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Sodium selenite vitamin C injection and preparation method thereof

A technology for sodium selenite and vitamins, which is applied in pharmaceutical formulations, sulfur/selenium/tellurium active ingredients, and non-active ingredients medical preparations, etc. big problem

Inactive Publication Date: 2019-03-26
江西润泽药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the rapid development of social economy and the advancement of science and technology, whether domestic or wild animals are sick, they can play a good role in the treatment and recovery under the treatment of veterinary drugs. During the growth process of animals, they need to supplement selenium and vitamin C. It is used to prevent infertility caused by vitamin C and selenium deficiency, white muscle disease of young animals, and exudative quality of chicks. In the actual use process, it is inconvenient for livestock to supplement selenium and vitamin C respectively. The existing The production process of sodium selenite vitamin C medicine is relatively complicated and difficult to produce, so a new solution is needed to solve the problem.

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0014] The invention provides a kind of preparation method of sodium selenite vitamin C injection, comprises the following steps:

[0015] (1) First add edetate disodium, sodium metabisulfite and selenous acid to the water for injection saturated with carbon dioxide, and then add vitamin C after completely dissolving, stir to completely dissolve vitamin C, then add sodium bicarbonate and finally add water for injection Constant volume, obtain mixed solution;

[0016] (2) Add medicinal activated carbon to the mixed solution described in step (1), filter and decarburize after stirring, and fine filter the filtered filtrate with an ultrafiltration membrane; then continue to feed carbon dioxide gas into the filtrate after fine filtration , sterilized after potting under the condition of passing carbon dioxide to obtain an injection solution.

[0017] In the above technical solution, the production process of the preparation method of the present invention is simple, the productio...

Embodiment 1

[0031] The preparation method of sodium selenite vitamin C injection, the formula is:

[0032] For every prepared 20L of sodium selenite vitamin C injection, the addition of disodium edetate is 2g, the addition of sodium pyrosulfite is 38g, the addition of selenous acid is 19g, the addition of vitamin C is 160g, the addition of carbonic acid The addition amount of sodium hydrogen is 2.49Kg; Comprise the following steps:

[0033] (1) Add disodium edetate, sodium metabisulfite and selenous acid in sequence to water for injection saturated with carbon dioxide, add vitamin C after completely dissolving at 60°C, stir at 30°C to completely dissolve vitamin C, and then add carbonic acid Sodium bicarbonate was finally added to water for injection to make up the volume, and the pH was adjusted to 6.4 with citric acid or sodium bicarbonate to obtain a mixed solution;

[0034] (2) Add medicinal activated carbon to the mixed solution described in step (1), add 0.2g medicinal activated ca...

Embodiment 2

[0036] The preparation method of sodium selenite vitamin C injection, the formula is:

[0037] For every prepared 20L of sodium selenite vitamin C injection, the addition of disodium edetate is 10g, the addition of sodium metabisulfite is 40g, the addition of selenous acid is 21g, the addition of vitamin C is 600g, the addition of carbonic acid The addition amount of sodium hydrogen is 2.51Kg; Comprise the following steps:

[0038] (1) Add disodium edetate, sodium metabisulfite and selenous acid in sequence to water for injection saturated with carbon dioxide, add vitamin C after completely dissolving at 80°C, stir at 50°C to completely dissolve vitamin C, and then add carbonic acid Sodium bicarbonate was finally added to water for injection to make up the volume, and the pH was adjusted to 6.8 with citric acid or sodium bicarbonate to obtain a mixed solution;

[0039] (2) Add medicinal activated carbon to the mixed solution described in step (1), add 0.8g medicinal activated...

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Abstract

The invention discloses a sodium selenite vitamin C injection and a preparation method thereof. The preparation method comprises the steps that edetate disodium, sodium metabisulfite and seleninic acid are sequentially added into injection water saturated by carbon dioxide, vitamin C is added after the materials are completely dissolved, stirring is conducted so that the vitamin C is completely dissolved, then sodium bicarbonate is added, and the injection water is added finally to get constant volume, so that a mixed solution is obtained; medicinal active carbon is added into the mixed solution, the mixed solution is stirred and filtered to be decarburized, and a filtered filtrate is subjected to refined filtration by using an ultrafiltration membrane; and carbon dioxide gas is continuously guided into the filtrate which is subjected to refined filtration, and a product is potted, sealed and sterilized under existence of carbon dioxide, so that the injection is obtained. The production technology of the preparation method is simple and easy to control; the production efficiency is high by adopting the preparation method, effective components in the injection are stable, and the injection is very suitable for supplementing selenium and vitamin C to domestic animals, and has high popularization and application value.

Description

technical field [0001] The invention relates to sodium selenite vitamin C injection, in particular to a sodium selenite vitamin C injection and a preparation method thereof. Background technique [0002] Vitamin C, also known as ascorbic acid, is an acidic polyhydroxy compound containing 6 carbon atoms with the molecular formula C 6 h 8 o 6 , The molecular weight is 176.1. There are two types of naturally occurring ascorbic acid, L-type and D-type, the latter of which has no biological activity. Vitamin C is a colorless and odorless flaky crystal, easily soluble in water and insoluble in fat solvents. Stable in an acidic environment, it can promote its oxidative destruction when it encounters oxygen, heat, light, and alkaline substances in the air, especially in the presence of oxidase and trace copper, iron and other metal ions. [0003] With the rapid development of social economy and the advancement of science and technology, whether domestic or wild animals are sick...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K9/08A61K47/18A61P3/02A61K31/375
CPCA61K9/0019A61K9/08A61K31/375A61K33/04A61K47/183A61P3/02A61K2300/00
Inventor 廖年生眭荣春胡庭国
Owner 江西润泽药业有限公司
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