carbon dioxide, and then add vitamin C after completely dissolving, stir to completely dissolve vitamin C, then add sodium bicarbonate and finally add water for injection Constant volume, obtain mixed solution;
[0016] (2) Add medicinal activated carbon to the mixed solution described in step (1), filter and decarburize after stirring, and fine filter the filtered filtrate with an ultrafiltration membrane; then continue to feed carbon dioxide gas into the filtrate after fine filtration , sterilized after potting under the condition of passing carbon dioxide to obtain an injection solution.
[0017] In the above technical solution, the production process of the preparation method of the present invention is simple, the productio...
Embodiment 1
[0031] The preparation method of sodium selenite vitamin C injection, the formula is:
[0032] For every prepared 20L of sodium selenite vitamin C injection, the addition of disodium edetate is 2g, the addition of sodium pyrosulfite is 38g, the addition of selenous acid is 19g, the addition of vitamin C is 160g, the addition of carbonic acid The addition amount of sodium hydrogen is 2.49Kg; Comprise the following steps:
[0033] (1) Add disodium edetate, sodium metabisulfite and selenous acid in sequence to water for injection saturated with carbon dioxide, add vitamin C after completely dissolving at 60°C, stir at 30°C to completely dissolve vitamin C, and then add carbonic acid Sodium bicarbonate was finally added to water for injection to make up the volume, and the pH was adjusted to 6.4 with citric acid or sodium bicarbonate to obtain a mixed solution;
[0034] (2) Add medicinal activated carbon to the mixed solution described in step (1), add 0.2g medicinal activated ca...
Embodiment 2
[0036] The preparation method of sodium selenite vitamin C injection, the formula is:
[0037] For every prepared 20L of sodium selenite vitamin C injection, the addition of disodium edetate is 10g, the addition of sodium metabisulfite is 40g, the addition of selenous acid is 21g, the addition of vitamin C is 600g, the addition of carbonic acid The addition amount of sodium hydrogen is 2.51Kg; Comprise the following steps:
[0038] (1) Add disodium edetate, sodium metabisulfite and selenous acid in sequence to water for injection saturated with carbon dioxide, add vitamin C after completely dissolving at 80°C, stir at 50°C to completely dissolve vitamin C, and then add carbonic acid Sodium bicarbonate was finally added to water for injection to make up the volume, and the pH was adjusted to 6.8 with citric acid or sodium bicarbonate to obtain a mixed solution;
[0039] (2) Add medicinal activated carbon to the mixed solution described in step (1), add 0.8g medicinal activated...
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