Preparation technology of Hongjin Xiaojie Tablet

Abstract

The invention provides a preparation process of Hongjin Xiaojie Tablets, which belongs to the technical field of pharmacy. Aiming at the various problems existing in the concentration method, drying method of concentrated thick cream, auxiliary materials and identification in the prior art, the preparation method of Hongjin Xiaojie Tablets is provided. The preparation process has been further improved, including directly concentrating the extract, drying the thick paste separately, increasing the amount of low-substituted hydroxypropyl cellulose, povidone K30 and magnesium stearate as excipients, and changing the drug identification and content determination items. , thereby achieving the purpose of shortening the production cycle, reducing energy consumption, reducing pollution risks and improving product quality.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation process of Hongjin Xiaojie Tablet. Background technique [0002] Hongjin Xiaojie Tablet is a new type of medicine refined from Hongjin Xiaojie Capsules based on modern scientific methods according to the different needs of patients. Spiced Sagevine, Chicken Yateng, Golden Buckwheat, Dahongpao and Bupleurum can soothe the liver and regulate qi, soften hard masses, activate blood circulation and remove blood stasis, reduce swelling and relieve pain, and are mostly used for breast lobular hyperplasia, uterine fibroids and ovarian cancer caused by qi stagnation and blood stasis. cyst. [0003] The preparation and quality control of Hongjin Xiaojie Tablets[J]. Xie Hai, Wang Shujun, Zhang Ying, et al. Chinese Modern Chinese Medicine, 2008,10(4):32-34. Disclosed the preparation method of Hongjin Xiaojie Tablets , including: take the prescription amount of Panax notogins...

AI Technical Summary

Problems solved by technology

[0004] Although the paper provides the preparation method and quality control method of Hongjin Xiaojie Tablets, some steps in the above-mentioned preparation process still need to be improved. For example, the use of combined concentration in the concentration step has the following disadvantages: (1) It takes three times to extract the filtrate. Concentrate after merging. After the three filtrates are combined, the amount is large, which is not conducive to continuous production; (2) After the three extractions are completed, the filtrates are combined and concentrated, and the filtrate storage time is longer, which increases the risk of microbial growth; (3) After the three extractions are completed, The filtrate is combined and concentrated again, and the whole extraction and concentration production cycle is long; (4) During the combination of the liquid medicine, the temperature drops, and when it is concentrated, it is heated again to increase energy consumption

Furthermore, the drying method of the concentrated thick paste in the above-mentioned production process is "mix the thick paste with the remaining five-flavored medicinal powders, dry, and pulverize". Mixing, due to the large amount of paste, it is difficult to mix and stir, which is not conducive to large-scale production; (2) The step of mixing thick paste with other five-flavored medicinal powders increases the risk of pollution; (3) After mixing thick paste and other five-flavored medicinal powders, it increases drying The production pressure of the process is not conducive to mass production and continuous production

Finally, the auxiliary materials in the above process are only the filler dextrin to adjust the tablet weight, and the lubricant magnesium stearate, which have the following disadvantages in large-scale production: (1) when granulating, the particles are loose and there are many powders; (2) tableting Low hardness and easy to break; (3) powder falling and fragments during the coating process, which makes the coating yield relatively low

Although this method can identify Bupleurum bupleuri, after unfolding, the R of the main board point f The value is large, which is not conducive to observation. At the same time, the spot color is not clear enough after the original color developer is developed.

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